4.6 Article

Novel Semisynthetic Betulinic Acid-Triazole Hybrids with In Vitro Antiproliferative Potential

Related references

Note: Only part of the references are listed.
Review Chemistry, Medicinal

1,2,3-Triazole hybrids as anticancer agents: A review

Mohammad Mahboob Alam

Summary: Recent advancements in 1,2,3-triazole hybrids have shown promising potential in the development of anticancer agents. These compounds exhibit remarkable biological potential and offer significant opportunities in combating cancer.

ARCHIV DER PHARMAZIE (2022)

Article Biochemistry & Molecular Biology

The C30-Modulation of Betulinic Acid Using 1,2,4-Triazole: A Promising Strategy for Increasing Its Antimelanoma Cytotoxic Potential

Gabriela Nistor et al.

Summary: The study synthesized and tested conjugates of betulinic acid with substituted triazoles as anticancer agents, demonstrating significant cytotoxic effects against melanoma cells while showing selective anticancer activity in normal cells.

MOLECULES (2022)

Article Biochemistry & Molecular Biology

Novel Triterpenic Acid-Benzotriazole Esters Act as Pro-Apoptotic Antimelanoma Agents

Marius Mioc et al.

Summary: The synthesis and biological assessment of benzotriazole esters of pentacyclic triterpenes as potential anticancer agents were reported. These esters demonstrated dose-dependent reductions in cell viability against melanoma cells and inhibition of mitochondrial function.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biochemistry & Molecular Biology

Immortalization of Human Keratinocytes Using the Catalytic Subunit of Telomerase

A. K. Beilin et al.

Summary: A new stable line of human keratinocytes with altered morphology, abnormal chromosomal composition, and expression of keratinocyte markers was obtained. The cells do not exhibit contact inhibition, can be cultured in various media, and have limited stratification ability in vitro. Upon transplantation into nude mice, these cells exhibit tumorigenic properties.

DOKLADY BIOCHEMISTRY AND BIOPHYSICS (2021)

Review Biochemistry & Molecular Biology

Plant-Derived Anticancer Compounds as New Perspectives in Drug Discovery and Alternative Therapy

Cristina Adriana Dehelean et al.

Summary: Despite recent advances in chemically synthetized pharmaceutical agents, nature remains the main source of bioactive molecules. Plant-derived compounds still play a significant role in pharmaceuticals, especially in oncology, as alternatives to traditional chemotherapy.

MOLECULES (2021)

Article Biochemistry & Molecular Biology

Assessment of Betulinic Acid Cytotoxicity and Mitochondrial Metabolism Impairment in a Human Melanoma Cell Line

Dorina Coricovac et al.

Summary: The study indicates that betulinic acid has significant effects on mitochondrial bioenergetics and cellular behavior in melanoma cells, inducing mitochondrial dysfunction and apoptotic cell death, making it a potential strategy for treating melanoma.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

A Review on Preparation of Betulinic Acid and Its Biological Activities

Hanghang Lou et al.

Summary: Betulinic acid, a pentacyclic triterpene, is a compound with a wide range of biological and pharmacological properties, including anti-tumor effects. In addition to extraction from natural resources, methods such as chemical synthesis and microbial biotransformation are now used to prepare betulinic acid to meet the needs of medicine and nutrition.

MOLECULES (2021)

Article Toxicology

Comparative evaluation of HET-CAM and ICE methods for objective assessment of ocular irritation caused by selected pesticide products

Peter Budai et al.

Summary: The study showed a strong correlation between HET-CAM and in vivo tests results, while a weaker correlation was observed between in vivo tests and ICE methods. Therefore, using HET-CAM and ICE tests as part of a battery of tests to reduce animal experimentation is feasible.

TOXICOLOGY IN VITRO (2021)

Review Biochemistry & Molecular Biology

A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications

Nagaraju Kerru et al.

MOLECULES (2020)

Review Integrative & Complementary Medicine

Role of Pentacyclic Triterpenoids in Chemoprevention and Anticancer Treatment: An Overview on Targets and Underling Mechanisms

Mahavir H. Ghante et al.

JOURNAL OF PHARMACOPUNCTURE (2019)

Article Biotechnology & Applied Microbiology

Combination of betulinic acid with diazen-1-ium1,2-diolate nitric oxide moiety donating a novel anticancer candidate

Laiyin Zhang et al.

ONCOTARGETS AND THERAPY (2018)

Article Biochemistry & Molecular Biology

Mitochondria-targeted betulinic and ursolic acid derivatives: synthesis and anticancer activity

Darya A. Nedopekina et al.

MEDCHEMCOMM (2017)

Article Chemistry, Medicinal

A novel triazole derivative of betulinic acid induces extrinsic and intrinsic apoptosis in human leukemia HL-60 cells

Imran Khan et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)

Article Nanoscience & Nanotechnology

Inhibition of lung cancer cells A549 and H460 by curcuminoid extracts and nanoemulsions prepared from Curcuma longa Linnaeus

Hong-Bin Chang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2015)

Article Plant Sciences

Synthesis and cytotoxicity of triterpenoids derived from betulin and betulinic acid via click chemistry

Wei Shi et al.

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2015)

Review Chemistry, Medicinal

Betulinic acid and its derivatives: a patent review (2008-2013)

Rene Csuk

EXPERT OPINION ON THERAPEUTIC PATENTS (2014)

Article Chemistry, Medicinal

Synthesis of 3-O-propargylated betulinic acid and its 1,2,3-triazoles as potential apoptotic agents

Rabiya Majeed et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)

Review Biochemistry & Molecular Biology

Betulinic acid for cancer treatment and prevention

Simone Fulda

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2008)

Article Chemistry, Medicinal

Synthesis of betulonic acid derivatives containing amino-acid fragments

NI Petrenko et al.

CHEMISTRY OF NATURAL COMPOUNDS (2002)