4.7 Review

The Pathophysiological Significance of Mitochondrial Ejection from Cells

Related references

Note: Only part of the references are listed.
Review Cardiac & Cardiovascular Systems

Macrophages, Metabolism and Heterophagy in the Heart

Jose A. Nicolas-Avila et al.

Summary: This article provides an immunologist's perspective on how the heart deals with the challenge of maintaining organelle fitness and cell function due to its high metabolic rate. The heart incorporates macrophages into the myocardium and utilizes heterophagy, a process where macrophages capture dysfunctional mitochondria ejected by cardiomyocytes. This partnership is essential for proteostasis and metabolic fitness of the heart.

CIRCULATION RESEARCH (2022)

Article Nanoscience & Nanotechnology

Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells

Tanmoy Saha et al.

Summary: Cancer cells hijack mitochondria from immune cells via physical nanotubes, empowering themselves while depleting the immune cells. Inhibiting the nanotube assembly machinery can prevent mitochondrial transfer and potentially serve as an immunotherapy approach.

NATURE NANOTECHNOLOGY (2022)

Article Neurosciences

Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain

Michiel van der Vlist et al.

Summary: The resolution of inflammatory pain is actively controlled by macrophages through the transfer of mitochondria to sensory neurons. This process requires the expression of CD200R on macrophages and the non-canonical CD200R ligand iSec1 on sensory neurons.

NEURON (2022)

Article Cell Biology

Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue

Marco Rosina et al.

Summary: Recent findings show that mitochondria can be transferred between cells to control metabolic homeostasis. This study reveals that thermogenically stressed brown adipocytes release extracellular vesicles (EVs) containing damaged mitochondrial parts to avoid failure of the thermogenic program. The efficient removal of these EVs by tissue-resident macrophages is crucial for preserving the function of brown adipose tissue (BAT) and its response to cold exposure.

CELL METABOLISM (2022)

Article Geriatrics & Gerontology

Neurons Release Injured Mitochondria as Help-Me Signaling After Ischemic Stroke

Li Gao et al.

Summary: Mitochondrial dysfunction is a major cause of neuronal death after stroke, and intercellular mitochondrial transfer shows promise as a potential therapeutic approach. Neurons release more mitochondria when exposed to challenges like acidosis, hydrogen peroxide, NMDA, or glutamate, which are then engulfed by adjacent astrocytes. This transfer may serve as a signaling mechanism to mediate the interaction between neurons and astrocytes.

FRONTIERS IN AGING NEUROSCIENCE (2022)

Review Cell & Tissue Engineering

Mesenchymal Stromal Cell Mitochondrial Transfer as a Cell Rescue Strategy in Regenerative Medicine: A Review of Evidence in Preclinical Models

Yu Ling Tan et al.

Summary: Mesenchymal stromal cells (MSC) have the potential to treat damaged cells through mitochondrial transfer. However, the mechanisms of mitochondrial transfer and factors contributing to mitochondrial bioenergetics recovery need further investigation.

STEM CELLS TRANSLATIONAL MEDICINE (2022)

Article Medicine, Research & Experimental

AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages

Liangjun Xia et al.

Summary: AdMSC-Exos effectively donate mitochondrial components to improve macrophage mitochondrial integrity and oxidative phosphorylation, leading to the restoration of metabolic and immune homeostasis in airway macrophages and alleviating lung inflammatory pathology.

THERANOSTICS (2022)

Article Endocrinology & Metabolism

Mitochondrial transfer from mesenchymal stem cells improves neuronal metabolism after oxidant injury in vitro: The role of Miro1

Nancy Tseng et al.

Summary: This study examines the role of mitochondrial transfer from MSC to neurons in neuronal preservation after oxidant injury. The transfer of mitochondria led to increased neuronal survival and improved metabolism. Regulation of the Miro1 gene expression can affect the metabolic benefit of mitochondrial transfer.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2021)

Article Oncology

Mitochondria-Rich Extracellular Vesicles Rescue Patient-Specific Cardiomyocytes From Doxorubicin Injury Insights Into the SENECA Trial

Connor G. O'Brien et al.

Summary: This study evaluated the efficacy and mechanisms of MSCs in treating DOX injury using patient-specific iCMs. Results showed that L-EVs derived from MSCs mediated mitochondrial transfer to mitigate DOX injury in patient-specific iCMs.

JACC: CARDIOONCOLOGY (2021)

Review Cell Biology

Quality control of the mitochondrial proteome

Jiyao Song et al.

