4.7 Article

Immunometabolic involvement of hepcidin genes in iron homeostasis, storage, and regulation in gilthead seabream (Sparus aurata)

Related references

Note: Only part of the references are listed.
Article Fisheries

Massive gene expansion of hepcidin, a host defense peptide, in gilthead seabream (Sparus aurata)

Jhon A. Serna-Duque et al.

Summary: Host defense peptides, particularly hepcidins, play a crucial role in the innate immune system of vertebrates. The study on hepcidins in gilthead seabream revealed a massive duplication of hamp genes on chromosome 17, suggesting high adaptation and diversity within this species. Additionally, the research indicated different immune roles for hepcidins in seabream and showcased specific-tissue expression profiles in response to bacterial challenge, potentially leading to a deeper understanding of innate immunity in fish and vertebrates.

FISH & SHELLFISH IMMUNOLOGY (2022)

Article Fisheries

Sequence analysis of hepcidin in barbel steed (Hemibarbus labeo): QSHLS motif confers hepcidin iron-regulatory activity but limits its antibacterial activity

Jie Chen et al.

Summary: Fish hepcidin genes are classified into two groups: hamp1-type and hamp2-type, with hamp1-type exhibiting iron-regulatory activity. The study identified an iron-regulatory motif in barbel steed hepcidin and showed that this motif confers hamp1-type hepcidin iron-regulatory activity while attenuating its antibacterial activity.

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

The role of cellular iron deficiency in controlling iron export

Camille Link et al.

Summary: Iron deficiency delays hepcidin-induced Fpn degradation when cytosolic iron levels are low, indicating that iron export is necessary for efficient targeting of Fpn by hepcidin. Additionally, Fpn degradation is not involved in protecting cells from intracellular iron deficiency.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2021)

Article Veterinary Sciences

Limiting access to iron decreases infection of Atlantic salmon SHK-1 cells with bacterium Piscirickettsia salmonis

Rodrigo Diaz et al.

Summary: The iron chelator DFO had a negative impact on bacterial load and cytotoxicity in Atlantic salmon SHK-1 cells infected with P. salmonis. This resulted in increased expression of immune genes in the infected cells, leading to a more protective response against the infection.

BMC VETERINARY RESEARCH (2021)

Review Biochemistry & Molecular Biology

On Iron Metabolism and Its Regulation

Anne-Cathrine S. Vogt et al.

Summary: Iron is crucial for biological processes and is mainly bound to hemoglobin in red blood cells. It is recycled from senescent cells by macrophages and regulated by hormones like hepcidin. Key proteins like DMT1 and FPN play crucial roles in iron uptake and transport.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biotechnology & Applied Microbiology

Iron uptake mechanisms as key virulence factors in bacterial fish pathogens

M. L. Lemos et al.

JOURNAL OF APPLIED MICROBIOLOGY (2020)

Article Fisheries

Effects of dietary Origanum vulgare on gilthead seabream (Sparus aurata L.) immune and antioxidant status

José María García Beltrán et al.

FISH & SHELLFISH IMMUNOLOGY (2020)

Article Environmental Sciences

Heavy metal contamination in a highly consumed Brazilian fish: immunohistochemical and histopathological assessments

Lourenco Almeida Savassi et al.

ENVIRONMENTAL MONITORING AND ASSESSMENT (2020)

Article Multidisciplinary Sciences

Hamp1 but not Hamp2 regulates ferroportin in fish with two functionally distinct hepcidin types

Joao V. Neves et al.

SCIENTIFIC REPORTS (2017)

Article Biochemistry & Molecular Biology

Phylogenetic placement of enigmatic percomorph families (Teleostei: Percomorphaceae)

Millicent D. Sanciangco et al.

MOLECULAR PHYLOGENETICS AND EVOLUTION (2016)

Review Microbiology

Hepcidin and Host Defense against Infectious Diseases

Kathryn Michels et al.

PLOS PATHOGENS (2015)

Review Fisheries

Antimicrobial responses of teleost phagocytes and innate immune evasion strategies of intracellular bacteria

Leon Grayfer et al.

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2014)

Review Biochemistry & Molecular Biology

Insight into the evolution of the iron oxidation pathways

Marianne Ilbert et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2013)

Article Hematology

Body iron metabolism and pathophysiology of iron overload

Yutaka Kohgo et al.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2008)

Article Biochemistry & Molecular Biology

Heme, an iron supply for vibrios pathogenic for fish

Manuel L. Lemos et al.

BIOMETALS (2007)

Review Fisheries

Hepcidins in amphibians and fishes: Antimicrobial peptides or iron-regulatory hormones?

Jishu Shi et al.

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2006)

Article Biochemistry & Molecular Biology

Two different types of hepcidins from the Japanese flounder Paralichthys olivaceus

I Hirono et al.

FEBS JOURNAL (2005)

Article Veterinary Sciences

A model for acute iron overload in sea bass (Dicentrarchus labrax L.)

PNS Rodrigues et al.

LABORATORY ANIMALS (2004)

Review Medicine, General & Internal

Antibacterial peptides: basic facts and emerging concepts

HG Boman

JOURNAL OF INTERNAL MEDICINE (2003)