☆ 4.7 Review

The roles of lncRNA functions and regulatory mechanisms in the diagnosis and treatment of hepatocellular carcinoma

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Nanoparticles (NPs)-Meditated LncRNA AFAP1-AS1 Silencing to Block Wnt/β-Catenin Signaling Pathway for Synergistic Reversal of Radioresistance and Effective Cancer Radiotherapy

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Non-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironment

Wenyu Wang et al.

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EMT, MET, Plasticity, and Tumor Metastasis

Basil Bakir et al.

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Targeting STAT3 in Cancer Immunotherapy

Sailan Zou et al.

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The role of ubiquitination and deubiquitination in cancer metabolism

Tianshui Sun et al.

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Aberrant NSUN2-mediated m5C modification of H19 lncRNA is associated with poor differentiation of hepatocellular carcinoma

Zhen Sun et al.

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Gene signatures and prognostic values of m1A-related regulatory genes in hepatocellular carcinoma

Qingmiao Shi et al.

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A p53/lnc-Ip53 Negative Feedback Loop Regulates Tumor Growth and Chemoresistance

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RNA, Genome Output and Input

Jorg Morf et al.

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Suppression of lncRNA MALAT1 by betulinic acid inhibits hepatocellular carcinoma progression by targeting IAPs via miR-22-3p

Feiyu Chen et al.

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Long noncoding RNA CASC11 promotes hepatocarcinogenesis and HCC progression through EIF4A3-mediated E2F1 activation

Hang Song et al.

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Role of RNA modifications in cancer

Isaia Barbieri et al.

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Exosomes: key players in cancer and potential therapeutic strategy

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LncRNA CSMD1-1 promotes the progression of Hepatocellular Carcinoma by activating MYC signaling

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Prediagnostic dietary intakes of vitamin A and beta-carotene are associated with hepatocellular-carcinoma survival

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The small peptide world in long noncoding RNAs

Seo-Won Choi et al.

BRIEFINGS IN BIOINFORMATICS (2019)

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A Transforming Growth Factor-β and H19 Signaling Axis in Tumor-Initiating Hepatocytes That Regulates Hepatic Carcinogenesis

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A Long Noncoding RNA Regulates Hepatitis C Virus Infection Through Interferon Alpha-Inducible Protein 6

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Interchromosomal interactions: A genomic love story of kissing chromosomes

Philipp G. Maass et al.

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Genome-wide methods for investigating long noncoding RNAs

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Genome-Wide Screening and Functional Analysis Identifies Tumor Suppressor Long Noncoding RNAs Epigenetically Silenced in Hepatocellular Carcinoma

Feiyue Xu et al.

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Long Noncoding RNA MALAT1 Regulates Cancer Glucose Metabolism by Enhancing mTOR-Mediated Translation of TCF7L2

Pushkar Malakar et al.

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Extracellular Vesicles Long RNA Sequencing Reveals Abundant mRNA, circRNA, and lncRNA in Human Blood as Potential Biomarkers for Cancer Diagnosis

Yuchen Li et al.

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Aflatoxin B1: A review on metabolism, toxicity, occurrence in food, occupational exposure, and detoxification methods

Blake R. Rushing et al.

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Lnc-UCID Promotes G1/S Transition and Hepatoma Growth by Preventing DHX9-Mediated CDK6 Down-regulation

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HEPATOLOGY (2019)

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Ferroptosis, a new form of cell death: opportunities and challenges in cancer

Yanhua Mou et al.

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A novel lncRNA MCM3AP-AS1 promotes the growth of hepatocellular carcinoma by targeting miR-194-5p/FOXA1 axis

Yufeng Wang et al.

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Global Positioning System: Understanding Long Noncoding RNAs through Subcellular Localization

Joana Carlevaro-Fita et al.

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Interplay between early-life malnutrition, epigenetic modulation of the immune function and liver diseases

Sabrina Campisano et al.

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LncRNA SNHG10 Facilitates Hepatocarcinogenesis and Metastasis by Modulating Its Homolog SCARNA13 via a Positive Feedback Loop

Tian Lan et al.

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Epigenetic alterations caused by aflatoxin b1: a public health risk in the induction of hepatocellular carcinoma

Roseane Guimaraes Ferreira et al.

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Mechanisms underlying aflatoxin-associated mutagenesis - Implications in carcinogenesis

Amanda K. McCullough et al.

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Surveillance for Hepatocellular Carcinoma: Current Best Practice and Future Direction

Fasiha Kanwal et al.