Summary: Mitochondria contain a diverse array of proteins from two genomes and require synchronized gene expression for proper function. The mitochondrial proteome is highly adaptable and regulated by quality control systems to ensure cellular adaptation and functionality. Defects in mitochondrial protein quality control mechanisms can lead to proteotoxic insults and cell death, highlighting the critical importance of maintaining protein homeostasis in mitochondria.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Cell Biology

Alternative mitochondrial quality control mediated by extracellular release

Chi-Jing Choong et al.

Summary: Mitochondrial quality control is not only maintained through mitophagy, but can also be achieved by the release of mitochondria into the extracellular space. Factors such as mitochondrial damage can lead to extracellular mitochondrial release, which can be suppressed by overexpression of PRKN.

AUTOPHAGY (2021)

Article Chemistry, Multidisciplinary

Microvesicles transfer mitochondria and increase mitochondrial function in brain endothelial cells

Anisha D'Souza et al.

Summary: It was shown for the first time that microvesicles derived from human brain endothelial cells can transfer polarized mitochondria to recipient cells and increase ATP levels. The study also revealed a high association to glycolysis-related processes and demonstrated the selective transfer of mitochondria to increase endothelial cell survival under ischemic conditions.

JOURNAL OF CONTROLLED RELEASE (2021)

Article Cardiac & Cardiovascular Systems

Mitochondria-Rich Extracellular Vesicles From Autologous Stem Cell-Derived Cardiomyocytes Restore Energetics of Ischemic Myocardiums

Gentaro Ikeda et al.

Summary: This study demonstrated that extracellular vesicle-mediated transfer of autologous mitochondria can enhance cardiac function by restoring myocardial bioenergetics. The therapy shows potential as a precision therapeutic for mitochondria-related diseases such as heart failure.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

Review Biochemistry & Molecular Biology

Mitochondrial Transfer in Cancer: A Comprehensive Review

Luca X. Zampieri et al.

Summary: Mitochondria play crucial roles in cancer cells, participating in energy production, controlling cell death, and influencing cancer cell activities like migration, invasion, metastasis, and resistance to treatments. Understanding mitochondrial transfers between cells may lead to new anticancer approaches targeting cancer cell functions and mitochondrial elimination.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs

Kiran Todkar et al.

Summary: Mitochondrial content in extracellular vesicles (EVs) can exacerbate inflammation, while its role in non-inflammatory conditions remains unclear. The research demonstrates that mitochondria-derived vesicles target material to EVs, while Parkinson's disease-related protein Parkin directs damaged mitochondrial content to lysosomes, shedding light on mitochondria-driven immune responses.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Sparsely methylated mitochondrial cell free DNA released from cardiomyocytes contributes to systemic inflammatory response accompanied by atrial fibrillation

Masahiro Yamazoe et al.

Summary: Studies have shown that patients with atrial fibrillation (AF) have higher levels of cfDNA in their blood, especially mt-cfDNA. cfDNA and mt-cfDNA can promote the expression of IL-1 beta and IL-6 in macrophages through TLR9.

SCIENTIFIC REPORTS (2021)

Article Biochemistry & Molecular Biology

Neural stem cells traffic functional mitochondria via extracellular vesicles

Luca Peruzzotti-Jametti et al.

Summary: Neural stem cell transplantation induces recovery in animal models of central nervous system diseases through multiple mechanisms, including the horizontal exchange of therapeutic cargoes via extracellular vesicles. The study demonstrates that neural stem cells release and transfer functional mitochondria through EVs to restore mitochondrial function in target cells.

PLOS BIOLOGY (2021)

Article Cell Biology

Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes

Clair Crewe et al.

Summary: Adipocytes under energetic stress release sEVs containing damaged mitochondrial particles, which enter circulation and trigger antioxidant signaling in cardiomyocytes, protecting them from oxidative stress. This functional mitochondrial transfer between tissues provides potent cardio-protection against stresses induced by obesity.

CELL METABOLISM (2021)

Article Biochemistry & Molecular Biology

Mitocytosis, a migrasome-mediated mitochondrial quality-control process

Haifeng Jiao et al.

Summary: Mitocytosis is a migrasome-mediated mitochondrial quality-control process that helps maintain mitochondrial quality in migrating cells. The process involves positioning damaged mitochondria at the cell periphery, which avoids binding to inward motor proteins. Enhanced mitocytosis protects cells from mitochondrial stressor-induced loss of mitochondrial membrane potential and mitochondrial respiration, while blocking mitocytosis causes loss of these functions under normal conditions. Physiologically, mitocytosis is required for maintaining mitochondrial membrane potential and viability in neutrophils in vivo.
Review Biochemistry & Molecular Biology

Intercellular mitochondrial transfer as a means of tissue revitalization

Delin Liu et al.

