Journal
FOODS
Volume 11, Issue 23, Pages -Publisher
MDPI
DOI: 10.3390/foods11233783
Keywords
Agrocybe aegerita polysaccharides; anti-aging; antioxidant activity; gut microbiota
Categories
Funding
- Research Foundation for Youth Scholars of Beijing Technology and Business University [QNJJ2021-07]
- Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition [PXM2020-014213-000017]
- Natural Science Foundation of China [32172338]
- Technological Innovation Service Capacity Building-Basic Scientific Research Expenses [2021ERC02]
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The polysaccharides extracted from Agrocybe aegerita (AAPS) have been shown to have good antioxidant and potential anti-aging effects. The study demonstrated that AAPS could significantly prolong the lifespan of fruit flies, alleviate oxidative stress, and regulate gut microbiota.
Polysaccharides extracted from Agrocybe aegerita (AAPS) have various physiological effects. In this study, we used the naturally aging Drosophila melanogaster and D-galactose-induced aging mice as animal models to study the anti-aging effects of AAPS via the alleviation of oxidative stress and regulation of gut microbiota. Results showed that AAPS could significantly prolong lifespan and alleviate oxidative stress induced by H2O2 of Drosophila melanogaster. In addition, AAPS significantly increased the activities of antioxidant enzymes in Drosophila melanogaster and mice, and reduced the content of MDA. Furthermore, AAPS reshaped the disordered intestinal flora, increased the abundance ratio of Firmicutes to Bacteroidetes, and increased the abundance of beneficial bacteria Lactobacillus. Our results demonstrated that AAPS had good antioxidant and potential anti-aging effects in vivo.
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