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Alternatives Therapeutic Approaches to Conventional Antibiotics: Advantages, Limitations and Potential Application in Medicine

ANTIBIOTICS-BASEL (2022)

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Review Environmental Sciences

Bacteriophage Therapy for Critical and High-Priority Antibiotic-Resistant Bacteria and Phage Cocktail-Antibiotic Formulation Perspective

Gursneh Kaur et al.

Summary: Phage therapy is addressing antibiotic resistance issues by not only killing target microbial populations directly, but also potentially leading to modifications in bacterial cell structures that could make them more sensitive to antibiotics. Application of phage therapy in antibiotic-resistant foodborne bacteria and modulation in gut microbes has been explored, along with discussions on phage cocktail antibiotic formulations containing multiple phages and antibiotics.

FOOD AND ENVIRONMENTAL VIROLOGY (2021)

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Article Virology

A Case of In Situ Phage Therapy against Staphylococcus aureus in a Bone Allograft Polymicrobial Biofilm Infection: Outcomes and Phage-Antibiotic Interactions

Brieuc Van Nieuwenhuyse et al.

Summary: Phage therapy shows potential in managing biofilm infections, but may have limitations in polymicrobial infections. Combination of surgery and antibiotic therapy has a positive impact on improving these infections, but does not completely prevent recurrence.

VIRUSES-BASEL (2021)

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Article Virology

Bacteriophage Rescue Therapy of a Vancomycin-Resistant Enterococcus faecium Infection in a One-Year-Old Child following a Third Liver Transplantation

Kevin Paul et al.

Summary: Phage therapy was successfully used to treat vancomycin-resistant Enterococcus faecium infection in a critically ill one-year-old girl, demonstrating its potential as an effective treatment option in multidrug-resistant bacterial infections.

VIRUSES-BASEL (2021)

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Review Immunology

Antimicrobial Peptides: A New Hope in Biomedical and Pharmaceutical Fields

Antonio Moretta et al.

Summary: Antibiotic resistance is a serious challenge, driving the search for new alternative molecules like AMPs as potential next-generation antibiotics. AMPs, as bioactive small proteins naturally produced by all living organisms, have aroused great interest for their ability to serve as the first line of defense against fungi, viruses, and bacteria.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Review Microbiology

Nanostructured Antimicrobial Peptides: Crucial Steps of Overcoming the Bottleneck for Clinics

Zhanyi Yang et al.

Summary: Antimicrobial peptides (AMPs) are considered a viable alternative to antibiotics due to their broad-spectrum antimicrobial activity and ease of synthesis, but they have disadvantages such as low bioavailability, poor protease resistance, and high cytotoxicity. Nanostructured antimicrobial peptides (Ns-AMPs) address these limitations through various nanosystem modifications, improving therapeutic efficacy and reducing side effects. This review highlights the advantages of Ns-AMPs in terms of biological stability and antimicrobial activity, as well as discussing their controlled release mechanisms and future research directions.

FRONTIERS IN MICROBIOLOGY (2021)

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Review Medicine, General & Internal

The Role of Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease

Magdalena Stojek et al.

Summary: The exact pathogenesis of inflammatory bowel disease is not fully understood, but it is believed to involve genetic predisposition, environmental triggers, and exaggerated immune responses. Current management strategies focus on correcting immune responses, with potential new treatments like FMT showing promising results.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Infectious Diseases

Potential for Phages in the Treatment of Bacterial Sexually Transmitted Infections

Kathryn Cater et al.

Summary: Bacterial sexually transmitted infections (BSTIs) are becoming increasingly concerning as antibiotic treatment options decrease. Phage therapy has been utilized in some countries for bacterial illnesses, but has not yet been used for BSTIs. The potential efficacy of phage therapy in treating BSTIs requires further research and exploration, as it presents a possible alternative to traditional antibiotic treatments.

ANTIBIOTICS-BASEL (2021)

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Review Infectious Diseases

Bacteriophage Technology and Modern Medicine

Aa Haeruman Azam et al.

Summary: Phages, as antibacterial agents, have a long history of use but were abandoned in most countries after the discovery of antibiotics. The rise of antimicrobial-resistant bacteria globally has renewed interest in phage therapy as an alternative to combatting AMR bacteria. Advances in molecular biology and genetic engineering have accelerated the development of phage-related products with superior therapeutic potentials against bacterial infections, and phage-based technology now serves multiple purposes beyond antibacterial treatment in modern medicine.

