4.6 Review

Environmental Neurotoxin β-N-Methylamino-L-alanine (BMAA) as a Widely Occurring Putative Pathogenic Factor in Neurodegenerative Diseases

Related references

Note: Only part of the references are listed.
Article Cell Biology

Na+/Ca2+ exchanger isoform 1 takes part to the Ca2+-related prosurvival pathway of SOD1 in primary motor neurons exposed to beta-methylamino-L-alanine

Tiziana Petrozziello et al.

Summary: The study revealed that SOD1 and ApoSOD1 exert their neuroprotective effects by modulating ER Ca2+ content through the activation of NCX1 reverse mode and promoting Akt nuclear translocation in a subset of primary motor neurons.

CELL COMMUNICATION AND SIGNALING (2022)

Review Neurosciences

Soluble TREM2: Innocent bystander or active player in neurological diseases?

Fabia Filipello et al.

Summary: This article reviews the role of TREM2, focusing on its potential functions as a biomarker in neurological disorders and as a potential therapeutic target for CNS diseases.

NEUROBIOLOGY OF DISEASE (2022)

Article Food Science & Technology

Assessment of Common Cyanotoxins in Cyanobacteria of Biological Loess Crusts

Tamara Dulic et al.

Summary: This study investigated the production of cyanotoxins in biological loess crusts and cyanobacterial cultures. The results showed no detection of targeted cyanotoxins or cyanotoxin-encoding genes in the samples.

TOXINS (2022)

Article Food Science & Technology

Occurrence of BMAA Isomers in Bloom-Impacted Lakes and Reservoirs of Brazil, Canada, France, Mexico, and the United Kingdom

Safa Abbes et al.

Summary: This study evaluated the impact of trichloroacetic acid on the detection of BMAA isomers in lake water samples and found that its addition significantly increased detection rates and levels. Additionally, an investigation of lakes from multiple countries revealed a higher occurrence of AEG and DAB isomers compared to BAMA and BMAA.

TOXINS (2022)

Review Food Science & Technology

Non-Proteinogenic Amino Acid β-N-Methylamino-L-Alanine (BMAA): Bioactivity and Ecological Significance

Olga A. Koksharova et al.

Summary: This review examines the connection between the non-protein amino acid BMAA and neurodegenerative diseases. It provides a detailed analysis of the molecular mechanisms underlying the toxicity of BMAA and its effects on cyanobacterial cells.

TOXINS (2022)

Review Medicine, Research & Experimental

Environmental bacteria as triggers to brain disease: Possible mechanisms of toxicity and associated human risk

Audrey Courtier et al.

Summary: This review discusses the role of environmental bacteria in brain diseases, focusing on the impact of environmental bacterial compounds and toxicity related to bacterial infections. Findings reveal that environmental bacteria can cause brain damage through multiple toxicological pathways, emphasizing the need for further research to clarify cocktail effects and potential new intervention targets.

LIFE SCIENCES (2022)

Article Neurosciences

Biocrust-Produced Cyanotoxins Are Found Vertically in the Desert Soil Profile

Aspassia D. Chatziefthimiou et al.

Summary: The study investigated the distribution of BMAA and its isomers in desert soil, finding that these toxins were detected at different depths in soil samples, with AEG and DAB being quantifiable while BMAA was considered below the quantification threshold. These findings have potential environmental health implications if the toxins contaminate aquifers and impact human and animal health through exposure to contaminated groundwater or inhalation of aerosolized soil particles.

NEUROTOXICITY RESEARCH (2021)

Review Pharmacology & Pharmacy

An Insight Into Mitochondrial Dysfunction and its Implications in Neuro-logical Diseases

Rashid Waseem et al.

Summary: There has been a growing focus on the role of mitochondria in neurodegenerative disorders, with evidence pointing to mitochondrial dysfunction as a key player in the pathology of diseases such as Alzheimer's, Parkinson's, and ALS. Mitochondria play crucial roles in cellular processes and their dysfunction can have implications in various pathological conditions.

CURRENT DRUG TARGETS (2021)

Article Toxicology

BMAA and MCLR Interact to Modulate Behavior and Exacerbate Molecular Changes Related to Neurodegeneration in Larval Zebrafish

Rubia M. Martin et al.

