Allogeneic stem cell transplantation in the treatment of acute myeloid leukemia: An overview of obstacles and opportunities

Article Oncology

FLT3 inhibitors as maintenance therapy post allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients with FLT3 mutations: A meta-analysis

Xinhong Fei et al.

Summary: The meta-analysis reveals that post-transplant FLT3i maintenance therapy can improve survival and reduce relapse in FLT3-mutated AML patients, and it is well-tolerated.

CANCER MEDICINE (2023)

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Article Surgery

Immune reconstitution and survival of patients after allogeneic hematopoietic stem cell transplantation from older donors

Peiyao Jiang et al.

Summary: This study retrospectively compared the outcomes of allogeneic peripheral blood stem cell transplantation (PBSCT) in patients with donors under 50 years and donors over 50 years of age. The results showed that patients in the older donor group had inferior immune reconstitution and higher EBV reactivation rates, but there was no change in overall survival.

CLINICAL TRANSPLANTATION (2023)

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Article Oncology

Measurable residual disease, FLT3-ITD mutation, and disease status have independent prognostic influence on outcome of allogeneic stem cell transplantation in NPM1-mutated acute myeloid leukemia

Rama Al Hamed et al.

Summary: The presence of FLT3-ITD mutation, MRD positivity, and disease status significantly influence the posttransplant outcomes in patients with NPM1-mutated AML, highlighting the importance of identifying high-risk patients for potential posttransplant interventions to prevent relapse.

CANCER MEDICINE (2022)

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Review Medicine, General & Internal

Prevention and Treatment of Acute Myeloid Leukemia Relapse after Hematopoietic Stem Cell Transplantation: The State of the Art and Future Perspectives

Salvatore Leotta et al.

Summary: Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative option for high-risk acute myeloid leukemia (AML). Advances in pre-transplant induction therapies, supportive care, donor selection, and conditioning regimens have expanded the patient population eligible for HSCT. The introduction of novel agents and targeted therapies have enriched the treatment landscape for AML relapse after HSCT, while close monitoring of minimal-residual disease (MRD) and preemptive strategies have become essential in post-transplant care.

JOURNAL OF CLINICAL MEDICINE (2022)

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Review Oncology

Challenges and Advances in Chimeric Antigen Receptor Therapy for Acute Myeloid Leukemia

Jennifer Marvin-Peek et al.

Summary: CAR therapy has been effective in treating B-cell mediated cancers, but faces challenges in treating AML. This review discusses the difficulties in developing CAR therapy for AML and recent advances in the field. Continued improvement in AML CAR therapy would have a significant impact on this disease.

CANCERS (2022)

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Review Oncology

CARving the Path to Allogeneic CAR T Cell Therapy in Acute Myeloid Leukemia

Oren Pasvolsky et al.

Summary: This review discusses the advances in immunotherapy for acute myeloid leukemia (AML), with a focus on chimeric antigen receptor (CAR) T cell therapy. CAR T cell therapy has shown clinical success in B-cell malignancies. However, there are challenges in applying CAR T cell therapy to AML, but some progress has been made in preclinical and clinical research.

FRONTIERS IN ONCOLOGY (2022)

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Review Immunology

Review: HLA loss and detection in the setting of relapse from HLA-mismatched hematopoietic cell transplant

Paula Y. Arnold

Summary: HLA loss is rare at diagnosis in hematologic malignancies but may occur in leukemic cells at disease relapse. HLA loss may render leukemic cells resistant to donor graft vs. leukemia effects. The use of alloreactive T cells to control relapse may not be effective and carries the risk of graft vs. host disease. Assessment of HLA loss is important for making decisions regarding appropriate therapies and donor selection for rescue HCT.

HUMAN IMMUNOLOGY (2022)

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Article Immunology

Pretransplantation minimal residual disease monitoring by multiparameter flow cytometry predicts outcomes of AML patients receiving allogeneic hematopoietic stem cell transplantation

Yun Zhang et al.

Summary: This study aimed to investigate the prognostic role of residual disease (MRD) monitoring by multiparameter flow cytometry (MFC) in acute myeloid leukemia (AML) patients before allogeneic hemopoietic stem cell transplantation (allo-HSCT), and to determine the impact of MRD eradication on guiding the timing of HSCT. The findings revealed that achieving MFC-MRD <10-3 significantly reduced the risk of AML relapse and improved overall survival (OS) and disease-free survival (DFS) for patients. Haplo-HSCT may be a preferred option for patients who did not achieve MRD negativity.

TRANSPLANT IMMUNOLOGY (2022)

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Article Oncology

Emerging CAR T Cell Strategies for the Treatment of AML

Paresh Vishwasrao et al.

Summary: CAR-T cell therapy is a promising cancer treatment method, but it also brings about some immune-related toxicities. Impressive results have been achieved in treating B cell hematological malignancies, but further research is needed for other hematological malignancies. This article summarizes the findings from preclinical and human studies of CAR-T cell therapy and discusses new treatment targets.