ANTIBIOTICS-BASEL (2021)

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Review Infectious Diseases

Gram-Positive Pneumonia: Possibilities Offered by Phage Therapy

Lucia Fernandez et al.

Summary: Pneumonia, whether viral or bacterial, presents challenges to healthcare systems and effective antimicrobial strategies. Antibiotic resistance in bacterial pneumonia is a main concern, and alternative therapeutics like phage therapy may offer a solution. Regulatory hurdles and research difficulties remain obstacles to the clinical use of phage therapy.

ANTIBIOTICS-BASEL (2021)

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Review Infectious Diseases

Ceftazidime-Avibactam for the Treatment of Serious Gram-Negative Infections with Limited Treatment Options: A Systematic Literature Review

Alex Soriano et al.

Summary: This systematic literature review evaluated the real-world use of ceftazidime-avibactam for infections caused by aerobic Gram-negative organisms in adults with limited treatment options. Results showed successful outcomes and infrequent resistance emergence, making it a valuable treatment option for such infections.

INFECTIOUS DISEASES AND THERAPY (2021)

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Review Biochemistry & Molecular Biology

A combination therapy of Phages and Antibiotics: Two is better than one

Xianghui Li et al.

Summary: The emergence of antibiotic resistance is a major challenge for global health, leading to an urgent need for alternative therapeutic strategies due to a shortage of antibiotic pipelines. Phage-antibiotic synergy (PAS) has emerged as a promising approach to combat antibiotic-resistant pathogens, by enhancing bacterial killing and reducing the development of antibiotic resistance through a combination of phages and antibiotics. Additionally, the genetic and molecular mechanisms of phage antibiotic synergy, as well as the potential of engineered phages in reducing bacterial pathogenicity, are addressed in this review.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Review Microbiology

Clostridioides difficile phage biology and application

Joshua Heuler et al.

Summary: Clostridioides difficile, formerly known as Clostridium difficile, is the causative agent of C. difficile infections, which pose challenges in healthcare settings. Antibiotic-induced dysbiosis allows C. difficile colonization in the gut. Phage infection offers potential new treatment strategies against C. difficile infections.

FEMS MICROBIOLOGY REVIEWS (2021)

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Article Microbiology

Ceftazidime-Avibactam To Treat Life-Threatening Infections by Carbapenem-Resistant Pathogens in Critically Ill Mechanically Ventilated Patients

Vasiliki Tsolaki et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

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Review Microbiology

Phage therapy efficacy: a review of the last 10 years of preclinical studies

Luis D. R. Melo et al.

CRITICAL REVIEWS IN MICROBIOLOGY (2020)

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Article Infectious Diseases

Antibiotic combination therapy against resistant bacterial infections: synergy, rejuvenation and resistance reduction

Anthony R. M. Coates et al.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2020)

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Article Infectious Diseases

Activity of ceftolozane-tazobactam against Gram-negative pathogens isolated from lower respiratory tract infections in the Asia-Pacific region: SMART 2015-2016

Shu-Chen Kuo et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)

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Review Biotechnology & Applied Microbiology

Therapeutic bacteriophages as a rescue treatment for drug-resistant infections - an in vivo studies overview

M. Kwiatek et al.

JOURNAL OF APPLIED MICROBIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Antimicrobial Susceptibility and Antibacterial Mechanism of Limonene against Listeria monocytogenes

Yingjie Han et al.

MOLECULES (2020)

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Review Biotechnology & Applied Microbiology

Antimicrobial host defence peptides: functions and clinical potential

Neeloffer Mookherjee et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

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Review Pharmacology & Pharmacy

Evaluation of Eravacycline: A Novel Fluorocycline

Sara Alosaimy et al.

PHARMACOTHERAPY (2020)

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Article Ethics

The Future of Phage: Ethical Challenges of Using Phage Therapy to Treat Bacterial Infections

Jonathan Anomaly

PUBLIC HEALTH ETHICS (2020)

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Editorial Material Infectious Diseases

COVID-19: don't neglect antimicrobial stewardship principles!

B. D. Huttner et al.

CLINICAL MICROBIOLOGY AND INFECTION (2020)

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Editorial Material Infectious Diseases

COVID-19 and the potential long-term impact on antimicrobial resistance

Timothy M. Rawson et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2020)

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Article Infectious Diseases

Application of phage therapy: Synergistic effect of phage EcSw (ΦEcSw) and antibiotic combination towards antibiotic-resistant Escherichia coli

Maheswaran Easwaran et al.

