Journal
ACS OMEGA
Volume 7, Issue 48, Pages 44180-44186Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.2c05353
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Funding
- Fundacao para a Ciencia e Tecnologia (FCT), Portugal [UIDB/04567/2020, UIDP/04567/2020, UIDB/04138/2020, UIDP/04138/2020, UIDB/00100/2020, UIDP/00100/2020, PTDC/QUI-OUT/28401/2017 (LISBOA-01-0145-FEDER-028401)]
- ALIESCOFAC, PhD program in Health Sciences from Universidad de Alcala and Universidade Lusofona de Human-idades e Tecnologias [UID/DTP/04567/2016, PADDIC 2016, PADDIC 2017]
- FCT [2021.03239.CEECIND]
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A pharmaceutical formulation consisting of a DHR-squalene conjugate was synthesized and analyzed using different techniques. The easy production of DHR-squalene conjugate nanoparticles in phosphate buffer suggests that this nanodelivery platform could effectively improve the solubility and bioavailability of DHR, achieving therapeutical systemic levels.
6,7-Dehydroroyleanone (DHR) is a caspase-induced cytotoxic abietane diterpene, frequently found on Plectranthus spp. A pharmaceutical formulation consisting of a DHR-squalene conjugate was synthesized and analyzed by different techniques such as scanning electron microscopy (SEM). The facile production of the dispersion of DHR-squalene conjugate nanoparticles in phosphate buffer (pH 7.4) suggests that this nanodelivery platform may be an effective system to improve the solubility and bioavailability of DHR, so that therapeutical systemic levels may be achieved.
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