CANCERS (2022)

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Review Medicine, General & Internal

Maintenance With Hypomethylating Agents After Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia and Myelodysplastic Syndrome: A Systematic Review and Meta-Analysis

Smith Kungwankiattichai et al.

Summary: This systematic review and meta-analysis demonstrated that AML and MDS patients who received HMA maintenance after allo-SCT had improved outcomes in terms of overall survival (OS), relapse-free survival (RFS), non-relapse mortality (NRM), cumulative incidence of relapse (CIR), and a reduced incidence of chronic graft-vs.-host disease (GVHD).

FRONTIERS IN MEDICINE (2022)

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Article Medicine, General & Internal

Assessment of Patient-Specific Human Leukocyte Antigen Genomic Loss at Relapse After Antithymocyte Globulin-Based T-Cell-Replete Haploidentical Hematopoietic Stem Cell Transplant

Hengwei Wu et al.

Summary: HLA loss frequently occurs at leukemia relapse after ATG-based haploidentical HSCT. Identifying the risk factors associated with HLA loss can help prompt screening, avoid potentially harmful infusions of donor T cells, and develop alternative therapeutic strategies.

JAMA NETWORK OPEN (2022)

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Review Biology

Lessons Learned from Donor Cell-Derived Myeloid Neoplasms: Report of Three Cases and Review of the Literature

Komal Galani Deshmukh et al.

Summary: This study describes three additional cases of donor-cell derived myeloid neoplasm (DDMN) and reviews the cytogenetic profiles of previously reported cases. It highlights the importance of therapy-related myeloid neoplasms in DDMN and discusses the potential roles of direct transfer of leukemic cells, genomic instability, abnormal gene methylation, abnormal stromal niche, and immunological surveillance in the pathogenesis of donor-derived leukemias.

LIFE-BASEL (2022)

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Article Oncology

Safe and effective off-the-shelf immunotherapy based on CAR.CD123-NK cells for the treatment of acute myeloid leukaemia

Simona Caruso et al.

Summary: The study demonstrates the potential of using off-the-shelf CAR.CD123-NK cells as a therapeutic strategy for paediatric AML patients, showing significant anti-leukaemia activity and improved safety compared to CAR.CD123-T cells.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

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Article Hematology

Relapse after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia: an overview of prevention and treatment

Firas Kreidieh et al.

Summary: This article provides an overview of prevention and treatment of relapse in patients with acute myeloid leukemia (AML) post-allogeneic hematopoietic stem cell transplantation (allo-HSCT), including cell-based and pharmacologic options. The effectiveness of post-transplant maintenance therapy, pre-emptive treatment, and prophylactic donor lymphocyte infusion (DLI) in preventing relapse is discussed. Targeted post-transplant pharmacological interventions and the potential role of CAR-T cells in AML are also mentioned.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2022)

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Article Hematology

Sorafenib maintenance after hematopoietic stem cell transplantation improves outcome of FLT3-ITD-mutated acute myeloid leukemia

Semra Aydin et al.

Summary: In a retrospective analysis, the effectiveness of sorafenib maintenance therapy for patients with acute myeloid leukemia (AML) was evaluated. The study found that sorafenib maintenance significantly improved the cumulative incidence of relapse and overall survival, especially in AML patients with FLT3-ITD mutation.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2022)

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Article Multidisciplinary Sciences

Memory-like NK cells armed with a neoepitope-specific CAR exhibit potent activity against NPM1 mutated acute myeloid leukemia

Han Dong et al.

Summary: Acute myeloid leukemia (AML) is difficult to treat due to a lack of tumor-specific targets for immune-based therapies. Recent studies have shown that natural killer (NK) cells exhibit innate memory and enhanced antitumor activity when activated with IL-12 and IL-18. This study demonstrates that arming CIML NK cells with a neoepitope-specific CAR significantly improves their antitumor responses to NPM1-mutated AML and avoids off-target toxicity.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Hematology

Patient age and donor HLA matching can stratify allogeneic hematopoietic cell transplantation patients into prognostic groups

Alejandro Garcia-Horton et al.

Summary: This study found that a simple scoring system accurately predicts overall survival and non-relapse mortality in allogeneic hematopoietic stem cell transplant patients. The scoring system is based on the recipient's age and HLA mismatch status and is a helpful tool for clinicians and patients in making clinical decisions.

EUROPEAN JOURNAL OF HAEMATOLOGY (2022)

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Article Biochemistry & Molecular Biology

Preclinical Evaluation of CRISPR-Edited CAR-NK-92 Cells for Off-the-Shelf Treatment of AML and B-ALL

Guillermo Urena-Bailen et al.