TRANSBOUNDARY AND EMERGING DISEASES (2020)

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Review Medical Laboratory Technology

New and alternative strategies for the prevention, control, and treatment of antibiotic-resistant Campylobacter

Lei Dai et al.

TRANSLATIONAL RESEARCH (2020)

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Editorial Material Medicine, General & Internal

How covid-19 is accelerating the threat of antimicrobial resistance

Jeremy Hsu

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Review Physics, Applied

Physics in nanomedicine: Phenomena governing the in vivo performance of nanoparticles

Lucas A. Lane

APPLIED PHYSICS REVIEWS (2020)

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Article Infectious Diseases

Ceftolozane-tazobactam and ceftazidime-avibactam activity against β-lactam-resistant Pseudomonas aeruginosa and extended-spectrum β-lactamase-producing Enterobacterales clinical isolates from US medical centres

Elizabeth B. Hirsch et al.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2020)

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Article Medicine, General & Internal

Multidrug-Resistant Bacterial Infections in US Hospitalized Patients, 2012-2017

John A. Jernigan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Biotechnology & Applied Microbiology

Antimicrobial peptides as therapeutic agents: opportunities and challenges

Margit Mahlapuu et al.

CRITICAL REVIEWS IN BIOTECHNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Phage S144, a New Polyvalent Phage InfectingSalmonellaspp. andCronobacter sakazakii

Michela Gambino et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Agriculture, Dairy & Animal Science

Ruminal acidosis, bacterial changes, and lipopolysaccharides

Hugo F. Monteiro et al.

JOURNAL OF ANIMAL SCIENCE (2020)

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Review Biochemistry & Molecular Biology

Immunomodulatory Activities of Selected Essential Oils

Georg Sandner et al.

BIOMOLECULES (2020)

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Review Infectious Diseases

Phages for Biofilm Removal

Celia Ferriol-Gonzalez et al.

ANTIBIOTICS-BASEL (2020)

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Review Microbiology

Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields

Yuchen Huan et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Review Immunology

Impact ofN-Acyl-Homoserine Lactones, Quorum Sensing Molecules, on Gut Immunity

Garance Coquant et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Virology

Characterization of Salmonella Isolates from Various Geographical Regions of the Caucasus and Their Susceptibility to Bacteriophages

Khatuna Makalatia et al.

VIRUSES-BASEL (2020)

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Article Infectious Diseases

Phage Therapy: Towards a Successful Clinical Trial

Andrzej Gorski et al.

ANTIBIOTICS-BASEL (2020)

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Article Medicine, Research & Experimental

Antimicrobial peptides - Advances in development of therapeutic applications

Huy Xuan Luong et al.

LIFE SCIENCES (2020)

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Review Microbiology

New beta-Lactam-beta-Lactamase Inhibitor Combinations

Dafna Yahav et al.

CLINICAL MICROBIOLOGY REVIEWS (2020)

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Review Biochemistry & Molecular Biology

Peptide based antimicrobials: Design strategies and therapeutic potential

Prakash Kishore Hazam et al.

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2019)

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Article Immunology

Biotechnological applications of quorum sensing inhibition as novel therapeutic strategies for multidrug resistant pathogens

Mona Shaaban et al.

MICROBIAL PATHOGENESIS (2019)

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Review Microbiology

Drug combinations: a strategy to extend the life of antibiotics in the 21 st century

Mike Tyers et al.

NATURE REVIEWS MICROBIOLOGY (2019)

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Letter Medicine, General & Internal

Plazomicin for Infections Caused by Carbapenem-Resistant Enterobacteriaceae

James A. McKinnell et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Article Nutrition & Dietetics

PHAGE Study: Effects of Supplemental Bacteriophage Intake on Inflammation and Gut Microbiota in Healthy Adults

Hallie P. Febvre et al.

NUTRIENTS (2019)

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Article Microbiology

Characterizing the Biology of Lytic Bacteriophage vB_EaeM_φEap-3 Infecting Multidrug-Resistant Enterobacter aerogenes

Jiangtao Zhao et al.

FRONTIERS IN MICROBIOLOGY (2019)

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Review Chemistry, Multidisciplinary

Reassessing the Host Defense Peptide Landscape

Evan F. Haney et al.

FRONTIERS IN CHEMISTRY (2019)

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Review Pharmacology & Pharmacy

Eravacycline: The Tetracyclines Strike Back

Maria Heaney et al.

ANNALS OF PHARMACOTHERAPY (2019)

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Review Virology

Current State of Compassionate Phage Therapy

Shawna McCallin et al.

