The role of WNT10B in physiology and disease: A 10-year update

WNT10B, a member of the WNT family of secreted glycoproteins, activates the WNT/beta-catenin signaling cascade to control proliferation, stemness, pluripotency, and cell fate decisions. WNT10B plays roles in many tissues, including bone, adipocytes, skin, hair, muscle, placenta, and the immune system. Aberrant WNT10B signaling leads to several diseases, such as osteoporosis, obesity, split-hand/foot malformation (SHFM), fibrosis, dental anomalies, and cancer. We reviewed WNT10B a decade ago, and here we provide a comprehensive update to the field. Novel research on WNT10B has expanded to many more tissues and diseases. WNT10B polymorphisms and mutations correlate with many phenotypes, including bone mineral density, obesity, pig litter size, dog elbow dysplasia, and cow body size. In addition, the field has focused on the regulation of WNT10B using upstream mediators, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). We also discussed the therapeutic implications of WNT10B regulation. In summary, research conducted during 2012-2022 revealed several new, diverse functions in the role of WNT10B in physiology and disease.

Automated summary

WNT10B, a member of the WNT family, plays a crucial role in controlling proliferation, stemness, pluripotency, and cell fate decisions through the WNT/beta-catenin signaling cascade. It is involved in various tissues and diseases, including bone, adipocytes, skin, hair, muscle, placenta, and the immune system. Mutations and polymorphisms of WNT10B are associated with phenotypes such as bone mineral density, obesity, pig litter size, dog elbow dysplasia, and cow body size. The regulation of WNT10B using microRNAs and long non-coding RNAs has been a focus of research, and therapeutic implications have also been discussed.