Glycyrrhizic Acid Mitigates Tripterygium-Glycoside-Tablet-Induced Acute Liver Injury via PKM2 Regulated Oxidative Stress

Article Gastroenterology & Hepatology

FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2

Jianhua Rao et al.

Summary: This study found that macrophage FSTL1 promotes the progression of liver fibrosis by inducing M1 polarization and inflammation based on the intracellular PKM2 reprogramming function of macrophages.

GUT (2022)

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Article Pharmacology & Pharmacy

Transcriptome and Lipid Metabolomics-Based Discovery: Glycyrrhizic Acid Alleviates Tripterygium Glycoside Tablet-Induced Acute Liver Injury by Regulating the Activities of CYP and the Metabolism of Phosphoglycerides

Qiaoli Shi et al.

Summary: This study suggests that Glycyrrhizic acid can alleviate TGT-induced acute liver injury partly by regulating the activities of CYP and the metabolism of PC and PE.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Biology

Trehalose alleviates oxidative stress-mediated liver injury and Mallor-Denk body formation via activating autophagy in mice

Yuichi Honma et al.

Summary: Trehalose has shown beneficial effects on hepatocytes by inducing autophagy, reducing ER stress and oxidative stress, and improving cell survival, suggesting that it can become a therapeutic agent for oxidative stress-related liver diseases.

MEDICAL MOLECULAR MORPHOLOGY (2021)

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Review Biochemistry & Molecular Biology

Activity-Based Protein Profiling (ABPP) of Oxidoreductases

Rita Fuerst et al.

Summary: ABPP has been widely used for measuring protein activity, annotating unknown protein functions, and studying small-molecule inhibitor targets. Oxidoreductases have received less attention in ABPP, with probes developed for oxidases but none for reductases, presenting opportunities for future research.

CHEMBIOCHEM (2021)

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Article Pharmacology & Pharmacy

Clinical Practice Guideline for Tripterygium Glycosides/Tripterygium wilfordii Tablets in the Treatment of Rheumatoid Arthritis

Na Lin et al.

Summary: TwHF-based agents TGT and TWT are commonly used traditional Chinese herbal medicines for treating RA, but individual differences in patient responses may lead to ineffective treatment and risks of side effects, highlighting the need for a standardized clinical practice guideline.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

FXR activation prevents liver injury induced by Tripterygium wilfordii preparations

Wan Peng et al.

Summary: The study found that liver injury induced by Tripterygium glycosides tablets (TGT) and Tripterygium wilfordii tablets (TWT) was associated with bile acid metabolism disorder, with inhibition of the farnesoid X receptor (FXR) signalling pathway being a key factor. Treatment with the FXR agonist obeticholic acid (OCA) could alleviate liver injury by activating FXR to inhibit related pathways and improve bile acid metabolism disorder caused by Tripterygium wilfordii preparations.

XENOBIOTICA (2021)

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Article Biochemistry & Molecular Biology