Bioaccessibility and Intestinal Transport of Tebuconazole in Table Grape by Using In Vitro Digestion Models

In this study, the effects of various digestive models, influencing factors and dietary supplements on the bioaccessibility of tebuconazole in table grapes were compared. The Caco-2 cell model was employed to reveal the transfer behavior of tebuconazole. The results indicated that digestion time is the main factor affecting bioaccessibility. With an increase in time, the tebuconazole in grapes was almost completely dissolved, with bioaccessibility reaching 98.5%, whereas dietary fiber reduced bioaccessibility. Tebuconazole undergoes carrier-free passive transport in permeable cells in the Caco-2 cell model. These findings have practical application value for correctly evaluating the harmful level of pollutants in the matrix to human body.

Automated summary

This study compared the effects of different digestive models, factors, and dietary supplements on the bioaccessibility of tebuconazole in table grapes. The main factor affecting bioaccessibility was found to be digestion time, with dietary fiber reducing bioaccessibility. Tebuconazole was observed to undergo carrier-free passive transport in permeable cells in the Caco-2 cell model. These findings have practical implications for evaluating the harmful levels of pollutants in the matrix on the human body.