Summary: The study evaluated the neurotoxic effects of a mixture of two co-occurring cyanotoxins, BMAA and MCLR, using the larval zebrafish model. The results showed that the mixture enhanced neurotoxicity and affected the acoustic startle sensitivity of zebrafish larvae.

TOXICOLOGICAL SCIENCES (2021)

Review Neurosciences

Is Exposure to BMAA a Risk Factor for Neurodegenerative Diseases? A Response to a Critical Review of the BMAA Hypothesis

R. A. Dunlop et al.

Summary: Chernoff et al. criticize the hypothesis of BMAA exposure as a risk factor for neurodegenerative diseases, pointing out errors in their critique such as selective citation of literature and misattribution of methods. Although uncertainties exist in the research field of chronic exposure to BMAA causing neurodegenerative diseases, an increasing body of evidence suggests this possibility.

NEUROTOXICITY RESEARCH (2021)

Article Pharmacology & Pharmacy

Neurotoxicity of isomers of the environmental toxin L-BMAA

Thomas Schneider et al.

TOXICON (2020)

Article Multidisciplinary Sciences

Cyanobacterial neurotoxin BMAA and brain pathology in stranded dolphins

David A. Davis et al.

PLOS ONE (2019)

Article Multidisciplinary Sciences

Insufficient evidence for BMAA transfer in the pelagic and benthic food webs in the Baltic Sea

Nadezda Zguna et al.

SCIENTIFIC REPORTS (2019)

Article Food Science & Technology

Production of β-methylamino-L-alanine (BMAA) and Its Isomers by Freshwater Diatoms

Jake P. Violi et al.

TOXINS (2019)

Article Neurosciences

Disease-Modification in Huntington's Disease: Moving Away from a Single-Target Approach

Melanie P. Jensen et al.

JOURNAL OF HUNTINGTONS DISEASE (2019)

Article Neurosciences

Neurotoxicity of the Cyanotoxin BMAA Through Axonal Degeneration and Intercellular Spreading

Vanessa X. Tan et al.

NEUROTOXICITY RESEARCH (2018)

Article Neurosciences

The Evaluation of BMAA Inhalation as a Potential Exposure Route Using a rat Model

Laura Louise Scott et al.

NEUROTOXICITY RESEARCH (2018)

Article Food Science & Technology

-N-Methylamino-l-alanine (BMAA) Toxicity Is Gender and Exposure-Age Dependent in Rats

Laura Louise Scott et al.

TOXINS (2018)

Review Cell Biology

Calcium signaling and molecular mechanisms underlying neurodegenerative diseases

Ekaterina Pchitskaya et al.

CELL CALCIUM (2018)

Review Biochemistry & Molecular Biology

Pathomechanisms of TDP-43 in neurodegeneration

Ju Gao et al.

JOURNAL OF NEUROCHEMISTRY (2018)

Article Pharmacology & Pharmacy

Disposition of beta-N-methylamino-L-alanine (L-BMAA), a neurotoxin, in rodents following a single or repeated oral exposure

Suramya Waidyanatha et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)

Article Pharmacology & Pharmacy

BMAA-protein interactions: A possible new mechanism of toxicity

R. van Onselen et al.

TOXICON (2018)

Review Neurosciences

Autophagy and Mitochondria: Targets in Neurodegenerative Disorders

Ashutosh Kumar et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2018)

Review Biotechnology & Applied Microbiology

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

Barry Boland et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Review Cell Biology

A new era for understanding amyloid structures and disease

Matthew G. Iadanza et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Review Biochemistry & Molecular Biology

The Role of NADPH Oxidases and Oxidative Stress in Neurodegenerative Disorders

Anuradha Tarafdar et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biotechnology & Applied Microbiology

Screening of BMAA-producing cyanobacteria in cultured isolates and in in situ blooms

Marta Monteiro et al.

JOURNAL OF APPLIED PHYCOLOGY (2017)

Article Neurosciences

Cytotoxic Effects of Environmental Toxins on Human Glial Cells

Fiona D'Mello et al.

