Journal
CELL METABOLISM
Volume 21, Issue 2, Pages 163-173Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2014.12.015
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Funding
- DUKE-NUS Graduate Medical School Singapore
- Goh foundation [DUKE-NUS/GRSF/2014/0002R]
- Spain Fund
- Cotswold Foundation
- [RO1 HL118768]
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Semaphorins were originally identified as neuronal guidance molecules mediating their attractive or repulsive signals by forming complexes with plexin and neuropilin receptors. Subsequent research has identified functions for semaphorin signaling in many organs and tissues outside of the nervous system. Vital roles for semaphorin signaling in vascular patterning and cardiac morphogenesis have been demonstrated, and impaired semaphorin signaling has been associated with various human cardiovascular disorders, including persistent truncus arteriosus, sinus bradycardia and anomalous pulmonary venous connections. Here, we review the functions of semaphorins and their receptors in cardiovascular development and disease and highlight important recent discoveries in the field.
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