The multifaceted virulence of adherent-invasive Escherichia coli

The surge in inflammatory bowel diseases, like Crohn's disease (CD), is alarming. While the role of the gut microbiome in CD development is unresolved, the frequent isolation of adherent-invasive Escherichia coli (AIEC) strains from patient biopsies, together with their propensity to trigger gut inflammation, underpin the potential role of these bacteria as disease modifiers. In this review, we explore the spectrum of AIEC pathogenesis, including their metabolic versatility in the gut. We describe how AIEC strains hijack the host defense mechanisms to evade immune attrition and promote inflammation. Furthermore, we highlight the key traits that differentiate AIEC from commensal E. coli. Deciphering the main components of AIEC virulence is cardinal to the discovery of the next generation of antimicrobials that can selectively eradicate CD-associated bacteria.

Automated summary

The surge in inflammatory bowel diseases indicates the potential role of adherent-invasive Escherichia coli (AIEC) strains as disease modifiers. Understanding AIEC pathogenesis, including their metabolic versatility, evasion of host defense mechanisms, and promotion of inflammation, is crucial for developing antimicrobials that can selectively eradicate CD-associated bacteria.