VIRUSES-BASEL (2019)

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Review Pharmacology & Pharmacy

Advantages and Limitations of Bacteriophages for the Treatment of Bacterial Infections

Nicola Principi et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Multidisciplinary Sciences

Efficacy and potential of phage therapy against multidrug resistant Shigella spp.

Swee-Seong Tang et al.

PEERJ (2019)

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Article Infectious Diseases

Lytic bacteriophages against multidrug-resistant Staphylococcus aureus, Enterococcus faecalis and Escherichia coli isolates from orthopaedic implant-associated infections

Joana Barros et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2019)

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Review Immunology

The Role of Fecal Microbiota Transplantation in Reducing Intestinal Colonization With Antibiotic-Resistant Organisms: The Current Landscape and Future Directions

Michael H. Woodworth et al.

OPEN FORUM INFECTIOUS DISEASES (2019)

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Article Microbiology

Eravacycline: a new treatment option for complicated intra-abdominal infections in the age of multidrug resistance

Joseph S. Solomkin et al.

FUTURE MICROBIOLOGY (2019)

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Review Biochemistry & Molecular Biology

Development and Clinical Trials of Nucleic Acid Medicines for Pancreatic Cancer Treatment

Keiko Yamakawa et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Nanoscience & Nanotechnology

Enhanced antibiotic activity of ampicillin conjugated to gold nanoparticles on PEGylated rosette nanotubes

Yiwen Fan et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Review Chemistry, Multidisciplinary

Nanoparticle-drug conjugates treating bacterial infections

Pavlina Jelinkova et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Chemistry, Multidisciplinary

Predictive Metabolomic Signatures for Safety Assessment of Metal Oxide Nanoparticles

Li Cui et al.

ACS NANO (2019)

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Article Immunology

Cefiderocol: Discovery, Chemistry, and In Vivo Profiles of a Novel Siderophore Cephalosporin

Takafumi Sato et al.

CLINICAL INFECTIOUS DISEASES (2019)

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Review Microbiology

Methicillin-Resistant Staphylococcus aureus in Hospitals: Latest Trends and Treatments Based on Bacteriophages

Andrea Alvarez et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2019)

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Article Microbiology

In Vitro Activity of Plazomicin against Gram-Negative and Gram-Positive Bacterial Pathogens Isolated from Patients in Canadian Hospitals from 2013 to 2017 as Part of the CANWARD Surveillance Study

Andrew Walkty et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2019)

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Review Pharmacology & Pharmacy

Nanoparticles in the Treatment of Infections Caused by Multidrug-Resistant Organisms

Nan-Yao Lee et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Infectious Diseases

Potential role of the antimicrobial peptide Tachyplesin III against multidrug-resistant P. aeruginosa and A. baumannii coinfection in an animal model

Jialong Qi et al.

INFECTION AND DRUG RESISTANCE (2019)

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Review Microbiology

Phage Therapy in the Postantibiotic Era

Fernando L. Gordillo Altamirano et al.

CLINICAL MICROBIOLOGY REVIEWS (2019)

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Review Microbiology

Bacteriophages: an overview of the control strategies against multiple bacterial infections in different fields

Muhsin Jamal et al.

JOURNAL OF BASIC MICROBIOLOGY (2019)

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Review Infectious Diseases

Biological challenges of phage therapy and proposed solutions: a literature review

Katherine M. Caflisch et al.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2019)

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Article Infectious Diseases

Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial

Patrick Jault et al.

LANCET INFECTIOUS DISEASES (2019)

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Review Biotechnology & Applied Microbiology

Cytotoxicity-Related Bioeffects Induced by Nanoparticles: The Role of Surface Chemistry

Hainan Sun et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)

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Article Infectious Diseases

Evaluation of Plazomicin, Tigecycline, and Meropenem Pharmacodynamic Exposure against Carbapenem-Resistant Enterobacteriaceae in Patients with Bloodstream Infection or Hospital-Acquired/Ventilator-Associated Pneumonia from the CARE Study (ACHN-490-007)

Joseph L. Kuti et al.

INFECTIOUS DISEASES AND THERAPY (2019)

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Article Infectious Diseases

Exacerbations of Chronic Rhinosinusitis-Microbiology and Perspectives of Phage Therapy

Joanna Szaleniec et al.

ANTIBIOTICS-BASEL (2019)

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Article Infectious Diseases

Directed Evolution of a Mycobacteriophage

Maria Cebria-Mendoza et al.

