Rapid Identification of Relevant Microbial Strains by Identifying Multiple Marker Single Nucleotide Polymorphisms via Amplicon Sequencing: Epidemic Monkeypox Virus as a Proof of Concept

Article Genetics & Heredity

Global landscape of SARS-CoV-2 genomic surveillance and data sharing

Zhiyuan Chen et al.

Summary: This study analyzed global SARS-CoV-2 genomic surveillance and genomic data, finding significant variations in surveillance and sequencing capabilities among different countries. It also identified heterogeneity in sequencing percentage, sequencing technologies, turnaround time, and completeness of released metadata across regions and income groups. Moreover, it revealed a lack of proactive sharing of sequences related to variant of concerns (VOCs) in public repositories by some countries. Urgent actions are required to enhance timely and full sharing of sequences, standardize metadata files, and support countries with limited sequencing and bioinformatics capacity.

NATURE GENETICS (2022)

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Article Biochemistry & Molecular Biology

Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus

Joana Isidro et al.

Summary: In this study, shotgun metagenomics were used to rapidly reconstruct and characterize the genome sequences of the largest monkeypox virus outbreak in non-endemic countries so far. The findings indicate that the outbreak most likely has a single origin and that the virus belongs to clade 3. Furthermore, the study suggests the involvement of host APOBEC3 in viral evolution and reveals signs of ongoing microevolution in the virus.

NATURE MEDICINE (2022)

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Article Public, Environmental & Occupational Health

Phylogenomic analysis of the monkeypox virus (MPXV) 2022 outbreak: Emergence of a novel viral lineage?

Nicolas Luna et al.

Summary: Since May 13, 2022, there has been an increasing number of suspected and confirmed cases of monkeypox reported in non-endemic regions worldwide. Analysis of the virus genomes revealed three distinct clades, including a newly emerging clade from the 2022 outbreak. The surge in cases and widespread geographical spread suggest multiple factors driving the current outbreak dynamics.

TRAVEL MEDICINE AND INFECTIOUS DISEASE (2022)

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Article Public, Environmental & Occupational Health

Travel Medicine and Infectious Disease

Darwin A. Leon-Figueroa et al.

Summary: This article discusses the ongoing emergence of various viral zoonoses after the COVID-19 pandemic, with a particular focus on the increasing concern of monkeypox in Europe, North America, and other regions.

TRAVEL MEDICINE AND INFECTIOUS DISEASE (2022)

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Review Infectious Diseases