Summary: Acute myeloid leukemia (AML) and B-cell acute lymphocytic leukemia (B-ALL) are severe blood malignancies. CAR-based immunotherapies have shown effectiveness in their treatment, but immune escape remains a challenge. Researchers transduced NK-92 cells with CD276-CAR or CD19-CAR constructs and attempted to enhance cytotoxicity by knocking out inhibitory checkpoints using CRISPR-Cas9 technology. The generated cell lines demonstrated targeted cytotoxicity and enhanced antileukemic function.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Oncology

Outcomes with mismatched unrelated donor allogeneic hematopoietic stem cell transplantation in adults: A systematic review and meta-analysis

Muhammad Umair Mushtaq et al.

Summary: A systematic review and meta-analysis evaluated the outcomes of mismatched unrelated donor hematopoietic stem cell transplantation (MMUD-HSCT). The results showed that MMUD-HSCT had favorable treatment outcomes and an acceptable toxicity profile in patients lacking HLA-matched or haploidentical donors, thus expanding the accessibility of HSCT to underrepresented populations.

FRONTIERS IN ONCOLOGY (2022)

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Article Hematology

Enasidenib as maintenance following allogeneic hematopoietic cell transplantation for IDH2-mutated myeloid malignancies

Amir T. Fathi et al.

Summary: This study evaluated the efficacy of enasidenib maintenance therapy in patients with IDH2-mutated myeloid malignancies following hematopoietic cell transplantation. The results demonstrated that enasidenib is safe and well-tolerated and has potential as a maintenance therapy for patients with IDH2-mutated AML. Further research is warranted.

BLOOD ADVANCES (2022)

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Review Cell Biology

The genesis and evolution of acute myeloid leukemia stem cells in the microenvironment: From biology to therapeutic targeting

Yongfeng Chen et al.

Summary: Acute myeloid leukemia (AML) patients often develop chemotherapeutic resistance and relapse, primarily due to the presence of leukemic stem cells (LSCs). LSCs possess stem cell properties and can adapt to the action of chemotherapy in the bone marrow microenvironment (BMM). Understanding the relationship between LSCs and the BMM can improve treatment outcomes for AML.

CELL DEATH DISCOVERY (2022)

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Article Hematology

Impact of Cytogenetic Risk on Outcomes of Non-T-Cell-Depleted Haploidentical Hematopoietic Cell Transplantation in Patients with Relapsed or Refractory Acute Myeloid Leukemia

Arnon Nagler et al.

Summary: This study analyzed the impact of baseline cytogenetic risk on the outcomes of nonT-cell-depleted Haplo-HCT in patients with active disease relapsed or refractory (R/R) acute myeloid leukemia (AML). It found that baseline cytogenetic risk remains a key prognostic factor for patients with R/R AML before undergoing non-T-cell-depleted Haplo-HCT.

TRANSPLANTATION AND CELLULAR THERAPY (2022)

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Review Hematology

Hematopoietic Cell Transplantation in the Treatment of Newly Diagnosed Adult Acute Myeloid Leukemia: An Evidence-Based Review from the American Society of Transplantation and Cellular Therapy

Bhagirathbhai Dholaria et al.

Summary: This evidence-based review examines the role of hematopoietic cell transplantation (HCT) in the management of newly diagnosed adult acute myeloid leukemia (AML) and recommends the preferential use of allogeneic HCT with myeloablative conditioning in eligible patients. Allogeneic HCT offers a survival benefit in intermediate- and high-risk AML patients and is now considered part of standard clinical care.

TRANSPLANTATION AND CELLULAR THERAPY (2021)

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Review Biology

Liquid Biopsy and Potential Liquid Biopsy-Based Biomarkers in Philadelphia-Negative Classical Myeloproliferative Neoplasms: A Systematic Review

Mihnea-Alexandru Gaman et al.

Summary: Myeloproliferative neoplasms are clonal disorders of hematopoietic stem cells. Liquid biopsy and biomarkers have potential diagnostic and prognostic applications in MPNs, but further research is needed to confirm their utility for differentiating subtypes and predicting thrombosis development.

LIFE-BASEL (2021)

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Article Hematology

Impact of luteinizing hormone suppression on hematopoietic recovery after intensive chemotherapy in patients with leukemia

Iman Abou Dalle et al.

Summary: The study showed that the use of leuprolide in leukemia patients undergoing intensive chemotherapy was associated with improved long-term blood count recovery and reduced transfusion requirements in acute myeloid leukemia (AML).

HAEMATOLOGICA (2021)

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Review Oncology

Maintenance therapy in acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation

Li Xuan et al.

Summary: Relapse is still the main reason for treatment failure in AML patients undergoing allo-HSCT. Evidence suggests that maintenance therapy post-transplantation, particularly targeted drugs like hypomethylating agents, FLT3 inhibitors, and isocitrate dehydrogenase inhibitors, could benefit AML patients, especially those at high risk.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Oncology

Acute Myeloid Leukemia, Version 2.2021 Featured Updates to the NCCN Guidelines

Daniel A. Pollyea et al.

