Journal
METABOLITES
Volume 13, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/metabo13020207
Keywords
black raspberries; arsenic; gut microbiota; gut microbiome; metabolites
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Mounting evidence has shown that berries have various health benefits. This study demonstrated that the administration of black raspberries can change the gut microbiota and its functional metabolites, resulting in a reduction of arsenic-induced toxicity. These findings suggest that the interactions between black raspberries and arsenic exposure occur through the gut microbiota, and modulating the gut microbiota and its metabolites could contribute to the protective effects of black raspberries against arsenic toxicity.
Mounting evidence has linked berries to a variety of health benefits. We previously reported that administration of a diet rich in black raspberries (BRBs) impacted arsenic (As) biotransformation and reduced As-induced oxidative stress. To further characterize the role of the gut microbiota in BRB-mediated As toxicity, we utilized the dietary intervention of BRBs combined with a mouse model to demonstrate microbial changes by examining associated alterations in the gut microbiota, especially its functional metabolites. Results showed that BRB consumption changed As-induced gut microbial alterations through restoring and modifying the gut microbiome, including its composition, functions and metabolites. A number of functional metabolites in addition to bacterial genera were significantly altered, which may be linked to the effects of BRBs on arsenic exposure. Results of the present study suggest functional interactions between dietary administration of black raspberries and As exposure through the lens of the gut microbiota, and modulation of the gut microbiota and its functional metabolites could contribute to effects of administration of BRBs on As toxicity.
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