4.7 Review

New Insights into lncRNAs in Aβ Cascade Hypothesis of Alzheimer's Disease

Related references

Note: Only part of the references are listed.
Article Genetics & Heredity

lncRNA XIST induces Aβ accumulation and neuroinflammation by the epigenetic repression of NEP in Alzheimer's disease

Xi-Wu Yan et al.

Summary: This study found that lncRNA XIST induces A beta accumulation and neuroinflammation in Alzheimer's disease (AD) through epigenetic repression of NEP.

JOURNAL OF NEUROGENETICS (2022)

Article Genetics & Heredity

Epigenetic axis of SNHG19/miR-137/TNFAIP1 modulates amyloid beta peptide 25-35-induced SH-SY5Y cytotoxicity

Yipei Li et al.

Summary: This study suggests that the epigenetic axis of SNHG19/hsa-miR-137/TNFAIP1 may functionally regulate A beta(25-35)-induced SH-SY5Y cytotoxicity, making it a potential molecular target for Alzheimer's disease treatment.

EPIGENOMICS (2022)

Article Geriatrics & Gerontology

LncRNA BDNF-AS as ceRNA regulates the miR-9-5p/BACE1 pathway affecting neurotoxicity in Alzheimer's disease

Yuting Ding et al.

Summary: This study found that BDNF-AS is upregulated in patients with AD and may be associated with cognitive status. BDNF-AS can promote neurotoxicity by competitively binding to miR-9-5p to promote the expression of BACE1, thereby promoting amyloid deposition. High expression of BDNF-AS aggravates cognitive impairment in AD mice.

ARCHIVES OF GERONTOLOGY AND GERIATRICS (2022)

Article Cell Biology

TARBP2-stablized SNHG7 regulates blood-brain barrier permeability by acting as a competing endogenous RNA to miR-17-5p/NFATC3 in Aβ-microenvironment

Hao Ning et al.

Summary: Breakdown of the blood-brain barrier (BBB) is an important pathological marker in the development of Alzheimer's disease. Beta-amyloid deposition disrupts tight junction proteins formed by endothelial cells, leading to increased BBB permeability. Through regulation of various genes and molecules, the TARBP2/SNHG7/miR-17-5p/NFATC3 pathway may provide insights into the changes in the BBB during the progression of Alzheimer's disease.

CELL DEATH & DISEASE (2022)

Article Medicine, Research & Experimental

Long non-coding RNA MALAT1 protects against Aβ1-42 induced toxicity by regulating the expression of receptor tyrosine kinase EPHA2 via quenching miR-200a/26a/26b in Alzheimer's disease

Kaushik Chanda et al.

Summary: This article explores the role of lncRNAs in Alzheimer's disease and identifies MALAT1 as a regulator of miR-200a/26a/26b, which can protect against the disease by regulating EPHA2. This novel regulatory mechanism promises to become a significant strategy in controlling Alzheimer's disease.

LIFE SCIENCES (2022)

Article Biochemistry & Molecular Biology

If amyloid drives Alzheimer disease, why have anti-amyloid therapies not yet slowed cognitive decline?

Christian Haass et al.

Summary: Strong genetic evidence supports an imbalance between production and clearance of amyloid beta-protein (Aβ) in people with Alzheimer disease (AD). Microglia, potentially involved in alternative mechanisms, are integral to the amyloid cascade. Fluid biomarkers and brain imaging indicate that Aβ accumulation occurs at the beginning of molecular and clinical changes in the disease. Despite this, clinical trials of anti-amyloid therapies have not shown clear benefits for patients with AD. Key questions about whether anti-amyloid therapies can effectively decrease Aβ in the human brain and if it is already too late are urgently being addressed in AD research.

PLOS BIOLOGY (2022)

Article Neurosciences

LncRNA RPPH1 attenuates Aβ25-35-induced endoplasmic reticulum stress and apoptosis in SH-SY5Y cells via miR-326/PKM2

Ran Gu et al.

