Journal
CELL METABOLISM
Volume 22, Issue 2, Pages 200-201Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2015.07.017
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Funding
- NIAAA NIH HHS [R21 AA022371] Funding Source: Medline
- NIGMS NIH HHS [T32 GM008629] Funding Source: Medline
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High adipose expression of NNMT, an enzyme that converts nicotinamide to 1-methyl-nicotinamide, correlates with adiposity. Though murine NNMT knockdown in fat and liver prevents weight gain on high-fat diet, Hong et al. (2015) now show that high hepatic expression of NNMT improves lipid parameters via SIRT1 stabilization.
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