Journal
FRONTIERS IN MEDICINE
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmed.2022.1030336
Keywords
Acute-on-Chronic liver failure; liver transplantation; prognosis; APASL; EASL
Categories
Funding
- Science Foundations of Health Commission of Sichuan Province
- [20PJ180]
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Acute-on-Chronic liver failure (ACLF) is a clinical syndrome with high short-term mortality. Alcoholic ACLF is more prevalent in Europe and America, while hepatitis B virus (HBV)-related ACLF is more common in the Asia-Pacific region. Liver transplantation (LT) is currently the most effective treatment, but the shortage of liver sources limits its clinical application. This study reviews the literature on LT in the treatment of ACLF and discusses the challenges, timing, and patient selection for LT in ACLF.
Acute-on-Chronic liver failure (ACLF) is a clinical syndrome with high short-term mortality. Alcoholic ACLF is prevalent in European and American countries, while hepatitis B virus (HBV)-related ACLF is more common in the Asia-Pacific region. There is still a lack of a unified definition standard for ACLF, due to various etiologies and pathogeneses in different continents. Currently, liver transplantation (LT) is the most effective treatment for liver failure. However, the shortage of liver sources is still a global problem, which seriously limits the clinical application of an LT. Premature LT aggravates the shortage of liver resources to a certain extent, and too much delay significantly increases the risk of complications and death. Therefore, this study reviews the current literature on LT in the treatment of ACLF and discusses further the challenges for ACLF patients, the timing of LT for ACLF, and the choice of the patient population.
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