Cell compartments and intracellular trafficking of lipids and proteins: Impact on biomedicine

Article Biochemistry & Molecular Biology

Endolysosomal cholesterol export: More than just NPC1

Albert Lu

Summary: NPC1 plays a central role in cholesterol egress from endolysosomes, but alternative pathways may exist. Understanding these mechanisms could have important implications for lysosomal storage disorder therapies.

BIOESSAYS (2022)

Add to Collection

Article Multidisciplinary Sciences

Acidification of endothelial Weibel-Palade bodies is mediated by the vacuolar-type H+-ATPase

Julian Terglane et al.

Summary: This study demonstrates that the vacuolar-type H+-ATPase on Weibel-Palade bodies is necessary for proper acidification and maturation of the organelle.

PLOS ONE (2022)

Add to Collection

Review Cell Biology

ER as master regulator of membrane trafficking and organelle function

Eva Maria Wenzel et al.

Summary: The endoplasmic reticulum regulates the positioning, dynamics, and functions of other organelles through membrane contact sites. It controls organelles such as endosomes, lysosomes, autophagosomes, mitochondria, peroxisomes, and the Golgi apparatus through lipid and Ca2+ transfer, phosphorylation reactions, and control of organelle motility, fusion, and fission.

JOURNAL OF CELL BIOLOGY (2022)

Add to Collection

Article Cell Biology

PI4P/PS countertransport by ORP10 at ER-endosome membrane contact sites regulates endosome fission

Asami Kawasaki et al.

Summary: This study reveals that ORP10 mediates lipid countertransport at ER-endosome MCSs, supplying endosomes with phosphatidylserine (PS) in exchange for phosphatidylinositol 4-phosphate (PI4P), thereby promoting EHD1 recruitment and endosome fission.

JOURNAL OF CELL BIOLOGY (2021)

Add to Collection

Article Biology

V-ATPase V0a1 promotes Weibel-Palade body biogenesis through the regulation of membrane fission

Yasuo Yamazaki et al.

Summary: V0a1 is identified as a crucial factor for membrane fission of Weibel-Palade bodies (WPBs) in vascular endothelial cells, while protein kinase D (PKD) is found to be essential for WPB biogenesis. The discovery of V0a1 as a new membrane fission regulator is expected to improve understanding of the molecular events enabling membrane fission.

ELIFE (2021)

Add to Collection

Review Cell Biology