Journal
ACS OMEGA
Volume 8, Issue 2, Pages 2406-2420Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.2c06822
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This study presents a one-pot solvothermal synthetic pathway for the preparation of uniformly dispersed ZrO2/rGO nanocrystals using the aqueous leaf extract of Andrographis paniculata. The synthesized nanocrystals exhibited dose-dependent cytotoxicity on human cancer cell lines (A549 and HCT116) and had the ability to induce apoptosis. The green synthesis of ZrO2/rGO nanocrystals shows potential in developing efficient therapeutic agents for cancer therapy.
This study mainly deals with an effective one-pot solvothermal synthetic pathway for the preparation of uniformly dispersed zirconium oxide nanoparticles on the flattened rough surface of reduced graphene oxide (ZrO2/rGO NCs) using the aqueous leaf extract of Andrographis paniculata. After obtaining detailed information on the preparation and characterization, the anticancer activity of the synthesized ZrO2/rGO nanocrystals (NCs) was evaluated on two human cancer cell lines (A549 and HCT116) along with one normal human cell line (hMSC). The 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide assays revealed that ZrO2/rGO NCs exhibited a dose-dependent cytotoxicity pattern. The cell viability (%) drastically decreases up to 96- 98% after exposure to an optimal concentration of 10 ppm nanocomposites. Analysis of both the reactive oxygen species generation and the Annexin V-FTIC staining assays reveal that ZrO2/rGO NCs have the ability to induce apoptosis in A549 and HCT116 cell lines. Thus, the green synthesis of ZrO2/rGO NCs shows potential in developing efficient therapeutic agents for cancer therapy.
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