Case report: Cutaneous pseudolymphoma caused by a Leishmania infantum infection in a patient treated with anti-TNF antibody for plaque psoriasis

For psoriasis, which affects up to 2% of the population and adalimumab is approved from the age of 4 years. Here, we present a middle-aged Italian man with long-term history of plaque psoriasis and psoriasis arthropathica and adalimumab therapy. He developed ulcers or nodules within the psoriatic plaques, resembling cutaneous infection with Leishmania infantum. TNF and other cytokines such as IL-12 and IFN-gamma are central in the early control of the infection. Discontinuation of the anti-TNF-treatment resolved the infection without specific therapy.

Automated summary

This case report describes a middle-aged Italian man with a long-term history of plaque psoriasis and psoriasis arthropathica who developed ulcers or nodules resembling cutaneous infection with Leishmania infantum during adalimumab therapy. Discontinuation of the anti-TNF treatment resolved the infection without specific therapy.