4.6 Article

Genome Characterization of Bacteriophage KPP-1, a Novel Member in the Subfamily Vequintavirinae, and Use of Its Endolysin for the Lysis of Multidrug-Resistant Klebsiella variicola In Vitro

Related references

Note: Only part of the references are listed.
Article Microbiology

Characterization of IncHI1B Plasmids Encoding Efflux Pump TmexCD2-ToprJ2 in Carbapenem-Resistant Klebsiella variicola, Klebsiella quasipneumoniae, and Klebsiella michiganensis Strains

Yujiao Wang et al.

Summary: The study reported three Klebsiella species strains carrying TmexCD2-ToprJ2, indicating the spread of this novel plasmid-mediated tigecycline resistance mechanism to different Klebsiella species. The co-occurrence of bla(NDM-1) and TmexCD2-ToprJ2 in the same plasmid is of particular public health concern.

FRONTIERS IN MICROBIOLOGY (2021)

Article Microbiology

Genomic Analysis of Prophages from Klebsiella pneumoniae Clinical Isolates

Andreia T. Marques et al.

Summary: This study analyzed 150 prophages from 40 clinical isolates of K. pneumoniae, revealing their impact on the evolution and phenotype of the bacteria. The prophages were found to be diverse and widely distributed in K. pneumoniae genomes, playing a role in conferring additional phenotypes and contributing to the evolution of this species. Additionally, endolysin genes were identified in K. pneumoniae prophages, coding for proteins with potential for lysin phage therapy.

MICROORGANISMS (2021)

Article Virology

A Roadmap for Genome-Based Phage Taxonomy

Dann Turner et al.

Summary: Bacteriophage taxonomy has been undergoing significant changes in recent years, with the abolition of certain classification units and the establishment of guidelines for delineating species, genus, subfamily, and family-level ranks in tailed phage taxonomy.

VIRUSES-BASEL (2021)

Article Microbiology

Toward a Phage Cocktail for Tuberculosis: Susceptibility and Tuberculocidal Action of Mycobacteriophages against Diverse Mycobacterium tuberculosis Strains

Carlos A. Guerrero-Bustamante et al.

Summary: Research suggests using bacteriophages may be a promising strategy for treating tuberculosis, with a five-phage cocktail effectively killing Mycobacterium tuberculosis strains without affecting antibiotic effectiveness. This offers new possibilities for treating tuberculosis and combating antibiotic resistance.
Article Multidisciplinary Sciences

Resistance patterns and clinical outcomes of Klebsiella pneumoniae and invasive Klebsiella variicola in trauma patients

John L. Kiley et al.

Summary: The recent reclassification of the Klebsiella genus to include Klebsiella variicola has raised concerns regarding its association with bacteremia and mortality. A study on Klebsiella spp. infections among battlefield trauma patients found that although K. variicola isolates were frequently isolated from bloodstream infections, they were less likely to be multidrug-resistant. Further research is needed to better understand the clinical significance of K. variicola in larger prospective studies.

PLOS ONE (2021)

Article Immunology

Bacteriophage Cocktails Protect Dairy Cows Against Mastitis Caused By Drug Resistant Escherichia coli Infection

Mengting Guo et al.

Summary: The study isolated three lytic phages from sewage of dairy farm, showing broad host range and high efficiency against E. coli. Phage cocktail significantly reduced bacterial number, somatic cells, and inflammatory factors in a mastitis infected cow model, achieving the same effect as antibiotic treatment. Overall, phage cocktail may be a promising alternative therapy against mastitis caused by drug resistant E. coli.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Article Chemistry, Medicinal

Development of Advanced Chimeric Endolysin to Control Multidrug-Resistant Staphylococcus aureus through Domain Shuffling

Chanyoung Lee et al.

Summary: By swapping different domains of natural Staphylococcus endolysins, a novel chimeric endolysin ClyC was constructed, showing enhanced lytic activity against S. aureus, strong antibacterial effects in milk and blood, and effective eradication of biofilms of multidrug-resistant bacteria. The chimeric endolysin also demonstrated protection against MRSA in a mouse infection model, suggesting its potential as an antibacterial agent against multidrug-resistant S. aureus.

ACS INFECTIOUS DISEASES (2021)

Review Infectious Diseases

Gram-Positive Pneumonia: Possibilities Offered by Phage Therapy

Lucia Fernandez et al.

Summary: Pneumonia, whether viral or bacterial, presents challenges to healthcare systems and effective antimicrobial strategies. Antibiotic resistance in bacterial pneumonia is a main concern, and alternative therapeutics like phage therapy may offer a solution. Regulatory hurdles and research difficulties remain obstacles to the clinical use of phage therapy.

ANTIBIOTICS-BASEL (2021)

Article Genetics & Heredity

GeneMark-HM: improving gene prediction in DNA sequences of human microbiome

Alexandre Lomsadze et al.