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A Tale of Two Complications of Obesity: NASH and Hepatocellular Carcinoma

Renumathy Dhanasekaran et al.

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Mechanisms associated with biogenesis of exosomes in cancer

Kathleen M. McAndrews et al.

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Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma

Liang Yang et al.

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RNA modifications regulating cell fate in cancer

Sylvain Delaunay et al.

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Roles and Regulation of Long Noncoding RNAs in Hepatocellular Carcinoma

Lee Jin Lim et al.

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LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling

Yanying Wang et al.

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Liquid biopsy in hepatocellular carcinoma: circulating tumor cells and circulating tumor DNA

Qianwei Ye et al.

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The molecular mechanism of LncRNA34a-mediated regulation of bone metastasis in hepatocellular carcinoma

Li Zhang et al.

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Aspirin targets P4HA2 through inhibiting NF-κB and LMCD1-AS1/let-7g to inhibit tumour growth and collagen deposition in hepatocellular carcinoma

Tianjiao Wang et al.

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Identification of Coding and Long Noncoding RNAs Differentially Expressed in Tumors and Preferentially Expressed in Healthy Tissues

Juan P. Unfried et al.

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An LTR retrotransposon-derived lncRNA interacts with RNF169 to promote homologous recombination

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Alcohol or Gut Microbiota: Who Is the Guilty?

Marica Meroni et al.

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Recent Progress in Ferroptosis Inducers for Cancer Therapy

Chen Liang et al.

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Smart cancer nanomedicine

Roy van der Meel et al.

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Super-Enhancer-Associated Long Noncoding RNA HCCL5 Is Activated by ZEB1 and Promotes the Malignancy of Hepatocellular Carcinoma

Li Peng et al.

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Impact of direct-acting antivirals on early recurrence of HCV-related HCC: Comparison with interferon-based therapy

Mizuki Nishibatake Kinoshita et al.

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Current and future perspectives of liquid biopsies in genomics-driven oncology

Ellen Heitzer et al.

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KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3

Tian Lan et al.

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Revealing lncRNA Structures and Interactions by Sequencing-Based Approaches

Xingyang Qian et al.

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EMT Transition States during Tumor Progression and Metastasis

Ievgenia Pastushenko et al.

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LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway

Yin-Li Zheng et al.

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LncRNA AY promotes hepatocellular carcinoma metastasis by stimulating ITGAV transcription

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LncRNA PCNAP1 modulates hepatitis B virus replication and enhances tumor growth of liver cancer

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Long noncoding RNA TSLNC8 is a tumor suppressor that inactivates the interleukin-6/STAT3 signaling pathway

Jiwei Zhang et al.

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AASLD guidelines for the treatment of hepatocellular carcinoma

Julie K. Heimbach et al.

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Targeted nanocomplex carrying siRNA against MALAT1 sensitizes glioblastoma to temozolomide

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Alcohol and hepatitis virus-dysregulated lncRNAs as potential biomarkers for hepatocellular carcinoma

Hao Zheng et al.

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SNHG6 Acts as a Genome-Wide Hypomethylation Trigger via Coupling of miR-1297-Mediated S-Adenosylmethionine-Dependent Positive Feedback Loops

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Noncoding RNA:RNA Regulatory Networks in Cancer

Jia Jia Chan et al.

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The risk of hepatocellular carcinoma in cirrhotic patients with hepatitis C and sustained viral response: Role of the treatment regimen

Hamish Innes et al.

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The HNF1α-regulated lncRNA HNF1A-AS1 reverses the malignancy of hepatocellular carcinoma by enhancing the phosphatase activity of SHP-1

Chen-Hong Ding et al.

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Long non-coding RNA NEAT1-modulated abnormal lipolysis via ATGL drives hepatocellular carcinoma proliferation

Xirui Liu et al.

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Long noncoding RNA HULC accelerates liver cancer by inhibiting PTEN via autophagy cooperation to miR15a

Xiaoru Xin et al.

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The long non-coding RNA PTTG3P promotes cell growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in hepatocellular carcinoma

Jin-lan Huang et al.

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Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation

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RNA-modifying proteins as anticancer drug targets

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Biogenesis and function of extracellular vesicles in cancer

Maarten P. Bebelman et al.

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Long Noncoding RNA in Cancer: Wiring Signaling Circuitry

Chunru Lin et al.