Summary: The NCCN Guidelines for Acute Myeloid Leukemia provide recommendations for the diagnosis and treatment of adults with AML based on clinical trials that have led to significant improvements in treatment. Recent updates focus on familial genetic alterations, treatment strategies for low-risk and favorable-risk AML, venetoclax-based therapies, and considerations for patients who prefer not to receive blood transfusions.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2021)

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Article Cell & Tissue Engineering

Phase I clinical trial of intra-bone marrow cotransplantation of mesenchymal stem cells in cord blood transplantation

Tatsunori Goto et al.

Summary: This study demonstrated the safety of MSC-CBT and suggested that cotransplantation of MSCs may prevent GVHD without inhibiting engraftment.

STEM CELLS TRANSLATIONAL MEDICINE (2021)

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Review Cell Biology

Manipulating the Metabolism to Improve the Efficacy of CAR T-Cell Immunotherapy

Marsha Pellegrino et al.

Summary: The adoptive transfer of CAR-expressing T cells has shown unprecedented success in treating B-cell malignancies, but its efficacy in other types of cancers is still limited. The metabolic fitness of CAR T cells plays a crucial role in their ability to target and function within solid tumors, with both tumor and T cell metabolism impacting the immune response significantly.

CELLS (2021)

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Article Hematology

Overcoming graft failure after haploidentical transplantation: Is this a possibility?

Xiao-Jun Huang

Summary: Allogeneic hematopoietic stem cell transplantation, including haploidentical HSCT, is a potential curative treatment for hematologic disorders, but poor graft function can lead to mortality. Advancements in conditioning regimens and strategies to improve engraftment while reducing PGF are expected to enhance outcomes. This review examines recent evidence to provide insights on reducing graft failure in haplo-HSCT.

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY (2021)

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Article Biophysics

Impact of infused CD34+stem cell dosing for allogeneic peripheral blood stem cell transplantation with post-transplant cyclophosphamide

Elmariah Hany et al.

Summary: Higher infused total nucleated cell dose in allogeneic bone marrow transplant with post-transplant cyclophosphamide is associated with improved overall survival. The study suggests that infused CD34+ cell doses >= 5 x 10(6) cells/kg may result in improved survival in patients receiving allogeneic PBSCT with PTCy. Targeting a CD34+ cell dose of >= 5 x 10(6) cells/kg for allogeneic PBSCT with PTCy is supported by these findings.

BONE MARROW TRANSPLANTATION (2021)

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Review Biophysics

Genetics of donor cell leukemia in acute myelogenous leukemia and myelodysplastic syndrome

Lacey Williams et al.

Summary: Allogeneic hematopoietic stem cell transplantation is effective for acute myelogenous leukemia patients, but some may experience leukemia recurrence, including donor-derived leukemias. Recent advances in genetic sequencing have identified candidate genes that contribute to leukemia development in donor cells. Family clustering studies and animal experiments support the potential role of these genetic variants in AML development.

BONE MARROW TRANSPLANTATION (2021)

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Article Genetics & Heredity

Comprehensive analysis of mutations and clonal evolution patterns in a cohort of patients with cytogenetically normal acute myeloid leukemia

Yuslina Mat Yusoff et al.

Summary: The study identified somatic mutations in matched presentation and relapsed samples from 6 CN-AML patients, with an average of 4.0 variants per patient at presentation and 5.3 variants per patient at relapse. The findings suggest that relapse-initiating clones may pre-exist prior to therapy and acquire mutations that confer selective advantage during chemotherapy.

MOLECULAR CYTOGENETICS (2021)

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Review Cell Biology

Redox Control in Acute Lymphoblastic Leukemia: From Physiology to Pathology and Therapeutic Opportunities

Yongfeng Chen et al.

Summary: Recent studies have shown that redox dysregulation plays a significant role in the development and progression of acute lymphoblastic leukemia (ALL). Pro-oxidant therapy targeting redox dysregulation has shown promising results in treating ALL patients, but drug resistance and side effects remain major challenges. Oxidative stress can activate antioxidant mechanisms in leukemia cells to escape damage, while also causing harm to hematopoietic stem cells.

CELLS (2021)

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Article Cell Biology

Combining Mobilizing Agents with Busulfan to Reduce Chemotherapy-Based Conditioning for Hematopoietic Stem Cell Transplantation

Laura Garcia-Perez et al.

Summary: In the context of HSC transplantation, current conditioning regimens have severe side effects on bone marrow and the immune system, especially for SCID patients. Research aimed to improve the efficacy of conditioning by combining established therapeutic agents with busulfan, showing moderate potential in reducing toxicity and enhancing immune recovery.

