Journal
ADVANCED MATERIALS
Volume 27, Issue 25, Pages 3737-3747Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201500900
Keywords
biomimetics; cell adhesion and migration; integrins; micropatterns; orthogonal functionalization
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Funding
- Bund der Freunde der TU Munchen e.V.
- IGSSE (International Graduate School of Science and Engineering)
- CompInt (Materials Science of Complex Interfaces) of the Elite Network of Bavaria
- IAS (Institute for Advanced Study) of Technische Universitat Munchen
- CIPSM (Center for Integrated Protein Science Munich)
- Deutsche Forschungsgemeinschaft (DFG) [PO 1727/1-1, OL 239/6-1, SP 520/13-1]
- Max Planck Society
- Research Foundation Flanders (FWO)
- BMBF/MPG network MaxSynBio
- European Union [PIEF-GA-2012-329908]
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Orthogonally functionalized binary micropatterned substrates are produced using a novel protocol. The use of adequate peptido-mimetics enables an unprecedented segregation of purified alpha v beta 3 and alpha 5 beta 1 integrins in adjacent microislands and evidences the preference of U2OS cells to colocalize such receptors. Moreover, this tendency can be altered by varying the geometry and composition of the micropatterns.
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