Journal
ANTIOXIDANTS
Volume 11, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/antiox11122360
Keywords
fumonisin B1; pterostilbene; alveolar macrophage; cytotoxicity; JAK; STAT signaling pathway; pig
Funding
- Seed Industry Vitalization Research Projects of Jiangsu Province [JBGS [2021]098]
- Key Research and Development Project (Modern Agriculture) of Jiangsu Province [BE2019341]
- Qing Lan Project of Yangzhou University
- Priority Academic Program Development of Jiangsu Higher Education Institution
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This study investigated the cytotoxicity induced by FB1 and explored the potential alleviating effect of PTE. The findings showed that FB1 induced cytotoxicity, apoptosis, pro-inflammatory cytokine production, and mitochondrial damage, which could be largely recovered by PTE treatment. Mechanistically, FB1 activated the JAK/STAT signaling pathway, while PTE attenuated FB1-induced cytotoxicity by inhibiting key JAK/STAT genes.
Fumonisin B1 (FB1) is a mycotoxin that poses a great threat to agricultural production and the health of humans and animals. Pterostilbene (PTE) is a natural plant polyphenolic compound with good anti-inflammatory, antioxidant and cell regeneration effects, yet its effectiveness in treating FB1-induced cytotoxicity remains to be explored. In this study, we used porcine alveolar macrophages (3D4/21) as a model to characterize the cytotoxicity induced by FB1, and to investigate the potential alleviating effect of PTE on FB1-induced cytotoxicity. We demonstrate that FB1 induces cytotoxicity, apoptosis, pro-inflammatory cytokine production and mitochondrial damage, which can be largely recovered by PTE treatment, suggesting the promising application of PTE to treat FB1-induced damage. Mechanistically, FB1 activates the JAK/STAT signaling pathway, while PTE attenuates FB1-induced cytotoxicity through the inhibition of key JAK/STAT genes such as JAK2 and STAT3. Overall, our study characterized the molecular mechanism for FB1-induced cytotoxicity and found PTE to be a promising component which can alleviate FB1-induced cytotoxicity by interfering in the activation of JAK/STAT pathway.
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