Summary: Computational reconstruction of metagenomic reads can identify thousands of uncultured candidate bacterial species, improving gene prediction accuracy in novel sequences. Testing of GeneMark-HM on simulated metagenomes showed enhanced gene annotation of human metagenomic sequences compared to current state-of-the-art tools.

NAR GENOMICS AND BIOINFORMATICS (2021)

Review Immunology

Phage Display Derived Monoclonal Antibodies: From Bench to Bedside

Mohamed A. Alfaleh et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Biotechnology & Applied Microbiology

Applications of phage-derived RNA-based technologies in synthetic biology

Wenhui Zhang et al.

SYNTHETIC AND SYSTEMS BIOTECHNOLOGY (2020)

Review Mathematical & Computational Biology

NCBI Taxonomy: a comprehensive update on curation, resources and tools

Conrad L. Schoch et al.

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2020)

Article Microbiology

Genome Sequences of 12 Phages That Infect Klebsiella pneumoniae

Trever L. Thurgood et al.

MICROBIOLOGY RESOURCE ANNOUNCEMENTS (2020)

Article Immunology

Klebsiella variicola: an emerging pathogen in humans

Nadia Rodriguez-Medina et al.

EMERGING MICROBES & INFECTIONS (2019)

Article Microbiology

Complete Genome Sequences of Two Klebsiella pneumoniae Phages Isolated as Part of an International Effort

Ortal Yerushalmy et al.

MICROBIOLOGY RESOURCE ANNOUNCEMENTS (2019)

Article Infectious Diseases

Post-surgical meningitis caused by Klebsiella variicola

Dai Akine et al.

IDCASES (2019)

Article Biotechnology & Applied Microbiology

Phage Therapy against &ITStreptococcus pneumoniae&IT: Modern Tool to Control Pneumonia

Muhammad Imran Qadir et al.

CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION (2017)

Article Biochemical Research Methods

ImageJ2: ImageJ for the next generation of scientific image data

Curtis T. Rueden et al.

BMC BIOINFORMATICS (2017)

Article Infectious Diseases

Fluorescein diacetate vital staining for detecting viability of acid-fast bacilli in patients on antituberculosis treatment

Swapna Kanade et al.

INTERNATIONAL JOURNAL OF MYCOBACTERIOLOGY (2016)

Letter Microbiology

An Investigation into Laboratory Misidentification of a Bloodstream Klebsiella variicola Infection

Gregory J. Berry et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2015)

Article Biochemical Research Methods

Prokka: rapid prokaryotic genome annotation

Torsten Seemann

BIOINFORMATICS (2014)

Article Biochemical Research Methods

Trimmomatic: a flexible trimmer for Illumina sequence data

Anthony M. Bolger et al.

BIOINFORMATICS (2014)

Article Biochemistry & Molecular Biology

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

Marco Biasini et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Biotechnology & Applied Microbiology

Bacteriophages BCP1-1 and BCP8-2 require divalent cations for efficient control of Bacillus cereus in fermented foods

Nadeeka Bandara et al.

FOOD MICROBIOLOGY (2012)

Article Microbiology

Introducing EzTaxon-e: a prokaryotic 16S rRNA gene sequence database with phylotypes that represent uncultured species

Ok-Sun Kim et al.

INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY (2012)

Article Biochemical Research Methods

SPAdes: A New Genome Assembly Algorithm and Its Applications to Single-Cell Sequencing

Anton Bankevich et al.

JOURNAL OF COMPUTATIONAL BIOLOGY (2012)

Article Biochemical Research Methods

Easyfig: a genome comparison visualizer

Mitchell J. Sullivan et al.

BIOINFORMATICS (2011)

Article Biotechnology & Applied Microbiology

The RAST server: Rapid annotations using subsystems technology

Ramy K. Aziz et al.

BMC GENOMICS (2008)

Article Biochemistry & Molecular Biology

Phylogeny.fr: robust phylogenetic analysis for the non-specialist

A. Dereeper et al.

NUCLEIC ACIDS RESEARCH (2008)

Article Biochemistry & Molecular Biology

The CGView Server: a comparative genomics tool for circular genomes

Jason R. Grant et al.

NUCLEIC ACIDS RESEARCH (2008)

Article Biochemical Research Methods

Identifying bacterial genes and endosymbiont DNA with Glimmer

Arthur L. Delcher et al.

BIOINFORMATICS (2007)

Article Biochemistry & Molecular Biology

InterProScan: protein domains identifier

E Quevillon et al.

NUCLEIC ACIDS RESEARCH (2005)

Article Biochemical Research Methods

CLANS: a Java application for visualizing protein families based on pairwise similarity

T Frickey et al.

BIOINFORMATICS (2004)

Article Biochemistry & Molecular Biology

ARAGORN, a program to detect tRNA genes and tmRNA genes in nucleotide sequences

D Laslett et al.

NUCLEIC ACIDS RESEARCH (2004)

Review Microbiology

Bacteriophage therapy of infectious diseases in aquaculture

T Nakai et al.

RESEARCH IN MICROBIOLOGY (2002)