ANTIBIOTICS-BASEL (2019)

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Article Microbiology

In Vitro Activity of Plazomicin against Gram-Negative and Gram-Positive Isolates Collected from US Hospitals and Comparative Activities of Aminoglycosides against Carbapenem-Resistant Enterobacteriaceae and Isolates Carrying Carbapenemase Genes

Mariana Castanheira et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2018)

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Article Microbiology

Evaluation of the Bactericidal Activity of Plazomicin and Comparators against Multidrug-Resistant Enterobacteriaceae

M. Thwaites et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2018)

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Article Microbiology

Evaluation of the In Vitro Activity of Eravacycline against a Broad Spectrum of Recent Clinical Anaerobic Isolates

David R. Snydman et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2018)

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Article Microbiology

Pharmacokinetics, Tolerability, and Safety of Murepavadin, a Novel Antipseudomonal Antibiotic, in Subjects with Mild, Moderate, or Severe Renal Function Impairment

Glenn E. Dale et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2018)

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Article Infectious Diseases

In vitro activity of eravacycline against 2213 Gram-negative and 2424 Gram-positive bacterial pathogens isolated in Canadian hospital laboratories: CANWARD surveillance study 2014-2015

George G. Zhanel et al.

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2018)

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Article Infectious Diseases

Activity of plazomicin in combination with other antibiotics against multidrug-resistant Enterobacteriaceae

M. Thwaites et al.

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2018)

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Review Infectious Diseases

Ceftolozane/tazobactam: place in therapy

Daniele Roberto Giacobbe et al.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2018)

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Review Materials Science, Biomaterials

Do physico-chemical properties of silver nanoparticles decide their interaction with biological media and bactericidal action? A review

Vikram Pareek et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

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Article Immunology

Bovine mastitis: An appraisal of its alternative herbal cure

Saleem Mushtaq et al.

MICROBIAL PATHOGENESIS (2018)

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Review Biotechnology & Applied Microbiology

Antimicrobial peptides produced by Brevibacillus spp.: structure, classification and bioactivity: a mini review

Xu Yang et al.

WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY (2018)

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Article Microbiology

Phage Therapy as a Promising New Treatment for Lung Infection Caused by Carbapenem-Resistant Acinetobacter baumannii in Mice

Yunfen Hua et al.

FRONTIERS IN MICROBIOLOGY (2018)

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Article Chemistry, Medicinal

Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes

Georgina Cox et al.

ACS INFECTIOUS DISEASES (2018)

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Review Multidisciplinary Sciences

Bacterial antagonism in host-associated microbial communities

Leonor Garcia-Bayona et al.

SCIENCE (2018)

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Article Microbiology

Bacteriophage ZCKP1: A Potential Treatment for Klebsiella pneumoniae Isolated From Diabetic Foot Patients

Omar A. Taha et al.

FRONTIERS IN MICROBIOLOGY (2018)

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Article Infectious Diseases

Cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infections caused by Gram-negative uropathogens: a phase 2, randomised, double-blind, non-inferiority trial

Simon Portsmouth et al.

LANCET INFECTIOUS DISEASES (2018)

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Article Multidisciplinary Sciences

Complete genome analysis of a Siphoviridae phage TSK1 showing biofilm removal potential against Klebsiella pneumoniae

Rabia Tabassum et al.

SCIENTIFIC REPORTS (2018)

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Review Biotechnology & Applied Microbiology

Advances in therapeutic bacterial antisense biotechnology

John P. Hegarty et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2018)

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Article Infectious Diseases

In Vitro Synergism of Silver Nanoparticles with Antibiotics as an Alternative Treatment in Multiresistant Uropathogens

Montserrat Lopez-Carrizales et al.

ANTIBIOTICS-BASEL (2018)

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Article Pharmacology & Pharmacy

Physical compatibility of ceftolozane-tazobactam with selected i.v. drugs during simulated Y-site administration

Abrar K. Thabit et al.

AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY (2017)

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Review Microbiology

The therapeutic applications of antimicrobial peptides (AMPs): a patent review

Hee-Kyoung Kang et al.

JOURNAL OF MICROBIOLOGY (2017)

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Review Biochemistry & Molecular Biology

Antibacterial and Antifungal Activities of Spices

Qing Liu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Infectious Diseases

In vitro activity of plazomicin against β-lactamase-producing carbapenem-resistant Enterobacteriaceae (CRE)

Yunliang Zhang et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2017)

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Article Infectious Diseases

Activity of cefiderocol (S-649266) against carbapenem-resistant Gram-negative bacteria collected from inpatients in Greek hospitals

Matthew E. Falagas et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2017)

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Article Infectious Diseases

Antimicrobial susceptibility of clinical isolates of Neisseria gonorrhoeae to alternative antimicrobials with therapeutic potential

P. R. S. Lagace-Wiens et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2017)

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Article Infectious Diseases

Plazomicin activity against polymyxin-resistant Enterobacteriaceae, including MCR-1-producing isolates

Valerie Denervaud-Tendon et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2017)

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Review Biochemistry & Molecular Biology

Biological Activities of Essential Oils: From Plant Chemoecology to Traditional Healing Systems

Javad Sharifi-Rad et al.