CELLS (2021)

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Article Oncology

Clinical Utility of Droplet Digital PCR to Monitor BCR-ABL1 Transcripts of Patients With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Post-chimeric Antigen Receptor19/22 T-Cell Cocktail Therapy

Yuqi Guan et al.

Summary: Ph+ ALL accounts for 20-30% of adult ALL patients, with TKIs significantly improving outcomes. Sequential infusion of CD19/22 CAR-T therapy showed promising results in achieving molecular remission, with ddPCR established as a sensitive method for MRD quantification. Patients achieving SMR3 had no recurrence, highlighting the potential of allo-HSCT as a follow-up therapy. ddPCR may serve as an alternative when nucleic acid is limited, and lack of SMR3 could indicate the need for additional treatments.

FRONTIERS IN ONCOLOGY (2021)

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Review Cell Biology

The Magic Bullet Is Here? Cell-Based Immunotherapies for Hematological Malignancies in the Twilight of the Chemotherapy Era

Nina Miazek-Zapala et al.

Summary: Despite the availability of treatments that can cure hematological malignancies, their implementation is limited by patient age and frailty, and they often come with undesirable side effects. Therefore, cell-based immunotherapy may be the optimal strategy to be successfully incorporated into standard treatment protocols in the future.

CELLS (2021)

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Review Cell Biology

KIR Receptors as Key Regulators of NK Cells Activity in Health and Disease

Joanna Debska-Zielkowska et al.

Summary: NK cells target cancer and virally infected cells, and their cytotoxic activity is regulated by signals from KIR receptors which interact with MHC I molecules. Understanding the relationship between KIR and MHC receptors can improve transplant outcomes, with donor-recipient matching, including KIR typing, potentially enhancing monitoring, individualizing treatment, and predicting post-transplant effects. This relationship also has implications for pregnancy, cancer, and adoptive therapy with NK cells.

CELLS (2021)

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Article Hematology

Treatment of allosensitized patients receiving allogeneic transplantation

Stefan O. Ciurea et al.

Summary: DSAs are a major cause of engraftment failure in HaploSCT patients. Treatment with PE, rituximab, IVIg, and donor buffy coat is effective in promoting engraftment in patients with DSAs 20,000 MFI or below.

BLOOD ADVANCES (2021)

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Article Biology

Comparison of the clinical outcomes of hematologic malignancies after myeloablative haploidentical transplantation with G-CSF/ATG and posttransplant cyclophosphamide: results from the Chinese Bone Marrow Transplantation Registry Group (CBMTRG)

Feifei Tang et al.

SCIENCE CHINA-LIFE SCIENCES (2020)

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Review Pharmacology & Pharmacy

The Role of Reactive Oxygen Species in Tumor Treatment and its Impact on Bone Marrow Hematopoiesis

Yongfeng Chen et al.

CURRENT DRUG TARGETS (2020)

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Review Hematology

The role of regulatory T cells in graft-versus-host disease management

Jennifer S. Whangbo et al.

EXPERT REVIEW OF HEMATOLOGY (2020)

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Article Oncology

Relapse-Fated Latent Diagnosis Subclones in Acute B Lineage Leukemia Are Drug Tolerant and Possess Distinct Metabolic Programs

Stephanie M. Dobson et al.

CANCER DISCOVERY (2020)

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Review Hematology

Recent progress in and challenges in cellular therapy using NK cells for hematological malignancies

Junji Tanaka et al.

BLOOD REVIEWS (2020)

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Article Cell & Tissue Engineering

Thrombopoietin enhances hematopoietic stem and progenitor cell homing by impeding matrix metalloproteinase 9 expression

Yiming Liu et al.

STEM CELLS TRANSLATIONAL MEDICINE (2020)

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Review Immunology

Key Aspects of the Immunobiology of Haploidentical Hematopoietic Cell Transplantation

Susanne H. C. Baumeister et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Cell Biology

Oxidative resistance of leukemic stem cells and oxidative damage to hematopoietic stem cells under pro-oxidative therapy

Yongfeng Chen et al.

CELL DEATH & DISEASE (2020)

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Article Cell Biology

Understanding the Synergy of NKp46 and Co-Activating Signals in Various NK Cell Subpopulations: Paving the Way for More Successful NK-Cell-Based Immunotherapy

Loris Zamai et al.

CELLS (2020)

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Article Cell Biology

HLA-DPB1 Reactive T Cell Receptors for Adoptive Immunotherapy in Allogeneic Stem Cell Transplantation

Sebastian Klobuch et al.

CELLS (2020)

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Review Cell Biology

Transposon-Based CAR T Cells in Acute Leukemias: Where Are We Going?

Chiara F. Magnani et al.

CELLS (2020)

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Review Hematology

Caught in the net: the extracellular matrix of the bone marrow in normal hematopoiesis and leukemia

Costanza Zanetti et al.

