Neuronal activity in the human amygdala and hippocampus enhances emotional memory encoding

Emotional events comprise our strongest and most valuable memories. Here we examined how the brain prioritizes emotional information for storage using direct brain recording and deep brain stimulation. First, 148 participants undergoing intracranial electroencephalographic (iEEG) recording performed an episodic memory task. Participants were most successful at remembering emotionally arousing stimuli. High-frequency activity (HFA), a correlate of neuronal spiking activity, increased in both the hippocampus and the amygdala when participants successfully encoded emotional stimuli. Next, in a subset of participants (N = 19), we show that applying high-frequency electrical stimulation to the hippocampus selectively diminished memory for emotional stimuli and specifically decreased HFA. Finally, we show that individuals with depression (N = 19) also exhibit diminished emotion-mediated memory and HFA. By demonstrating how direct stimulation and symptoms of depression unlink HFA, emotion and memory, we show the causal and translational potential of neural activity in the amygdalohippocampal circuit for prioritizing emotionally arousing memories. Qasim et al. examine how emotion affects memory using direct brain recording and deep brain stimulation.

Automated summary

In this study, the impact of emotion on memory was investigated using direct brain recording and deep brain stimulation. The findings show that emotional events have a significant influence on memory storage, with the brain prioritizing emotional information. Additionally, individuals with depression were found to have deficits in emotion-mediated memory and brain activity.