Summary: The study demonstrated that lncRNA RPPH1 can attenuate A beta(25-35)-induced ERS and apoptosis in SH-SY5Y cells by regulating the miR-326/PKM2 axis, improving cell viability. This provides therapeutic options for AD patients.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2021)

Review Cell Biology

The neurobiology of non-coding RNAs and Alzheimer's disease pathogenesis: Pathways, mechanisms and translational opportunities

Elisabetta Lauretti et al.

Summary: Non-protein-coding RNAs have been found to play significant roles in neurodegenerative disorders such as Alzheimer's disease, affecting gene expression, amyloid-beta production, and other key mechanisms underlying disease pathology.

AGEING RESEARCH REVIEWS (2021)

Review Biochemistry & Molecular Biology

The tandem repeat modules of Xist lncRNA : a swiss army knife for the control of X-chromosome inactivation

Ana Claudia Raposo et al.

Summary: Xist is a long non-coding RNA essential for X-chromosome inactivation in female placental mammals, with functional domains interacting with RNA binding proteins and folding into distinct RNA structures to execute specific tasks during the inactivation process. Differences exist regarding functional specialization of the tandem repeats between humans and mice.

BIOCHEMICAL SOCIETY TRANSACTIONS (2021)

Article Cell Biology

Silenced lncRNA H19 and up-regulated microRNA-129 accelerates viability and restrains apoptosis of PC12 cells induced by Aβ25-35 in a cellular model of Alzheimer's disease

Yan-Yun Zhang et al.

Summary: Long non-coding RNA H19 and microRNA-129 are key players in the pathogenesis of Alzheimer's disease, regulating cell viability and apoptosis in response to A beta(25-35) stimulation. Modulation of these molecules may have therapeutic potential for Alzheimer's disease treatment.

CELL CYCLE (2021)

Article Geriatrics & Gerontology

Deregulated lncRNA MAGI2-AS3 in Alzheimer's disease attenuates amyloid-β induced neurotoxicity and neuroinflammation by sponging miR-374b-5p

Jingjing Zhang et al.

Summary: This study explored the regulatory effects of MAGI2-AS3 and miR-374b-5p on A beta-induced neurotoxicity and neuroinflammation in Alzheimer's disease. The findings suggest that the MAGI2-AS3/miR-374b-5p axis may serve as potential biomarkers and therapeutic targets for AD, as it can attenuate neuronal injury and inflammation. The expression levels of MAGI2-AS3 and miR-374b-5p were negatively correlated in AD patients and correlated with disease severity, highlighting their potential importance in AD pathogenesis.

EXPERIMENTAL GERONTOLOGY (2021)

Review Medicine, General & Internal

Alzheimer's disease

Philip Scheltens et al.

Summary: Alzheimer's disease is projected to see a significant increase in prevalence in the future, with genetics playing a key role. Novel biomarkers and lifestyle-based prevention trials show promising therapeutic potential. Promising pharmacological treatments are advancing in clinical trials, targeting amyloid beta, tau, and inflammation.

LANCET (2021)

Article Neurosciences

LncRNA BACE1-AS Promotes Autophagy-Mediated Neuronal Damage Through The miR-214-3p/ATG5 Signalling Axis In Alzheimer's Disease

Yuan Zhou et al.

Summary: Alzheimer's disease (AD) is characterized by progressive memory loss and cognitive dysfunction, with long non-coding RNAs (lncRNAs) showing promise as biomarkers and therapeutic targets. The study found that silencing of lncRNA BACE1-AS alleviated neuronal injury by regulating autophagy through the miR-214-3p/ATG5 signaling axis in AD. These findings suggest a potential therapeutic target for AD treatment.

NEUROSCIENCE (2021)

Article Multidisciplinary Sciences

Receptor tyrosine kinase ROR1 ameliorates Aβ1-42 induced cytoskeletal instability and is regulated by the miR146a-NEAT1 nexus in Alzheimer's disease

Kaushik Chanda et al.

Summary: The study found that in an Alzheimer's disease cell model, the expression of ROR1 significantly decreased, but overexpression of ROR1 can protect cytoskeletal protein degradation, alter actin dynamics, and promote neuritogenesis. MiRNAs hsa-miR-146a and 34a were upregulated in the cell model, and their overexpression can repress ROR1.