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The LINCO1138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma

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Long noncoding RNA miR503HG, a prognostic indicator, inhibits tumor metastasis by regulating the HNRNPA2B1/NF-kappa B pathway in hepatocellular carcinoma

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Identification and Functional Characterization of Long Non-coding RNA MIR22HG as a Tumor Suppressor for Hepatocellular Carcinoma

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Hepatitis B virus infection

Nature Reviews Disease Primers (2018)

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Lnc-PCDH9-13:1 Is a Hypersensitive and Specific Biomarker for Early Hepatocellular Carcinoma

Zijun Xie et al.

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Molecular therapies and precision medicine for hepatocellular carcinoma

Josep M. Llovet et al.

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Association Between Aspirin Use and Risk of Hepatocellular Carcinoma

Tracey G. Simon et al.

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Long noncoding RNA: a crosslink in biological regulatory network

Yuwei Zhang et al.

BRIEFINGS IN BIOINFORMATICS (2018)

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Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers

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GUT (2017)

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Non- metabolic functions of glycolytic enzymes in tumorigenesis

X. Yu et al.

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Long non-coding RNA CASC2 suppresses epithelial-mesenchymal transition of hepatocellular carcinoma cells through CASC2/miR-367/FBXW7 axis

Yufeng Wang et al.

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STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4

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Profiling, clinicopathological correlation and functional validation of specific long non-coding RNAs for hepatocellular carcinoma

Jian Yao et al.

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Dysregulated long noncoding RNAs (lncRNAs) in hepatocellular carcinoma: implications for tumorigenesis, disease progression, and liver cancer stem cells

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The noncoding RNA HOXD-AS1 is a critical regulator of the metastasis and apoptosis phenotype in human hepatocellular carcinoma

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Hepatitis B virus X protein promotes the development of liver fibrosis and hepatoma through downregulation of miR-30e targeting P4HA2 mRNA

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LncRNA-mediated regulation of cell signaling in cancer

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Mesenchymal Stem Cells Promote Hepatocarcinogenesis via lncRNA-MUF Interaction with ANXA2 and miR-34a

Xinlong Yan et al.

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Cancer Stem Cells: Basic Concepts and Therapeutic Implications

Dany Nassar et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 11 (2016)

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Unexpected high rate of early tumor recurrence in patients with HCV-related HCC undergoing interferon-free therapy

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Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

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Distinct response of the hepatic transcriptome to Aflatoxin B1 induced hepatocellular carcinogenesis and resistance in rats

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Autophagy, Metabolism, and Cancer

Eileen White et al.

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Hepatocellular Carcinoma From Epidemiology to Prevention: Translating Knowledge into Practice

Amit G. Singal et al.

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The landscape of long noncoding RNAs in the human transcriptome

Matthew K. Iyer et al.

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HEPATITIS Epigenetic control of HBV by HBx protein-releasing the break?

Ulrike Protzer

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SHP-1 is a negative regulator of epithelial-mesenchymal transition in hepatocellular carcinoma

L-C Fan et al.

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Hepatocyte-Specific Ptpn6 Deletion Promotes Hepatic Lipid Accretion, but Reduces NAFLD in Diet-Induced Obesity: Potential Role of PPARγ

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Cellular senescence: from physiology to pathology

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Signaling through cyclin D-dependent kinases

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Immunobiology and Conflicting Roles of the Human NKG2D Lymphocyte Receptor and Its Ligands in Cancer

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Hepatitis B virus-induced hepatocellular carcinoma: functional roles of MICA variants

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Dovitinib Induces Apoptosis and Overcomes Sorafenib Resistance in Hepatocellular Carcinoma through SHP-1-Mediated Inhibition of STAT3

Wei-Tien Tai et al.

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Hepatic stem cells and transforming growth factor β in hepatocellular carcinoma

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ENCODE whole-genome data in the UCSC Genome Browser: update 2012

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SHP-1 in Cell-Cycle Regulation

Pilar Lopez-Ruiz et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2011)

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NF-kappa B and STAT3 - key players in liver inflammation and cancer

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Role of cancer stem cells in hepatocarcinogenesis

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H19 acts as a trans regulator of the imprinted gene network controlling growth in mice

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Long intronic noncoding RNA transcription: Expression noise or expression choice?

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STATs in cancer inflammation and immunity: a leading role for STAT3

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Transforming growth factor-β gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer

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The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis

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Alcohol, tobacco and obesity are synergistic risk factors for hepatocellular carcinoma

JA Marrero et al.

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Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation

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Hepatocyte nuclear factor-1α is an essential regulator of bile acid and plasma cholesterol metabolism

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DNA double-strand breaks: signaling, repair and the cancer connection

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