Journal
MICROORGANISMS
Volume 10, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/microorganisms10122435
Keywords
Leishmania; leishmaniasis; exoproteome; extracellular vesicles; secretome; vesicle-depleted exoproteome; exosomes
Categories
Funding
- Portuguese funds through FCT - Fundacao para a Ciencia e a Tecnologia [PTDC/CVT-CVT/6798/2020]
- FCT [SFRH/BD/140119/2018, SFRH/BD/140177/2018]
- European Social Fund within the Human Potential Operating Programme [2021.04285.CEECIND]
Ask authors/readers for more resources
Leishmaniasis is an important neglected tropical disease without vaccines, and the available chemotherapy is suboptimal. Understanding parasite biology is essential for developing new strategies for disease control. Studies on the exoproteome, especially extracellular vesicles, have provided valuable information on parasite survival, pathogenesis, and relevant processes.
Leishmaniasis, a vector-borne parasitic protozoan disease, is among the most important neglected tropical diseases. In the absence of vaccines, disease management is challenging. The available chemotherapy is suboptimal, and there are growing concerns about the emergence of drug resistance. Thus, a better understanding of parasite biology is essential to generate new strategies for disease control. In this context, in vitro parasite exoproteome characterization enabled the identification of proteins involved in parasite survival, pathogenesis, and other biologically relevant processes. After 2005, with the availability of genomic information, these studies became increasingly feasible and revealed the true complexity of the parasite exoproteome. After the discovery of Leishmania extracellular vesicles (EVs), most exoproteome studies shifted to the characterization of EVs. The non-EV portion of the exoproteome, named the vesicle-depleted exoproteome (VDE), has been mostly ignored even if it accounts for a significant portion of the total exoproteome proteins. Herein, we summarize the importance of total exoproteome studies followed by a special emphasis on the available information and the biological relevance of the VDE. Finally, we report on how VDE can be studied and disclose how it might contribute to providing biologically relevant targets for diagnosis, drug, and vaccine development.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available