Journal
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2022.905516
Keywords
exosomes; stem cell-derived exosomes; stem cell; retinal degeneration; cell-free therapy
Funding
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province
- [82000924]
- [2020JJ4793]
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With the aging population growing, the number of patients with retinal degeneration causing vision loss is also increasing. Stem cell therapies offer hope for regeneration and repair of damaged retinal tissue, while exosomes derived from stem cells could be a novel cell-free therapeutic strategy in regenerative medicine.
With continued expansion of the aged population, the number of patients with retinal degeneration, which is a leading cause of vision loss worldwide, is growing. Stem cell therapies offer hope for regeneration and repair of damaged retinal tissue. Recent reports have highlighted stem cell-derived paracrine mediators, such as exosomes, which appear to exert a therapeutic benefit similar to their cell of origin and do not carry the risk of cell transplantation. One speculated role is that exosomes likely mediate intercellular communication and material exchange. This review depicts the molecular mechanisms underlying exosome-based therapy, especially in retina degeneration diseases. In the future, the use of stem cell-derived exosomes could be considered a novel and cell-free therapeutic strategy in regenerative medicine.
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