SCIENTIFIC REPORTS (2021)

Review Medicine, Research & Experimental

Novel insights for lncRNA MAGI2-AS3 in solid tumors

Chen Xue et al.

Summary: MAGI2-AS3, a long non-coding RNA, is aberrantly expressed in solid tumors and has been shown to be correlated with patient clinical characteristics. It regulates multiple biological processes through target-gene regulation, making it a potential diagnostic biomarker and therapeutic target against solid tumors. Understanding the properties of MAGI2-AS3 may provide new insights into the diagnoses and treatments of solid tumors.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Biochemical Research Methods

Genome-wide analysis of lncRNA stability in human

Kaiwen Shi et al.

Summary: Transcript stability is important for many biological processes. Little is known about the features related to human lncRNA stability. Our study found a nonlinear relationship between the half-lives of lncRNAs (mRNAs) and related factors through quantitative analysis. Further research is needed to develop an accurate quantitative prediction model for the half-lives of lncRNAs (mRNAs).

PLOS COMPUTATIONAL BIOLOGY (2021)

Article Medicine, Research & Experimental

Roles of lncRNA MAGI2-AS3 in human cancers

Liu Kai-xin et al.

Summary: Long noncoding RNAs (lncRNAs) play crucial roles in cancer, with MAGI2-AS3 being a widely expressed lncRNA associated with cancer development and prognosis. Dysregulation of MAGI2-AS3 can affect cancer cell behaviors and treatment responses, making it a potential biomarker and therapeutic target for cancer.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Biochemistry & Molecular Biology

SRY-Box 21 Antisense RNA 1 Knockdown Diminishes Amyloid Beta25-35-Induced Neuronal Damage by miR-132/PI3K/AKT Pathway

Fengming Gu et al.

Summary: The study showed that knockdown of SOX21-AS1 alleviated Aβ(25-35)-induced neuronal cell damage by promoting the miR-132/PI3K/AKT pathway.

NEUROCHEMICAL RESEARCH (2021)

Review Cell Biology

Biological Function of Long Non-coding RNA (LncRNA) Xist

Wenlun Wang et al.

Summary: Long non-coding RNAs (lncRNAs) play important roles in cellular functions by regulating target gene expression levels through epigenomic, transcriptional, and post-transcriptional approaches. Among them, long non-coding RNA X-inactive specific transcript (lncRNA Xist) acts as a crucial regulator in X chromosome inactivation and various disease processes.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

TNFAIP1 Is Upregulated in APP/PS1 Mice and Promotes Apoptosis in SH-SY5Y Cells by Binding to RhoB

Ye Xiao et al.

Summary: This study reveals that TNFAIP1 is overexpressed in the neurons of AD mice, and it plays a role in Aβ-induced apoptosis through the RhoB signaling pathway, leading to increased ROS production and decreased mitochondrial membrane potential.

JOURNAL OF MOLECULAR NEUROSCIENCE (2021)

Article Neurosciences

LncRNA Rpph1 protects amyloid-β induced neuronal injury in SK-N-SH cells via miR-122/Wnt1 axis

Ran Gu et al.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2020)

Article Endocrinology & Metabolism

Inhibition of NFAT Signaling Restores Microvascular Endothelial Function in Diabetic Mice

Eliana Garcia-Vaz et al.

DIABETES (2020)

Review Medicine, Research & Experimental

SNHG7: A novel vital oncogenic lncRNA in human cancers

Yong Zhou et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Article Biochemistry & Molecular Biology

Distinct Processing of lncRNAs Contributes to Non-conserved Functions in Stem Cells

Chun-Jie Guo et al.

Review Clinical Neurology

LncRNA Xist, X-chromosome Instability and Alzheimer's Disease

Kaushik Chanda et al.

CURRENT ALZHEIMER RESEARCH (2020)

Review Medicine, Research & Experimental

The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease

Meysam Amidfar et al.

