Journal
CELL METABOLISM
Volume 21, Issue 5, Pages 663-665Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2015.04.021
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The link between smoking and insulin resistance, despite weight loss, is well established; however, the underlying mechanisms remain elusive. A recent article published in Nature Medicine by Wu et al. (2015) reports that nicotine, the main bioactive component of tobacco smoke, activates AMPK alpha 2 in adipocytes, leading to impaired insulin sensitivity.
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