MOLECULES (2017)

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Article Virology

Differential Effect of Newly Isolated Phages Belonging to PB1-Like, phiKZ-Like and LUZ24-Like Viruses against Multi-Drug Resistant Pseudomonas aeruginosa under Varying Growth Conditions

Simone Latz et al.

VIRUSES-BASEL (2017)

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Article Microbiology

Isolation and Characterization of phiLLS, a Novel Phage with Potential Biocontrol Agent against Multidrug-Resistant Escherichia coli

Luis Amarillas et al.

FRONTIERS IN MICROBIOLOGY (2017)

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Article Immunology

In Vitro Activity of Eravacycline and Comparator Antimicrobials Against 143 Strains of Bacteroides Species.

Diane Citron et al.

Open Forum Infectious Diseases (2017)

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Review Chemistry, Medicinal

Essential Oils and Antifungal Activity

Filomena Nazzaro et al.

PHARMACEUTICALS (2017)

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Article Biotechnology & Applied Microbiology

Phage Therapy against &ITStreptococcus pneumoniae&IT: Modern Tool to Control Pneumonia

Muhammad Imran Qadir et al.

CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION (2017)

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Article Microbiology

Multicenter Evaluation of Ceftazidime-Avibactam and Ceftolozane-Tazobactam Inhibitory Activity against Meropenem-Nonsusceptible Pseudomonas aeruginosa from Blood, Respiratory Tract, and Wounds

Mordechai Grupper et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2017)

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Review Pharmacology & Pharmacy

Safety of antisense oligonucleotide and siRNA-based therapeutics

Xuan Chi et al.

DRUG DISCOVERY TODAY (2017)

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Review Gastroenterology & Hepatology

Fecal microbiota transplantation: in perspective

Shaan Gupta et al.

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2016)

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Review Immunology

Ceftazidime/Avibactam and Ceftolozane/Tazobactam: Second-generation β-Lactam/β-Lactamase Inhibitor Combinations

David van Duin et al.

CLINICAL INFECTIOUS DISEASES (2016)

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Review Microbiology

Antisense antimicrobial therapeutics

Erin K. Sully et al.

CURRENT OPINION IN MICROBIOLOGY (2016)

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Review Pharmacology & Pharmacy

Review of Eravacycline, a Novel Fluorocycline Antibacterial Agent

George G. Zhanel et al.

DRUGS (2016)

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Article Agricultural Engineering

Chemical composition, antioxidant, antibacterial and anti-quorum sensing activities of Eucalyptus globulus and Eucalyptus radiata essential oils

Angelo Luis et al.

INDUSTRIAL CROPS AND PRODUCTS (2016)

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Article Immunology

Aminoglycoside Resistance The Emergence of Acquired 16S Ribosomal RNA Methyltransferases

Yohei Doi et al.

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (2016)

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Review Biochemistry & Molecular Biology

Marine Antimicrobial Peptides: Nature Provides Templates for the Design of Novel Compounds against Pathogenic Bacteria

Annarita Falanga et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Review Chemistry, Multidisciplinary

Current applications of nanoparticles in infectious diseases

Hinojal Zazo et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Review Public, Environmental & Occupational Health

Adverse events in faecal microbiota transplant: a review of the literature

M. Baxter et al.

JOURNAL OF HOSPITAL INFECTION (2016)

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Review Biochemistry & Molecular Biology

Evolutionary Rationale for Phases as Complements of Antibiotics

Clara Torres-Barcelo et al.

TRENDS IN MICROBIOLOGY (2016)

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Review Biochemistry & Molecular Biology

Mechanisms of resistance to aminoglycoside antibiotics: overview and perspectives

Sylvie Garneau-Tsodikova et al.

MEDCHEMCOMM (2016)

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Article Multidisciplinary Sciences

In Silico Evaluation of the Impacts of Quorum Sensing Inhibition (QSI) on Strain Competition and Development of QSI Resistance

Guopeng Wei et al.

