Journal
WORLD JOURNAL OF CLINICAL CASES
Volume 11, Issue 2, Pages 268-291Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.12998/wjcc.v11.i2.268
Keywords
Hematopoietic stem cell; Transplantation; Allogeneic hematopoietic stem cell transplantation; Leukemia; Treatment
Categories
Ask authors/readers for more resources
As an important treatment for acute myeloid leukemia, allogeneic hematopoietic stem cell transplantation (allo-HSCT) has broadened the indications for HSCT and improved long-term survival. However, there are still high risks associated with allo-HSCT, such as hematopoietic reconstitution failure and graft-versus-host disease, which are bottlenecks for further improvements in allo-HSCT efficacy. This paper reviews the progress of relevant research regarding these aspects.
As an important treatment for acute myeloid leukemia, allogeneic hematopoietic stem cell transplantation (allo-HSCT) plays an important role in reducing relapse and improving long-term survival. With rapid advancements in basic research in molecular biology and immunology and with deepening understanding of the biological characteristics of hematopoietic stem cells, allo-HSCT has been widely applied in clinical practice. During allo-HSCT, preconditioning, the donor, and the source of stem cells can be tailored to the patient's conditions, greatly broadening the indications for HSCT, with clear survival benefits. However, the risks associated with allo-HSCT remain high, i.e. hematopoietic reconstitution failure, delayed immune reconstitution, graft-versus-host disease, and post-transplant relapse, which are bottlenecks for further improvements in allo-HSCT efficacy and have become hot topics in the field of HSCT. Other bottlenecks recognized in the current treatment of individuals diagnosed with acute myeloid leukemia and subjected to allo-HSCT include the selection of the most appropriate conditioning regimen and post-transplantation management. In this paper, we reviewed the progress of relevant research regarding these aspects.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available