Potential Regulation of miRNA-29 and miRNA-9 by Estrogens in Neurodegenerative Disorders: An Insightful Perspective

Finding a link between a hormone and microRNAs (miRNAs) is of great importance since it enables the adjustment of genetic composition or cellular functions without needing gene-level interventions. The dicer-mediated cleavage of precursor miRNAs is an interface link between miRNA and its regulators; any disruption in this process can affect neurogenesis. Besides, the hormonal regulation of miRNAs can occur at the molecular and cellular levels, both directly, through binding to the promoter elements of miRNAs, and indirectly, via regulation of the signaling effects of the post-transcriptional processing proteins. Estrogenic hormones have many roles in regulating miRNAs in the brain. This review discusses miRNAs, their detailed biogenesis, activities, and both the general and estrogen-dependent regulations. Additionally, we highlight the relationship between miR-29, miR-9, and estrogens in the nervous system. Such a relationship could be a possible etiological route for developing various neurodegenerative disorders.

Automated summary

Finding a link between hormones and microRNAs (miRNAs) is valuable for adjusting genetic composition or cellular functions without gene-level interventions. The cleavage of precursor miRNAs by dicer is an interface link between miRNA and its regulators, disruption of which can affect neurogenesis. Hormonal regulation of miRNAs occurs directly through binding to miRNA promoter elements and indirectly through regulation of post-transcriptional processing proteins' signaling effects. Estrogenic hormones play a significant role in regulating miRNAs in the brain, and their relationship with miR-29, miR-9 could be an etiological route for various neurodegenerative disorders.