Journal
ANTIBIOTICS-BASEL
Volume 11, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/antibiotics11121780
Keywords
biphasic calcium phosphate; Ag nanoparticles; antibacterial activity; hydroxyapatite; beta-tricalcium phosphate; MTT assay
Categories
Funding
- Council of Scientific and Industrial Research (CSIR), Government of India
- [09/115(0793)/2020 EMR-I]
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This study evaluated the application of silver nanoparticles combined with biphasic calcium phosphate (BCP) composites in the field of orthopedics. The results showed that the composites had good osteoconductivity and biocompatibility, and exhibited antibacterial activity against various microorganisms.
Biphasic calcium phosphate (BCP) serves as one of the substitutes for bone as it consists of an intimate mixture of beta-tricalcium phosphate (beta-TCP) and hydroxyapatite (HAP) in different ratios. BCP, because of its inbuilt properties such as osteoconductivity, biocompatibility, and biostability in several clinical models serves as a bone substituent for orthopedic applications. Therefore, the present study aimed to assess the effectiveness of silver (Ag) nanoparticles (NPs) combined with BCP composites for the orthopedic sector of bone tissue regeneration and growth. In this regard, we first synthesized Ag-BCP microclusters by the double-emulsion method and then characterized the composite for various physicochemical properties, including the crystallinity and crystal structure, bonding and functionality, porosity, morphology, surface charges, topography, and thermal stability. In addition, the antibacterial activity of Ag-BCP was tested against gram-positive and gram-negative microorganisms such as Staphylococcus aureus, Candida albicans, and Escherichia coli. Finally, the cytocompatibility of Ag-BCP was confirmed against the fibroblast cells in vitro.
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