Stimuli-responsive injectable chitosan-based hydrogels for controlled drug delivery systems

In the last decade, injectable hydrogels have attracted a lot of attention due to their excellent functional properties in the field of drug delivery for precise, non-invasive and focused tissue locations. Therefore, designing drug delivery systems (DDS) responsive to hydrogel stimuli to release a drug to an external stimulus with various advantages, can be very challenging. Due to their biocompatibility, mucosal adhesion, and hemostatic activity, chitosan (Chitosan)-based hydrogels offer a lot of potential for tissue engineering and drug delivery. It can be difficult to manage the structure of these stimuli-responsive CS hydrogels or they may require additional crosslinking agents, such as hydrogels with dual pH and thermo-responsiveness. Therefore, it is crucial to create these hydrogels for medicinal applications.

Automated summary

Injectable hydrogels have gained significant attention in the past decade for their functional properties in drug delivery, particularly in precise, non-invasive, and targeted tissue locations. The development of drug delivery systems that are responsive to hydrogel stimuli to release drugs under various external stimuli is a challenging task. Chitosan-based hydrogels, known for their biocompatibility, mucosal adhesion, and hemostatic activity, hold great potential for tissue engineering and drug delivery. However, managing the structure of stimuli-responsive chitosan hydrogels or incorporating additional crosslinking agents, such as those with dual pH and thermo-responsiveness, can be difficult. Therefore, it is crucial to create these hydrogels for medicinal applications.