LIFE SCIENCES (2020)

Article Cell Biology

Neprilysin expression and functions in development, ageing and disease

N. N. Nalivaeva et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2020)

Article Neurosciences

Antisense Oligonucleotide Therapies for Neurodegenerative Diseases

C. Frank Bennett et al.

Annual Review of Neuroscience (2019)

Article Biochemistry & Molecular Biology

NEAT1 regulates neuroglial cell mediating Aβ clearance via the epigenetic regulation of endocytosis-related genes expression

Ziqiang Wang et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

Article Biochemistry & Molecular Biology

BACE1-AS prevents BACE1 mRNA degradation through the sequestration of BACE1-targeting miRNAs

Tao Zeng et al.

JOURNAL OF CHEMICAL NEUROANATOMY (2019)

Article Biochemistry & Molecular Biology

Knockdown of lncRNA SNHG1 attenuated Aβ25-35 -inudced neuronal injury via regulating KREMEN1 by acting as a ceRNA of miR-137 in neuronal cells

Hui Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Review Genetics & Heredity

Long Non-coding RNA in Neuronal Development and Neurological Disorders

Ling Li et al.

FRONTIERS IN GENETICS (2019)

Article Cell Biology

Emerging roles of long non-coding RNAs in the pathogenesis of Alzheimer's disease

Francesca Cortini et al.

AGEING RESEARCH REVIEWS (2019)

Review Biochemistry & Molecular Biology

Functional Classification and Experimental Dissection of Long Noncoding RNAs

Florian Kopp et al.

Article Biochemistry & Molecular Biology

Long Noncoding RNA EBF3-AS Promotes Neuron Apoptosis in Alzheimer's Disease

Cheng Gu et al.

DNA AND CELL BIOLOGY (2018)

Review Biochemistry & Molecular Biology

The Role of Long Non-Coding RNAs in Hepatocarcinogenesis

Manuela Lanzafame et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biochemistry & Molecular Biology

Multiple Layers of CDK5R1 Regulation in Alzheimer's Disease Implicate Long Non-Coding RNAs

Marco Spreafico et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Medicine, Research & Experimental

Suppression of lncRNA-ATB prevents amyloid-β-induced neurotoxicity in PC12 cells via regulating miR-200/ZNF217 axis

Jindong Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Clinical Neurology

Somatic variants in autosomal dominant genes are a rare cause of sporadic Alzheimer's disease

Gael Nicolas et al.

ALZHEIMERS & DEMENTIA (2018)

Article Biotechnology & Applied Microbiology

Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci

Paulo P. Amaral et al.

GENOME BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Integrative classification of human coding and noncoding genes through RNA metabolism profiles

Neelanjan Multherjee et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Integrative classification of human coding and noncoding genes through RNA metabolism profiles

Neelanjan Multherjee et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)

Review Cell Biology

LncRNA-ATB: An indispensable cancer-related long noncoding RNA

Jinglin Li et al.

CELL PROLIFERATION (2017)

Review Chemistry, Multidisciplinary

Amyloid beta: structure, biology and structure-based therapeutic development

Guo-fang Chen et al.

ACTA PHARMACOLOGICA SINICA (2017)

Review Cardiac & Cardiovascular Systems

Pharmacogenomics of angiotensin receptor/neprilysin inhibitor and its long-term side effects

Chayakrit Krittanawong et al.

CARDIOVASCULAR THERAPEUTICS (2017)

Review Neurosciences

Alzheimer's Disease Mechanisms and Emerging Roads to Novel Therapeutics

Carlo Sala Frigerio et al.

ANNUAL REVIEW OF NEUROSCIENCE, VOL 39 (2016)

Correction Medicine, Research & Experimental

Long non-coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling (vol 8, pg 346, 2016)

Jin Yao et al.

EMBO MOLECULAR MEDICINE (2016)

Article Biochemistry & Molecular Biology

RNA Helicase Associated with AU-rich Element (RHAU/DHX36) Interacts with the 3′-Tail of the Long Non-coding RNA BC200 (BCYRN1)

Evan P. Booy et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Genetics & Heredity

The landscape of long noncoding RNAs in the human transcriptome

Matthew K. Iyer et al.

