Journal
FRONTIERS IN MEDICINE
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmed.2022.1057252
Keywords
cancer immunosurveillance; IL-12; plasmacytoma; NK/NKT cells; IFN-gamma; TLR9; mesothelioma
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This study investigates the mechanisms by which the interaction between infectious agent molecules and early innate responses enhances the early inhibition of cancer growth, and specifically evaluates the role of Interleukin-12 (IL-12). The results show that CpG-protected mice against the early growth of plasmacytoma TEPC.1033.C2 cells through the ligation of toll-like receptor 9 (TLR9). This protection is dependent on IL-12 and gamma-interferon, and is confirmed in a model of early mesothelioma AB1 cell growth through the stimulation of TLR3 and TLR7/8.
Introduction: Natural prevention of cancer development depends on an efficient immunosurveillance that may be modulated by environmental factors, including infections. Innate lymphoid cytotoxic cells have been shown to play a major role in this immunosurveillance. Interleukin-12 (IL-12) has been suggested to be a key factor in the activation of innate cytotoxic cells after infection, leading to the enhancement of cancer immunosurveillance. Methods: The aim of this work was to analyze in mouse experimental models by which mechanisms the interaction between infectious agent molecules and the early innate responses could enhance early inhibition of cancer growth and especially to assess the role of IL-12 by using novel antibodies specific for IL-12 heterodimers. Results: Ligation of toll-like receptor (TLR)9 by CpG-protected mice against plasmacytoma TEPC.1033.C2 cell early growth. This protection mediated by innate cytolytic cells was strictly dependent on IL-12 and partly on gamma-interferon. Moreover, the protective effect of CpG stimulation, and to a lesser extent of TLR3 and TLR7/8, and the role of IL-12 in this protection were confirmed in a model of early mesothelioma AB1 cell growth. Discussion: These results suggest that modulation of the mouse immune microenvironment by ligation of innate receptors deeply modifies the efficiency of cancer immunosurveillance through the secretion of IL-12, which may at least partly explain the inhibitory effect of previous infections on the prevalence of some cancers.
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