Journal
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
Volume 310, Issue 2, Pages 515-522Publisher
SPRINGER
DOI: 10.1007/s10967-016-4805-6
Keywords
Gemcitabine HCl; Bladder cancer; Radiolabeled microsphere; Cell incorporation
Funding
- Scientific and Technological Research Council of Turkey [TUBITAK-112/S/293]
- T.R. Prime Ministry State Planning Organization Foundation [09/DPT/001]
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In the present study incorporation differences between the developed formulations for treatment for bladder cancer was investigated by radioactive cell culture studies. Developed bioadhesive microspheres (MS) and gemcitabinehydrochloride loaded MS (GHCl-MS) were radiolabeled. After observing the optimum labeling conditions, Tc-99m-MS and Tc-99m-GHCl-MS were loaded to the chitosan gel (CG) and poloxamer gel. The in vitro cell incorporation affinity of newly developed formulations to bladder papilloma (RT4) and the carcinoma (T24) cell lines was investigated. Cell culture studies results indicate that the use of prolonged release bioadhesive CG formulation was highly improved the targeting of the GHCl to the cancer cells.
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