NATURE GENETICS (2015)

Article Geriatrics & Gerontology

Identification of Alzheimer's disease-associated long noncoding RNAs

Xiaolin Zhou et al.

NEUROBIOLOGY OF AGING (2015)

Review Genetics & Heredity

The Landscape of long noncoding RNA classification

Georges St Laurent et al.

TRENDS IN GENETICS (2015)

Article Biochemistry & Molecular Biology

Nuclear Translocation Uncovers the Amyloid Peptide Aβ42 as a Regulator of Gene Transcription

Christian Barucker et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Kruppel-like Factor 8 Ameliorates Alzheimer's Disease by Activating β-Catenin

Ran Yi et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2014)

Article Biochemistry & Molecular Biology

LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint

Nadya Dimitrova et al.

MOLECULAR CELL (2014)

Review Biochemistry & Molecular Biology

Dysfunctional Wnt/β-catenin signaling contributes to blood-brain barrier breakdown in Alzheimer's disease

Lumei Liu et al.

NEUROCHEMISTRY INTERNATIONAL (2014)

Article Neurosciences

Neuronal Clearance of Amyloid-β by Endocytic Receptor LRP1

Takahisa Kanekiyo et al.

JOURNAL OF NEUROSCIENCE (2013)

Review Geriatrics & Gerontology

Neprilysin and Aβ clearance: impact of the APP intracellular domain in NEP regulation and implications in Alzheimer's disease

Marcus O. W. Grimm et al.

FRONTIERS IN AGING NEUROSCIENCE (2013)

Article Biochemistry & Molecular Biology

NDM29, a RNA polymerase III-dependent non coding RNA, promotes amyloidogenic processing of APP and amyloid β secretion

Sara Massone et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)

Review Biochemistry & Molecular Biology

Mechanisms of Amyloid-β Peptide Clearance: Potential Therapeutic Targets for Alzheimer's Disease

Sang-Sun Yoon et al.

BIOMOLECULES & THERAPEUTICS (2012)

Article Biochemistry & Molecular Biology

Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease

Vanessa Schmidt et al.

EMBO JOURNAL (2012)

Article Cell Biology

A triple helix stabilizes the 3′ ends of long noncoding RNAs that lack poly(A) tails

Jeremy E. Wilusz et al.

GENES & DEVELOPMENT (2012)

Article Biochemistry & Molecular Biology

Genome-wide analysis of long noncoding RNA stability

Michael B. Clark et al.

GENOME RESEARCH (2012)

Article Multidisciplinary Sciences

Landscape of transcription in human cells

Sarah Djebali et al.

NATURE (2012)

Article Multidisciplinary Sciences

An integrated encyclopedia of DNA elements in the human genome

Ian Dunham et al.

NATURE (2012)

Article Biotechnology & Applied Microbiology

Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation

Farzaneh Modarresi et al.

NATURE BIOTECHNOLOGY (2012)

Article Multidisciplinary Sciences

Formation of triple-helical structures by the 3′-end sequences of MALAT1 and MENβ noncoding RNAs

Jessica A. Brown et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Medicine, Research & Experimental

Trafficking and Proteolytic Processing of APP

Christian Haass et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Review Pharmacology & Pharmacy

Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders

Anita E. Autry et al.

PHARMACOLOGICAL REVIEWS (2012)

Review Neurosciences

Amyloid Precursor Protein Processing and Alzheimer's Disease

Richard J. O'Brien et al.

ANNUAL REVIEW OF NEUROSCIENCE, VOL 34 (2011)

Article Pharmacology & Pharmacy

The Neurotrophins and Their Role in Alzheimers Disease

Shelley J. Allen et al.

Current Neuropharmacology (2011)

Article Biochemistry & Molecular Biology

Acquisition of neuron-like electrophysiological properties in neuroblastoma cells by controlled expression of NDM29 ncRNA

Paola Gavazzo et al.

JOURNAL OF NEUROCHEMISTRY (2011)

Review Biotechnology & Applied Microbiology

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

Eric Karran et al.