Summary: Mitochondria, crucial for cell metabolism and tissue survival, undergo morphological changes and can be transferred intercellularly. The phenomenon of mitochondrial transfer plays a key role in tissue homeostasis, damaged tissue repair, tumor progression, and immunoregulation, functioning under both physiological and pathological conditions. Various mechanisms contributing to this process, such as trigger factors and transfer routes, are summarized in order to explore potential therapeutic strategies for rescuing tissue damage and inhibiting tumor progression through mitochondria-targeted applications.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Article Neurosciences

Astrocytes rescue neuronal health after cisplatin treatment through mitochondrial transfer

Krystal English et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart

Jose A. Nicolas-Avila et al.

Article Cell & Tissue Engineering

Mesenchymal stem cell repression of Th17 cells is triggered by mitochondrial transfer

Patricia Luz-Crawford et al.

STEM CELL RESEARCH & THERAPY (2019)

Article Multidisciplinary Sciences

Endoplasmic reticulum mediates mitochondrial transfer within the osteocyte dendritic network

Junjie Gao et al.

SCIENCE ADVANCES (2019)

Review Cell Biology

Mitochondrial quality control in cardiac cells: Mechanisms and role in cardiac cell injury and disease

Farzaneh G. Tahrir et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Review Physiology

The Role of Autophagy in the Heart

Sebastiano Sciarretta et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 80 (2018)

Review Cell Biology

Shedding light on the cell biology of extracellular vesicles

Guillaume van Niel et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cells

Kenneth P. Hough et al.

REDOX BIOLOGY (2018)

Review Cardiac & Cardiovascular Systems

Mitochondrial quality control mechanisms as molecular targets in cardiac ageing

Anna Picca et al.

NATURE REVIEWS CARDIOLOGY (2018)

Article Cell & Tissue Engineering

Connexin 43-Mediated Mitochondrial Transfer of iPSC-MSCs Alleviates Asthma Inflammation

Yin Yao et al.

STEM CELL REPORTS (2018)

Article Multidisciplinary Sciences

C-elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress

Ilija Melentijevic et al.

NATURE (2017)

Article Biochemistry & Molecular Biology

Control of mitochondrial biogenesis and function by the ubiquitin - proteasome system

Piotr Bragoszewski et al.

OPEN BIOLOGY (2017)

Article Critical Care Medicine

Mesenchymal Stromal Cells Modulate Macrophages in Clinically Relevant Lung Injury Models by Extracellular Vesicle Mitochondrial Transfer

Thomas J. Morrison et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)

Review Immunology

Mitochondrial DNA in innate immune responses and inflammatory pathology

A. Phillip West et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Article Multidisciplinary Sciences

Transfer of mitochondria from astrocytes to neurons after stroke

Kazuhide Hayakawa et al.

NATURE (2016)

Review Biochemistry & Molecular Biology

Mitochondrial dynamics and mitochondrial quality control

Hong-Min Ni et al.

REDOX BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Mitochondrial Transfer of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells to Airway Epithelial Cells Attenuates Cigarette Smoke-Induced Damage

Xiang Li et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2014)

Review Biochemistry & Molecular Biology

A new pathway for mitochondrial quality control: mitochondrial-derived vesicles

Ayumu Sugiura et al.

EMBO JOURNAL (2014)

Review Multidisciplinary Sciences

Mitochondrial form and function

Jonathan R. Friedman et al.

NATURE (2014)

Article Multidisciplinary Sciences

Transcellular degradation of axonal mitochondria

Chung-ha O. Davis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Biochemistry & Molecular Biology

Mitochondria: In Sickness and in Health

Jodi Nunnari et al.

Article Biochemistry & Molecular Biology

Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury

Mohammad Naimul Islam et al.

NATURE MEDICINE (2012)

Article Cell Biology

Tunneling-nanotube direction determination in neurons and astrocytes

X. Sun et al.

CELL DEATH & DISEASE (2012)

Article Cardiac & Cardiovascular Systems

Long-distance intercellular connectivity between cardiomyocytes and cardiofibroblasts mediated by membrane nanotubes

Kangmin He et al.

CARDIOVASCULAR RESEARCH (2011)

Article Biochemistry & Molecular Biology

Tunneling-nanotube development in astrocytes depends on p53 activation

Y. Wang et al.

CELL DEATH AND DIFFERENTIATION (2011)

Article Cell Biology

Cell-to-cell cross-talk between mesenchymal stem cells and cardiomyocytes in co-culture

E. Y. Plotnikov et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2008)

Article Multidisciplinary Sciences

Mitochondrial transfer between cells can rescue aerobic respiration

JL Spees et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Multidisciplinary Sciences

Nanotubular highways for intercellular organelle transport

A Rustom et al.

SCIENCE (2004)

Article Biochemistry & Molecular Biology

Shaping the mitochondrial proteome

T Gabaldón et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2004)