Journal
FRONTIERS IN MOLECULAR BIOSCIENCES
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmolb.2022.1026848
Keywords
obstructive sleep apnea; metabolomics; gas chromatography-mass spectrometry; biomarkers; polysomnography
Categories
Funding
- Indian Council of Medical Research, Government of India
- CCRH-Ministry of AYUSH, Government of India
- KGMU intramural grant
- Indian Council of Medical Research, Government of India [5/4/2-9/Oral Health/2021-NCD-II]
Ask authors/readers for more resources
This study identified metabolic biomarkers and pathways associated with severe obstructive sleep apnea (OSA). The results showed significant alterations in metabolites and their related pathways in OSA patients compared to controls. The upregulation of specific metabolites related to chronic kidney disease, cardiovascular risk, and oxidative stress suggests their potential as biomarkers for disease management in OSA patients.
Objective: Obstructive sleep apnea (OSA) is considered a major sleep-related breathing problem with an increasing prevalence rate. Retrospective studies have revealed the risk of various comorbidities associated with increased severity of OSA. This study aims to identify novel metabolic biomarkers associated with severe OSA. Methods: In total, 50 cases of OSA patients (49.74 +/- 11.87 years) and 30 controls (39.20 +/- 3.29 years) were included in the study. According to the polysomnography reports and questionnaire-based assessment, only patients with an apnea-hypopnea index (AHI > 30 events/hour) exceeding the threshold representing severe OSA patients were considered for metabolite analysis. Plasma metabolites were analyzed using gas chromatography-mass spectrometry (GC-MS). Results: A total of 92 metabolites were identified in the OSA group compared with the control group after metabolic profiling. Metabolites and their correlated metabolic pathways were significantly altered in OSA patients with respect to controls. The fold-change analysis revealed markers of chronic kidney disease, cardiovascular risk, and oxidative stress-like indoxyl sulfate, 5-hydroxytryptamine, and 5-aminolevulenic acid, respectively, which were significantly upregulated in OSA patients. Conclusion: Identifying these metabolic signatures paves the way to monitor comorbid disease progression due to OSA. Results of this study suggest that blood plasma-based biomarkers may have the potential for disease management.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available