NATURE REVIEWS DRUG DISCOVERY (2011)

Review Medicine, General & Internal

Diagnosis and biomarkers of predementia in Alzheimer's disease

Orestes V. Forlenza et al.

BMC MEDICINE (2010)

Article Biochemistry & Molecular Biology

A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression

Delphine Bernard et al.

EMBO JOURNAL (2010)

Article Psychiatry

Clinical and biological predictors of Alzheimer's disease in patients with amnestic mild cognitive impairment

Orestes V. Forlenza et al.

REVISTA BRASILEIRA DE PSIQUIATRIA (2010)

Editorial Material Biotechnology & Applied Microbiology

Evidence for natural antisense transcript-mediated inhibition of microRNA function

Mohammad Ali Faghihi et al.

GENOME BIOLOGY (2010)

Review Biochemistry & Molecular Biology

Evolution and Functions of Long Noncoding RNAs

Chris P. Ponting et al.

Article Neurosciences

Microglia Mediate the Clearance of Soluble Aβ through Fluid Phase Macropinocytosis

Shweta Mandrekar et al.

JOURNAL OF NEUROSCIENCE (2009)

Article Psychiatry

Decreased Serum Brain-Derived Neurotrophic Factor Levels in Elderly Korean with Dementia

Jung Goo Lee et al.

PSYCHIATRY INVESTIGATION (2009)

Review Neurosciences

New insights into brain BDNF function in normal aging and Alzheimer disease

Lucia Tapia-Arancibia et al.

BRAIN RESEARCH REVIEWS (2008)

Article Behavioral Sciences

BDNF is a novel marker of cognitive function in ageing women: The DR's EXTRA Study

Pirjo Komulainen et al.

NEUROBIOLOGY OF LEARNING AND MEMORY (2008)

Review Genetics & Heredity

The expanding RNA polymerase III transcriptome

Giorgio Dieci et al.

TRENDS IN GENETICS (2007)

Article Biochemistry & Molecular Biology

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1

Vanessa Schmidt et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Multidisciplinary Sciences

Dendritic BC200 RNA in aging and in Alzheimer's disease

El Mus et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Multidisciplinary Sciences

RNA maps reveal new RNA classes and a possible function for pervasive transcription

Philipp Kapranov et al.

SCIENCE (2007)

Article Clinical Neurology

Stage-dependent BDNF serum concentrations in Alzheimer's disease

C. Laske et al.

JOURNAL OF NEURAL TRANSMISSION (2006)

Article Cell Biology

The H19 gene: regulation and function of a non-coding RNA

A. Gabory et al.

CYTOGENETIC AND GENOME RESEARCH (2006)

Article Biotechnology & Applied Microbiology

Positional and functional mapping of a neuroblastoma differentiation gene on chromosome 11 -: art. no. 97

K De Preter et al.

BMC GENOMICS (2005)

Article Genetics & Heredity

Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's disease

QR Liu et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2005)

Review Biochemistry & Molecular Biology

Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective

RE Tanzi et al.

Article Clinical Neurology

Loss of apolipoprotein E receptor LR11 in Alzheimer disease

CR Scherzer et al.

ARCHIVES OF NEUROLOGY (2004)

Letter Biochemistry & Molecular Biology

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

LB Yang et al.

NATURE MEDICINE (2003)

Article Clinical Neurology

β-secretase protein and activity are increased in the neocortex in Alzheimer disease

H Fukumoto et al.

ARCHIVES OF NEUROLOGY (2002)

Review Neurosciences

Trk receptors: mediators of neurotrophin action

A Patapoutian et al.

CURRENT OPINION IN NEUROBIOLOGY (2001)

Review Neurosciences

Neurotrophins as synaptic modulators

MM Poo

NATURE REVIEWS NEUROSCIENCE (2001)

Review Neurosciences

Neurotrophins: Roles in neuronal development and function

EJ Huang et al.

ANNUAL REVIEW OF NEUROSCIENCE (2001)

Review Neurosciences

Neurotrophic factors in Alzheimer's and Parkinson's disease brain

GJ Siegel et al.

BRAIN RESEARCH REVIEWS (2000)