EXPERIMENTAL HEMATOLOGY (2020)

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Review Biochemistry & Molecular Biology

Targeting Histone Deacetylases to Modulate GraftVersus-Host Disease and Graft-Versus-Leukemia

Sena Kim et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Cell Biology

Wnt-5A/B Signaling in Hematopoiesis throughout Life

Marina Mastelaro de Rezende et al.

CELLS (2020)

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Article Hematology

Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma

Karin Golan et al.

BLOOD (2020)

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Article Cell & Tissue Engineering

Stem cell homing: From physiology to therapeutics

Jane L. Liesveld et al.

STEM CELLS (2020)

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Review Immunology

Influence of KIR and NK Cell Reconstitution in the Outcomes of Hematopoietic Stem Cell Transplantation

Fei Gao et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Editorial Material Hematology

Naive T-cell depletion in stem cell transplantation

Marie Bleakley

BLOOD ADVANCES (2020)

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Review Cell Biology

Fibronectin and Its Receptors in Hematopoiesis

Franziska Wirth et al.

CELLS (2020)

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Review Hematology

Mesenchymal stromal cells in hematopoietic cell transplantation

Andre J. Burnham et al.

BLOOD ADVANCES (2020)

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Article Cell & Tissue Engineering

Thrombopoietin enhances hematopoietic stem and progenitor cell homing by impeding matrix metalloproteinase 9 expression

Yiming Liu et al.

STEM CELLS TRANSLATIONAL MEDICINE (2020)

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Article Oncology

The mechanistic study behind suppression of GVHD while retaining GVL activities by myeloid-derived suppressor cells

Jilu Zhang et al.

LEUKEMIA (2019)

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Article Biochemistry & Molecular Biology

Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation

Cristina Toffalori et al.

NATURE MEDICINE (2019)

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Review Oncology

Oncogenic Deregulation of Cell Adhesion Molecules in Leukemia

Roland Windisch et al.

CANCERS (2019)

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Review Cell Biology

Involvement of CXCR4 in Normal and Abnormal Development

Nanako Kawaguchi et al.

CELLS (2019)

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Review Cell Biology

Hypoxia Pathway Proteins in Normal and Malignant Hematopoiesis

Ben Wielockx et al.

CELLS (2019)

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Article Hematology

Next-generation sequencing-defined minimal residual disease before stem cell transplantation predicts acute myeloid leukemia relapse

Richard D. Press et al.

AMERICAN JOURNAL OF HEMATOLOGY (2019)

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Review Cell & Tissue Engineering

Late Complications of Allogenic Stem Cells Transplantation in Leukaemia

Sharmilla Kanagasundram et al.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2019)

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Article Hematology

The benefit of chronic graft-versus-host disease in patients with acute myeloid leukemia relapsed after allogeneic stem cell transplantation

Ziwei Wang et al.

ANNALS OF HEMATOLOGY (2019)

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Review Hematology

Progress towards improving homing and engraftment of hematopoietic stem cells for clinical transplantation

Xinxin Huang et al.

CURRENT OPINION IN HEMATOLOGY (2019)

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Article Oncology

The effect of asparaginase therapy on methotrexate toxicity and efficacy in children with acute lymphoblastic leukemia

Robin Q. H. Kloos et al.

LEUKEMIA & LYMPHOMA (2019)

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Review Immunology

Graft Engineering and Adoptive Immunotherapy: New Approaches to Promote Immune Tolerance After Hematopoietic Stem Cell Transplantation

Alice Bertaina et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Immunology

B Cell Reconstitution and Influencing Factors After Hematopoietic Stem Cell Transplantation in Children

Nicolaas G. van der Maas et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Cell Biology

Role of Lipid Rafts in Hematopoietic Stem Cells Homing, Mobilization, Hibernation, and Differentiation

Munther Alomari et al.

CELLS (2019)

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Review Hematology

Therapeutic use of regulatory T cells for graft-versus-host disease

Shlomo Elias et al.

BRITISH JOURNAL OF HAEMATOLOGY (2019)

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Article Cell Biology

Osteopontin is An Important Regulative Component of the Fetal Bone Marrow Hematopoietic Stem Cell Niche

Huimin Cao et al.

CELLS (2019)

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Review Hematology

Advances in understanding the pathogenesis of graft-versus-host disease

Robert Zeiser

BRITISH JOURNAL OF HAEMATOLOGY (2019)

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Review Medicine, Research & Experimental

Expanding Therapeutic Opportunities for Hematopoietic Stem Cell Transplantation: T Cell Depletion as a Model for the Targeted Allograft

Christina Cho et al.

ANNUAL REVIEW OF MEDICINE, VOL 70 (2019)

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Review Cell Biology

MLL-Rearranged Acute Leukemia with t(4;11)(q21;q23)-Current Treatment Options. Is There a Role for CAR-T Cell Therapy?