SCIENTIFIC REPORTS (2016)

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Article Pharmacology & Pharmacy

Bacteriophages as Therapeutic and Prophylactic Means: Summary of the Soviet and Post Soviet Experiences

Nina Chanishvili

CURRENT DRUG DELIVERY (2016)

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Review Infectious Diseases

Fecal microbiota transplantation for the intestinal decolonization of extensively antimicrobial-resistant opportunistic pathogens: a review

Amee R. Manges et al.

INFECTIOUS DISEASES (2016)

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Article Multidisciplinary Sciences

Lipid-II Independent Antimicrobial Mechanism of Nisin Depends On Its Crowding And Degree Of Oligomerization

Ashutosh Prince et al.

SCIENTIFIC REPORTS (2016)

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Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives

Hyun Ho Choi et al.

CLINICAL ENDOSCOPY (2016)

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Clostridium difficile Infection and Fecal Microbiota Transplant

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AACN ADVANCED CRITICAL CARE (2016)

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News Item Pharmacology & Pharmacy

Ceftazidime with β-lactamase inhibitor approved for complicated infections

Cheryl A. Thompson

AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY (2015)

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Article Biochemistry & Molecular Biology

Airway Epithelial Cell Integrity Protects from Cytotoxicity of Pseudomonas aeruginosa Quorum-Sensing Signals

Davide Losa et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2015)

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Article Microbiology

Can Plazomicin Alone or in Combination Be a Therapeutic Option against Carbapenem-Resistant Acinetobacter baumannii?

Cristina Garcia-Salguero et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)

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Article Infectious Diseases

Fecal microbiota transplantation restores dysbiosis in patients with methicillin resistant Staphylococcus aureus enterocolitis

Yao Wei et al.

BMC INFECTIOUS DISEASES (2015)

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Characterization of new Myoviridae bacteriophage WZ1 against multi-drug resistant (MDR) Shigella dysenteriae

Muhsin Jamal et al.

JOURNAL OF BASIC MICROBIOLOGY (2015)

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Article Medicine, Research & Experimental

Toward Repositioning Niclosamide for Antivirulence Therapy of Pseudomonas aeruginosa Lung Infections: Development of Inhalable Formulations through Nanosuspension Technology

Gabriella Costabile et al.

MOLECULAR PHARMACEUTICS (2015)

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Review Biochemistry & Molecular Biology

Antibacterial Activity of Essential Oils and Their Isolated Constituents against Cariogenic Bacteria: A Systematic Review

Irlan Almeida Freires et al.

MOLECULES (2015)

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Article Biology

Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment

Sibhghatulla Shaikh et al.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2015)

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Article Immunology

Loss of Vancomycin-Resistant Enterococcus Fecal Dominance in an Organ Transplant Patient With Clostridium difficile Colitis After Fecal Microbiota Transplant

Joshua Stripling et al.

OPEN FORUM INFECTIOUS DISEASES (2015)

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Quorum sensing enhancement of the stress response promotes resistance to quorum quenching and prevents social cheating

Rodolfo Garcia-Contreras et al.

ISME JOURNAL (2015)

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Ecology of Anti-Biofilm Agents I: Antibiotics versus Bacteriophages

Stephen T. Abedon

PHARMACEUTICALS (2015)

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Gramicidin A: A New Mission for an Old Antibiotic

Justin M. David et al.

JOURNAL OF KIDNEY CANCER AND VHL (2015)

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Carbapenem-Resistant Klebsiella pneumoniae Strains Exhibit Diversity in Aminoglycoside-Modifying Enzymes, Which Exert Differing Effects on Plazomicin and Other Agents

Reem Almaghrabi et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)

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Plant antimicrobial peptides

Robert Nawrot et al.

FOLIA MICROBIOLOGICA (2014)

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Review Immunology

A historical overview of bacteriophage therapy as an alternative to antibiotics for the treatment of bacterial pathogens

Xavier Wittebole et al.

VIRULENCE (2014)

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Article Medicine, General & Internal

The safety and efficacy of daptomycin versus other antibiotics for skin and soft-tissue infections: a meta-analysis of randomised controlled trials

Shou Zhen Wang et al.

BMJ OPEN (2014)

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Article Gastroenterology & Hepatology

The abundance of antibiotic resistance genes in human guts has correlation to the consumption of antibiotics in animal

Yongfei Hu et al.