NEUROTOXICITY RESEARCH (2017)

Review Environmental Sciences

Metals and neurodegenerative diseases. A systematic review

Calogero Edoardo Cicero et al.

ENVIRONMENTAL RESEARCH (2017)

Review Environmental Sciences

A critical review of the postulated role of the non-essential amino acid, β-N-methylamino-L-alanine, in neurodegenerative disease in humans

N. Chernoff et al.

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2017)

Review Biochemistry & Molecular Biology

Microglia emerge as central players in brain disease

Michael W. Salter et al.

NATURE MEDICINE (2017)

Article Biochemistry & Molecular Biology

50 years of research on α-amino-β-methylaminopropionic acid (β-methylaminoalanine)

Peter B. Nunn

PHYTOCHEMISTRY (2017)

Article Food Science & Technology

Detection of Cyanotoxins in Algae Dietary Supplements

Audrey Roy-Lachapelle et al.

TOXINS (2017)

Review Biochemistry & Molecular Biology

Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies

Anna Villar-Pique et al.

JOURNAL OF NEUROCHEMISTRY (2016)

Review Multidisciplinary Sciences

How neuroinflammation contributes to neurodegeneration

Richard M. Ransohoff

SCIENCE (2016)

Article Multidisciplinary Sciences

β-methylamino-L-alanine (BMAA) is not found in the brains of patients with confirmed Alzheimer's disease

Julie P. Meneely et al.

SCIENTIFIC REPORTS (2016)

Review Geriatrics & Gerontology

Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases

Qiuyang Zheng et al.

FRONTIERS IN AGING NEUROSCIENCE (2016)

Article Food Science & Technology

Cyanobacterial Neurotoxin BMAA and Mercury in Sharks

Neil Hammerschlag et al.

TOXINS (2016)

Article Biochemical Research Methods

Determination of BMAA and three alkaloid cyanotoxins in lake water using dansyl chloride derivatization and high-resolution mass spectrometry

Audrey Roy-Lachapelle et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2015)

Article Environmental Sciences

Morphometric and neurochemical alterations found in L-BMAA treated rats

Estefania de Munck et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2015)

Article Ecology

The persistence of cyanobacterial toxins in desert soils

Renee Richer et al.

JOURNAL OF ARID ENVIRONMENTS (2015)

Article Ecology

Neurotoxic amino acids and their isomers in desert environments

J. S. Metcalf et al.

JOURNAL OF ARID ENVIRONMENTS (2015)

Article Chemistry, Medicinal

Biotransfer of β-N-Methylamino-l-alanine (BMAA) in a Eutrophicated Freshwater Lake

Sandra Lage et al.

MARINE DRUGS (2015)

Article Neurosciences

Analysis of β-N-methylamino-L-alanine (L-BMAA) neurotoxicity in rat cerebellum

Emma Munoz-Saez et al.

NEUROTOXICOLOGY (2015)

Article Food Science & Technology

Environmental neurotoxins β-N-methylamino-L-alanine (BMAA) and mercury in shark cartilage dietary supplements

Kiyo Mondo et al.

FOOD AND CHEMICAL TOXICOLOGY (2014)

Article Multidisciplinary Sciences

Diatoms: A Novel Source for the Neurotoxin BMAA in Aquatic Environments

Liying Jiang et al.

PLOS ONE (2014)

Article Multidisciplinary Sciences

Tau pathology involves protein phosphatase 2A in Parkinsonism-dementia of Guam

Mohammad Arif et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Quantification of neurotoxin BMAA (β-N-methylamino-L-alanine) in seafood from Swedish markets

Liying Jiang et al.

SCIENTIFIC REPORTS (2014)

Review Food Science & Technology

Presence of the Neurotoxin BMAA in Aquatic Ecosystems: What Do We Really Know?

Elisabeth J. Faassen

TOXINS (2014)

Article Biochemical Research Methods

Strategy for quantifying trace levels of BMAA in cyanobacteria by LC/MS/MS

Liying Jiang et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2013)

Review Public, Environmental & Occupational Health

HUMAN EXPOSURE TO CYANOTOXINS AND THEIR EFFECTS ON HEALTH

Damjana Drobac et al.

ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY (2013)

Article Toxicology

^|^beta;-N-methylamino-L-alanine induces changes in both GSK3 and TDP-43 in human neuroblastoma

Emma Mu^|^ntilde;oz-Saez et al.

JOURNAL OF TOXICOLOGICAL SCIENCES (2013)

Article Multidisciplinary Sciences

Gliotoxicity of the cyanotoxin, β-methyl-amino-L-alanine (BMAA)

Alexander S. Chiu et al.

SCIENTIFIC REPORTS (2013)

Article Biochemistry & Molecular Biology

The non-protein amino acid β-N-methylamino-L-alanine in Portuguese cyanobacterial isolates

Rosa C. Cervantes Cianca et al.

AMINO ACIDS (2012)

Article Limnology

Detection and quantification of β-methylamino-L-alanine in aquatic invertebrates

Stephanie J. Christensen et al.

LIMNOLOGY AND OCEANOGRAPHY-METHODS (2012)

Article Chemistry, Medicinal

Cyanobacterial Neurotoxin β-N-Methylamino-L-alanine (BMAA) in Shark Fins

Kiyo Mondo et al.

MARINE DRUGS (2012)

Article Geriatrics & Gerontology

Weak BMAA toxicity compares with that of the dietary supplement beta-alanine

Moonhee Lee et al.

NEUROBIOLOGY OF AGING (2012)

Review Environmental Sciences

Controlling harmful cyanobacterial blooms in a world experiencing anthropogenic and climatic-induced change

Hans W. Paerl et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2011)

Article Chemistry, Analytical

Analytical protocol for identification of BMAA and DAB in biological samples

Zdenek Spacil et al.

ANALYST (2010)

Article Multidisciplinary Sciences

Transfer of a cyanobacterial neurotoxin within a temperate aquatic ecosystem suggests pathways for human exposure

Sara Jonasson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Clinical Neurology

Cyanobacterial neurotoxin BMAA in ALS and Alzheimer's disease

J. Pablo et al.

ACTA NEUROLOGICA SCANDINAVICA (2009)

Article Clinical Neurology

Toxicity of the cyanobacterial neurotoxin beta-N-methylamino-L-alanine to three aquatic animal species

Esme L. Purdie et al.

AMYOTROPHIC LATERAL SCLEROSIS (2009)

Article Clinical Neurology

Cyanobacteria and BMAA exposure from desert dust: A possible link to sporadic ALS among Gulf War veterans

Paul Alan Cox et al.

AMYOTROPHIC LATERAL SCLEROSIS (2009)

Article Biochemistry & Molecular Biology

Augmentation and ionic mechanism of effect of β-N-methylamino-L-alanine in presence of bicarbonate on membrane potential of Retzius nerve cells of the leech Haemopis sanguisuga

Srdjan Lopicic et al.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY (2009)

Article Environmental Sciences

beta-N-methylamino-L-alanine (BMAA) in novel South African cyanobacterial isolates

M. Esterhuizen et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2008)

Article Neurosciences

Beta-methylarnino-alanine (BMAA) injures hippocampal neurons in vivo

Eric J. Buenz et al.

NEUROTOXICOLOGY (2007)

Article Neurosciences

β-N-methylamino-L-alanine enhances neurotoxicity through multiple mechanisms

Doug Lobner et al.

NEUROBIOLOGY OF DISEASE (2007)

Article Neurosciences

BMAA selectively injures motor neurons via AMPA/kainate receptor activation

Shyam D. Rao et al.

EXPERIMENTAL NEUROLOGY (2006)

Article Behavioral Sciences

Lack of behavioral and neuropathological effects of dietary β-methylamino-L-alanine (BMAA) in mice

Reyniel Cruz-Aguado et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2006)

Article Multidisciplinary Sciences

Diverse taxa of cyanobacteria produce β-N-methylamino-L-alanine, a neurotoxic amino acid

PA Cox et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

A mechanism for slow release of biomagnified cyanobacterial neurotoxins and neurodegenerative disease in Guam

SJ Murch et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Multidisciplinary Sciences

Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam

PA Cox et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)