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Cell Biology
Yi Yu et al.
Summary: Ferroptosis is a newly identified iron-dependent cell death mechanism that differs from other cell death pathways, characterized by lipid peroxidation and accumulation of redox-active iron. Studies suggest that ferroptosis plays a crucial role in various cardiovascular diseases, and targeting ferroptosis may present a novel therapeutic approach in treating these conditions.
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Xuejun Jiang et al.
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Mihaela Ionescu et al.
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Pharmacology & Pharmacy
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Cell Biology
Xin Chen et al.
Summary: The induction and consequences of regulated cell death (RCD) result in changes in gene and protein expression, biochemical pathways, cell morphology, and size. Among different forms of RCD, ferroptosis, driven by iron overload and lipid peroxidation, is implicated in various pathological conditions and diseases. The ferroptotic response can be fine-tuned through oxidative stress and antioxidant pathways, and a series of inducers or inhibitors have been developed targeting metabolism-related proteins.
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Summary: Ferroptosis is an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, and can be induced by various agents to suppress tumor growth while also potentially triggering inflammation-associated immunosuppression. The extent of ferroptosis's impact on tumor biology and its interactions with other signaling pathways are still under investigation.
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Endocrinology & Metabolism
Florentina Duica et al.
Summary: PCOS is a complex disorder affecting 5% to 10% of women worldwide, with cardiovascular comorbidities such as endothelial dysfunction and atherosclerosis. Oxidative stress plays a key role in increasing CVD risk among PCOS patients, highlighting the potential benefits of antioxidant therapy.
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Microbiology
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Summary: COVID-19, caused by SARS-CoV-2, is a global pandemic with severe cases manifesting as acute respiratory distress syndrome, often in patients with underlying conditions. Rapid progression of the disease is mainly attributed to hyperinflammation and a lack of interferon response in the early stages.
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Cell Biology
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Cell Biology
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Md. Jakaria et al.
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Cell Biology
Pasquale Mone et al.
Summary: The study demonstrates the detrimental effects of hypertension and hyperglycemia on endothelial cell function and cognitive decline in older adults. Metformin shows beneficial effects on brain microvascular endothelial cells, improving cell death and reactive oxygen species generation induced by high glucose, and mitigating cognitive impairment.
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Multidisciplinary Sciences
Xianjin Kan et al.
Summary: Several new cell death processes have been discovered in recent years, with ferroptosis having a tumor-suppressor function and potential for treating therapy-resistant cancers. The mechanism by which ferroptosis mediates the response of tumor cells to oncolytic viruses remains poorly understood. The Newcastle disease virus can induce ferroptosis in tumor cells through the p53-SLC7A11-GPX4 pathway, highlighting the critical role of viruses in killing tumor cells.
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Medicine, Research & Experimental
Wenjing Zhang et al.
Summary: RBMS1 is a key regulator of ferroptosis in lung cancer development and its high expression is associated with reduced patient survival. Depletion or inhibition of RBMS1 can promote ferroptosis and sensitize radioresistant lung cancer cells to radiotherapy. RBMS1 interacts with eIF3d to regulate translation of SLC7A11, playing a critical role in ferroptosis evasion during lung cancer progression.
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(2021)
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Critical Care Medicine
Jessica Gambardella et al.
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Immunology
Aldo Bonaventura et al.
Summary: The authors suggest that SARS-CoV-2 infection induces a prothrombotic state and dysregulated immunothrombosis, leading to severe manifestations of COVID-19. They also discuss potential antithrombotic and immunomodulating drugs for treating COVID-19 patients, aiming to reduce the acute and long-term consequences of the disease by targeting immunothrombosis.
NATURE REVIEWS IMMUNOLOGY
(2021)
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Biochemistry & Molecular Biology
Pasquale Mone et al.
Summary: Neuropilin-1 is involved in various biological processes such as angiogenesis and immunity. A specific microRNA, miR-24, has been identified as a regulator of Neuropilin-1 transcription. Functional studies in human brain microvascular endothelial cells have validated miR-24 as a modulator of Neuropilin-1 function.
Review
Cell Biology
Hai Wang et al.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2020)
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Medicine, General & Internal
Chaolin Huang et al.
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Cardiac & Cardiovascular Systems
Xuexian Fang et al.
