Journal
BIOMOLECULES
Volume 12, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/biom12121852
Keywords
silk fibroin; silk biomaterials; wound healing; skin wounds; burn wounds; diabetic wounds
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Silk fibroin, derived from silk fibers, is a remarkable natural material for creating dressings that enhance wound healing. It has excellent biocompatibility and biodegradability, as well as anti-inflammatory and pro-angiogenic properties. Animal and clinical studies have shown that silk fibroin dressings have positive effects on various types of wounds.
The skin, acting as the outer protection of the human body, is most vulnerable to injury. Wound healing can often be impaired, leading to chronic, hard-to-heal wounds. For this reason, searching for the most effective dressings that can significantly enhance the wound healing process is necessary. In this regard, silk fibroin, a protein derived from silk fibres that has excellent properties, is noteworthy. Silk fibroin is highly biocompatible and biodegradable. It can easily make various dressings, which can be loaded with additional substances to improve healing. Dressings based on silk fibroin have anti-inflammatory, pro-angiogenic properties and significantly accelerate skin wound healing, even compared to commercially available wound dressings. Animal studies confirm the beneficial influence of silk fibroin in wound healing. Clinical research focusing on fibroin dressings is also promising. These properties make silk fibroin a remarkable natural material for creating innovative, simple, and effective dressings for skin wound healing. In this review, we summarise the application of silk fibroin biomaterials as wound dressings in full-thickness, burn, and diabetic wounds in preclinical and clinical settings.
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