GUT MICROBES (2014)

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Nanotechnology as a therapeutic tool to combat microbial resistance

Robert Y. Pelgrift et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

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New Life for an Old Drug: the Anthelmintic Drug Niclosamide Inhibits Pseudomonas aeruginosa Quorum Sensing

Francesco Imperi et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)

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Antibacterial Activity of Eravacycline (TP-434), a Novel Fluorocycline, against Hospital and Community Pathogens

J. A. Sutcliffe et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)

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Antimicrobial Resistance and Virulence: a Successful or Deleterious Association in the Bacterial World?

Alejandro Beceiro et al.

CLINICAL MICROBIOLOGY REVIEWS (2013)

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Current and Potential Use of Citrus Essential Oils

Eristanna Palazzolo et al.

CURRENT ORGANIC CHEMISTRY (2013)

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Phage cocktails and the future of phage therapy

Benjamin K. Chan et al.

FUTURE MICROBIOLOGY (2013)

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Butyrate-producing Clostridium cluster XIVa species specifically colonize mucins in an in vitro gut model

Pieter Van den Abbeele et al.

ISME JOURNAL (2013)

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The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria

Elizabeth M. H. Wellington et al.

LANCET INFECTIOUS DISEASES (2013)

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Combined effect of a peptide-morpholino oligonucleotide conjugate and a cell-penetrating peptide as an antibiotic

Donna Wesolowski et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Amino acid composition of proteins reduces deleterious impact of mutations

Sahand Hormoz

SCIENTIFIC REPORTS (2013)

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Infections caused by resistant Gram-negative bacilli: New molecules and combinations

V. Cattoir

JOURNAL DES ANTI-INFECTIEUX (2013)

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The intestinal microbiota is the future of bacterial multidrug-resistance

E. Ruppe et al.

JOURNAL DES ANTI-INFECTIEUX (2013)

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Ceftolozane/tazobactam: a novel antipseudomonal cephalosporin and β-lactamase-inhibitor combination

Mark Bounthavong et al.

Infection and Drug Resistance (2013)

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Letter Gastroenterology & Hepatology

Should We Standardize the 1,700-Year-Old Fecal Microbiota Transplantation?

Faming Zhang et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2012)

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Fluorocyclines. 1. 7-Fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline: A Potent, Broad Spectrum Antibacterial Agent

Xiao-Yi Xiao et al.

JOURNAL OF MEDICINAL CHEMISTRY (2012)

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Synthesis and antibacterial activity of silver nanoparticles against gram-positive and gram-negative bacteria

Maribel Guzman et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2012)

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Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective

Anders Folkesson et al.

NATURE REVIEWS MICROBIOLOGY (2012)

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Pathogenesis and Pathophysiology of Pneumococcal Meningitis

Barry B. Mook-Kanamori et al.

CLINICAL MICROBIOLOGY REVIEWS (2011)

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Essential oils in poultry nutrition: Main effects and modes of action

A. Brenes et al.

ANIMAL FEED SCIENCE AND TECHNOLOGY (2010)

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Chemical Composition and in Vitro Antimicrobial and Mutagenic Activities of Seven Lamiaceae Essential Oils

Laura De Martino et al.

MOLECULES (2009)

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Biosynthesis, immunity, regulation, mode of action and engineering of the model lantibiotic nisin

J. Lubelski et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2008)

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Phage as an antimicrobial agent: d'Herelle's heretical theories and their role in the decline of phage prophylaxis in the West

Dottore Emiliano Fruciano et al.

CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY (2007)

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A review of antimicrobial peptides and their therapeutic potential as anti-infective drugs

YJ Gordon et al.

CURRENT EYE RESEARCH (2005)

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Insect antimicrobial peptides: Structures, properties and gene regulation

P Bulet et al.

PROTEIN AND PEPTIDE LETTERS (2005)

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Gene organization and sequences of pediocin AcH/PA-1 production operons in Pediococcus and Lactobacillus plasmids

KW Miller et al.

LETTERS IN APPLIED MICROBIOLOGY (2005)

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Anti-Listeria monocytogenes activity of essential oils components of conifers

A Mourey et al.

FOOD CONTROL (2002)

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Antimicrobial activity of individual and mixed fractions of dill, cilantro, coriander and eucalyptus essential oils

PJ Delaquis et al.

INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY (2002)

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Lactation mastitis: Occurrence and medical management among 946 breastfeeding women in the United States

B Foxman et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2002)

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Bactericidal antisense effects of peptide-PNA conjugates

L Good et al.

NATURE BIOTECHNOLOGY (2001)

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Quorum sensing in bacteria

MB Miller et al.

ANNUAL REVIEW OF MICROBIOLOGY (2001)

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