CIRCULATION RESEARCH
(2020)
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Biochemistry & Molecular Biology
Giovanni Miotto et al.
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Medicine, Research & Experimental
Guang Chen et al.
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(2020)
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Medicine, General & Internal
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NEW ENGLAND JOURNAL OF MEDICINE
(2020)
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Biochemistry & Molecular Biology
Victor J. Costela-Ruiz et al.
CYTOKINE & GROWTH FACTOR REVIEWS
(2020)
Review
Cardiac & Cardiovascular Systems
Paul C. Evans et al.
CARDIOVASCULAR RESEARCH
(2020)
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Physiology
Savneet Kaur et al.
FRONTIERS IN PHYSIOLOGY
(2020)
Review
Medicine, General & Internal
Maria Giovanna Scioli et al.
JOURNAL OF CLINICAL MEDICINE
(2020)
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Cell Biology
Anna Martina Battaglia et al.
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Biochemistry & Molecular Biology
Francesca Silvagno et al.
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Aakriti Gupta et al.
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Biochemistry & Molecular Biology
Diane Marie Del Valle et al.
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Antonella Fara et al.
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Endocrinology & Metabolism
Fu Gui et al.
FRONTIERS IN ENDOCRINOLOGY
(2020)
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Endocrinology & Metabolism
Colm J. McElwain et al.
FRONTIERS IN ENDOCRINOLOGY
(2020)
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Cardiac & Cardiovascular Systems
Werner Jacobs et al.
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Biochemistry & Molecular Biology
B. Chernyak et al.
BIOCHEMISTRY-MOSCOW
(2020)
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Oncology
Dulguun Amgalan et al.
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Biochemistry & Molecular Biology
Riccardo Turchi et al.
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Cell Biology
Bartosz Wiernicki et al.
CELL DEATH & DISEASE
(2020)
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Biochemistry & Molecular Biology
Alessandro Matarese et al.
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Peripheral Vascular Disease
Jessica Gambardella et al.
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Multidisciplinary Sciences
Weimin Wang et al.
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Multidisciplinary Sciences
Sebastian Doll et al.
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Multidisciplinary Sciences
Kirill Bersuker et al.
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Biochemistry & Molecular Biology
Minghui Gao et al.
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Cardiac & Cardiovascular Systems
Alexander Kushnir et al.
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Cell Biology
Gaetano Santulli
Science Translational Medicine
(2018)
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Multidisciplinary Sciences
Eran Agmon et al.
SCIENTIFIC REPORTS
(2018)
Review
Endocrinology & Metabolism
Karoline de Sousa Ronconi et al.
FRONTIERS IN ENDOCRINOLOGY
(2018)
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Chemistry, Multidisciplinary
Omkar Zilka et al.
ACS CENTRAL SCIENCE
(2017)
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Multidisciplinary Sciences
Bettina P. Mihalas et al.
SCIENTIFIC REPORTS
(2017)
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Gastroenterology & Hepatology
Xiaofang Sun et al.
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Cardiac & Cardiovascular Systems
Andrew O. Odegaard et al.
CARDIOVASCULAR DIABETOLOGY
(2016)
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Multidisciplinary Sciences
Yang Ou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
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Multidisciplinary Sciences
Gaetano Santulli et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
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Oncology
Min-Young Kwon et al.
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Multidisciplinary Sciences
Wenjun Xie et al.
SCIENTIFIC REPORTS
(2015)
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Multidisciplinary Sciences
Ersilia Cipolletta et al.
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Medicine, Research & Experimental
Gaetano Santulli et al.
JOURNAL OF CLINICAL INVESTIGATION
(2014)
Review
Cardiac & Cardiovascular Systems
Giuseppe Murdaca et al.
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Biochemistry & Molecular Biology
Scott J. Dixon et al.
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Biochemistry & Molecular Biology
E. Y. Plotnikov et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2011)
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Multidisciplinary Sciences
Pablo J. Giraudi et al.
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Pharmacology & Pharmacy
M. Ciccarelli et al.
BRITISH JOURNAL OF PHARMACOLOGY
(2008)
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Cell Biology
Christoph Ufer et al.
GENES & DEVELOPMENT
(2008)
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Cell Biology
Michele Ciccarelli et al.
CELLULAR SIGNALLING
(2007)
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Cardiac & Cardiovascular Systems
G Iaccarino et al.