Oliver Britten et al.

CELLS (2019)

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Review Oncology

The Yin and Yang of the Bone Marrow Microenvironment: Pros and Cons of Mesenchymal Stromal Cells in Acute Myeloid Leukemia

Marilena Ciciarello et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Biophysics

Effect of bone marrow CD34+cells and T-cell subsets on clinical outcomes after myeloablative allogeneic hematopoietic cell transplantation

Sagar S. Patel et al.

BONE MARROW TRANSPLANTATION (2019)

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Article Hematology

CTLA-4 polymorphism rs231775: Influence on relapse and survival after allogeneic hematopoietic stem cell transplantation in childhood

Judith Hammrich et al.

EUROPEAN JOURNAL OF HAEMATOLOGY (2019)

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Article Cell & Tissue Engineering

Microvesicles Secreted by Nitric Oxide-Primed Mesenchymal Stromal Cells Boost the Engraftment Potential of Hematopoietic Stem Cells

Sapana Jalnapurkar et al.

STEM CELLS (2019)

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Article Immunology

Individualization of Hematopoietic Stem Cell Transplantation Using Alpha/Beta T-Cell Depletion

Emelie Radestad et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Immunology

Dendritic Cell Regulation of Graft-vs.-Host Disease: Immunostimulation and Tolerance

Hongshuang Yu et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Hematology

Recurrent genetic HLA loss in AML relapsed after matched unrelated allogeneic hematopoietic cell transplantation

Max Jan et al.

BLOOD ADVANCES (2019)

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Review Immunology

Achievement of Tolerance Induction to Prevent Acute Graft-vs.-Host Disease

Govindarajan Thangavelu et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Hematology

Status of Natural Killer Cell Recovery in Day 21 Bone Marrow after Allogeneic Hematopoietic Stem Cell Transplantation Predicts Clinical Outcome

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BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2018)

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Cellular Immunotherapy for Hematologic Malignancies: Beyond Bone Marrow Transplantation

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Increased Coexpression of PD-1, TIGIT, and KLRG-1 on Tumor-Reactive CD8+ T Cells During Relapse after Allogeneic Stem Cell Transplantation

Tim J. A. Hutten et al.

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Rupert Handgretinger et al.

BLOOD (2018)

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Graft failure after allogeneic hematopoietic stem cell transplantation

Zehra Narli Ozdemir et al.

TRANSFUSION AND APHERESIS SCIENCE (2018)

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H2O2/Peroxynitrite-Activated Hydroxamic Acid HDAC Inhibitor Prodrugs Show Antileukemic Activities against AML Cells

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ACS MEDICINAL CHEMISTRY LETTERS (2018)

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Minimal residual disease status predicts outcome of acute myeloid leukaemia patients undergoing T-cell replete haploidentical transplantation. An analysis from the Acute Leukaemia Working Party (ALWP) of the European Society for Blood and Marrow Transplantation (EBMT)

Jonathan Canaani et al.

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Chelsea A. Saito-Reis et al.

MOLECULAR BIOLOGY OF THE CELL (2018)

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Lauren Stern et al.

FRONTIERS IN IMMUNOLOGY (2018)

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SCIENCE TRANSLATIONAL MEDICINE (2018)

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Mesenchymal Stromal Cells: Role in the BM Niche and in the Support of Hematopoietic Stem Cell Transplantation

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Delayed immune reconstitution after allogeneic transplantation increases the risks of mortality and chronic GVHD

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Carolina Martinez-Laperche et al.

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Prophylactic Donor Lymphocyte Infusion (DLI) Followed by Minimal Residual Disease and Graft-versus-Host Disease-Guided Multiple DLIs Could Improve Outcomes after Allogeneic Hematopoietic Stern Cell Transplantation in Patients with Refractory/Relapsed Acute Leukemia

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Selective Depletion of αβ T Cells and B Cells for Human Leukocyte Antigen-Haploidentical Hematopoietic Stem Cell Transplantation. A Three-Year Follow-Up of Procedure Efficiency

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Specially modified stromal and immune microenvironment in injected bone marrow following intrabone transplantation facilitates allogeneic hematopoietic stem cell engraftment

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Infused total nucleated cell dose is a better predictor of transplant outcomes than CD34+ cell number in reduced-intensity mobilized peripheral blood allogeneic hematopoietic cell transplantation

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Impact of Serotherapy on Immune Reconstitution and Survival Outcomes After Stem Cell Transplantations in Children: Thymoglobulin Versus Alemtuzumab

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Granulocyte Colony-stimulating Factor-primed Bone Marrow: An Excellent Stem-cell Source for Transplantation in Acute Myelocytic Leukemia and Chronic Myelocytic Leukemia

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Donor-specific anti-human leukocyte antigen antibodies were associated with primary graft failure after unmanipulated haploidentical blood and marrow transplantation: a prospective study with randomly assigned training and validation sets

