The Contribution of the Human Oral Microbiome to Oral Disease: A Review

The oral microbiome is an emerging field that has been a topic of discussion since the development of next generation sequencing and the implementation of the human microbiome project. This article reviews the current literature surrounding the oral microbiome, briefly highlighting most recent methods of microbiome characterization including cutting edge omics, databases for the microbiome, and areas with current gaps in knowledge. This article also describes reports on microorganisms contained in the oral microbiome which include viruses, archaea, fungi, and bacteria, and provides an in-depth analysis of their significant roles in tissue homeostasis. Finally, we detail key bacteria involved in oral disease, including oral cancer, and the current research surrounding their role in stimulation of inflammatory cytokines, the role of gingival crevicular fluid in periodontal disease, the creation of a network of interactions between microorganisms, the influence of the planktonic microbiome and cospecies biofilms, and the implications of antibiotic resistance. This paper provides a comprehensive literature analysis while also identifying gaps in knowledge to enable future studies to be conducted.

Automated summary

This article reviews the current literature on the oral microbiome, including methods, databases, and knowledge gaps. It also provides a detailed analysis of the role of microorganisms in the oral microbiome, particularly in tissue homeostasis. Furthermore, it discusses key bacteria associated with oral diseases and their involvement in stimulating inflammatory cytokines, the role of gingival crevicular fluid in periodontal disease, microbial interaction networks, the influence of planktonic microbiome and cospecies biofilms, and implications of antibiotic resistance. The paper offers a comprehensive literature analysis and identifies knowledge gaps for future studies.