Journal
ANTIOXIDANTS
Volume 11, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/antiox11122341
Keywords
carnosol; renal fibrosis; oxidative stress; endoplasmic reticulum stress; apoptosis; necroptosis; inflammation
Ask authors/readers for more resources
Renal fibrosis, a common feature of chronic kidney disease, is a promising therapeutic target. This study found that carnosol (CS), a compound found in rosemary plants, improved renal function and reduced renal tubular injury and interstitial fibrosis in a murine model of unilateral ureteral obstruction (UUO). CS achieved this by suppressing oxidative stress, endoplasmic reticulum stress, apoptotic and necroptotic cell death, as well as cytokine production and immune cell infiltration in the kidneys.
Renal fibrosis is a common feature of chronic kidney disease and is a promising therapeutic target. However, there is still limited treatment for renal fibrosis, so the development of new anti-fibrotic agents is urgently needed. Accumulating evidence suggest that oxidative stress and endoplasmic reticulum (ER) stress play a critical role in renal fibrosis. Carnosol (CS) is a bioactive diterpene compound present in rosemary plants and has potent antioxidant and anti-inflammatory properties. In this study, we investigated the potential effects of CS on renal injury and fibrosis in a murine model of unilateral ureteral obstruction (UUO). Male C57BL/6J mice underwent sham or UUO surgery and received intraperitoneal injections of CS (50 mg/kg) daily for 8 consecutive days. CS improved renal function and ameliorated renal tubular injury and interstitial fibrosis in UUO mice. It suppressed oxidative injury by inhibiting pro-oxidant enzymes and activating antioxidant enzymes. Activation of ER stress was also attenuated by CS. In addition, CS inhibited apoptotic and necroptotic cell death in kidneys of UUO mice. Furthermore, cytokine production and immune cell infiltration were alleviated by CS. Taken together, these findings indicate that CS can attenuate renal injury and fibrosis in the UUO model.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available