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JOURNAL OF MEDICINAL CHEMISTRY (2015)

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Long-term follow-up of haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for the treatment of leukemia Nine Years of Experience at a Single Center

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T cell depletion in paediatric stem cell transplantation

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Article Hematology

Higher Doses of CD34+Progenitors are Associated with Improved Overall Survival Without Increasing GVHD in Reduced Intensity Conditioning Allogeneic Transplant Recipients With Clinically Advanced Disease

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Classifying Cytogenetics in Patients with Acute Myelogenous Leukemia in Complete Remission Undergoing Allogeneic Transplantation: A Center for International Blood and Marrow Transplant Research Study

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BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2012)

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Immune Reconstitution after Double Umbilical Cord Blood Stem Cell Transplantation: Comparison with Unrelated Peripheral Blood Stem Cell Transplantation

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BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2012)

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CURRENT OPINION IN HEMATOLOGY (2012)

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MOLECULAR CANCER THERAPEUTICS (2012)

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TISSUE ANTIGENS (2012)

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BIOCHEMISTRY RESEARCH INTERNATIONAL (2012)

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Pharmacologic modulation of the calcium-sensing receptor enhances hematopoietic stem cell lodgment in the adult bone marrow

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Thymic T-cell development in allogeneic stem cell transplantation

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NK cells mediate reduction of GVHD by inhibiting activated, alloreactive T cells while retaining GVT effects

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BLOOD (2010)

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INTERNATIONAL IMMUNOPHARMACOLOGY (2010)

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Loss of Mismatched HLA in Leukemia after Stem-Cell Transplantation.

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NEW ENGLAND JOURNAL OF MEDICINE (2009)

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IMMUNOTHERAPY (2009)

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BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY (2008)

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Immune reconstitution and implications for immunotherapy following haematopoietic stem cell transplantation

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BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY (2008)

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BONE MARROW TRANSPLANTATION (2008)

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Naive and memory T cells induce different types of graft-versus-host disease

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Annexin II expressed by osteciblasts and endothelial cells regulates stem cell adhesion, homing, and engraftment following transplantation

Younghun Jung et al.

BLOOD (2007)

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Long term disease-free survival in acute leukemia patients recovering with increased γδ T cells after partiallymismatched related donor bone marrow transplantation

K. T. Godder et al.

BONE MARROW TRANSPLANTATION (2007)

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Review Hematology

Risk assessment in haematopoietic stem cell transplantation: Stem cell source

Alvaro Urbano-Ispizua

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY (2007)

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Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men

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Evidence of donor-derived hematologic malignancies after hematopoietic stem cell transplantation

O Sala-Torra et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2006)

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Fast appearance of donor dendritic cells in human skin:: Dynamics of skin and blood dendritic cells after allogeneic hematopoietic cell transplantation

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TRANSPLANTATION (2006)

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Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytes

A Bondanza et al.

BLOOD (2006)

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A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses

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NATURE MEDICINE (2005)

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Reduced-intensity conditioning regimen preserves thymic function in the early period after hematopoietic stem cell transplantation

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EXPERIMENTAL HEMATOLOGY (2005)

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Impact of disease burden at time of allogeneic stem cell transplantation in adults with acute myeloid leukemia and myelodysplastic syndromes

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BONE MARROW TRANSPLANTATION (2005)

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CD34+cell dose and outcome of patients undergoing reduced-intensity-conditioning allogeneic peripheral blood stem cell transplantation

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LEUKEMIA & LYMPHOMA (2005)

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Reconstitution of dendritic and natural killer-cell subsets after allogeneic stem cell transplantation: effects of endogenous flt3 ligand

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BLOOD (2004)

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EXPERIMENTAL HEMATOLOGY (2003)

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Targeting alloreactive donor T-cells to hematopoietic system-restricted minor histocompatibility antigens to dissect graft-versus-leukemia effects from graft-versus-host disease after allogeneic stem cell transplantation

T Mutis

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Immunologic recovery after hematopoietic cell transplantation with nonmyeloablative conditioning

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EXPERIMENTAL HEMATOLOGY (2003)

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Persistence of host dendritic cells after transplantation is associated with graft-versus-host disease

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BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2003)

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Immune reconstitution after haematopoietic cell transplantation in children:: immunophenotype analysis with regard to factors affecting the speed of recovery

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Article Immunology

Factors influencing T-lymphopoiesis after allogeneic hematopoietic cell transplantation

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TRANSPLANTATION (2002)

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Article Hematology

Campath-1G causes rapid depletion of circulating host dendritic cells (DCs) before allogeneic transplantation but does not delay donor DC reconstitution

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BLOOD (2002)

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Allogeneic stem cell transplantation in the treatment of acute myeloid leukemia: An overview of obstacles and opportunities

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