Journal
CELL METABOLISM
Volume 21, Issue 2, Pages 237-248Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2014.12.021
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Funding
- NIH [HL-077439, HL-111665, HL-093039, DK-099653, U01-HL-100401]
- Foundation Leducq Networks of Excellence
- Cancer Prevention & Research Institute of Texas
- Robert A. Welch Foundation [1-0025]
- American Heart Association [14POST18320034]
- NIH T32 grant
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Skeletal and cardiac muscles play key roles in the regulation of systemic energy homeostasis and display remarkable plasticity in their metabolic responses to caloric availability and physical activity. In this Perspective we discuss recent studies highlighting transcriptional mechanisms that govern systemic metabolism by striated muscles. We focus on the participation of the Mediator complex in this process, and suggest that tissue-specific regulation of Mediator subunits impacts metabolic homeostasis.
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