Journal
OPEN FORUM INFECTIOUS DISEASES
Volume 10, Issue 2, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/ofid/ofad030
Keywords
adenovirus; children; digital PCR; immunocompromised; viral load
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Immunocompromised patients are at risk of life-threatening adenoviral infection. A digital polymerase chain reaction assay was developed and evaluated to measure human adenovirus in the respiratory tract, demonstrating that a higher peak viral load is associated with disseminated infection, mechanical ventilation, and death.
Immunocompromised patients can have life-threatening adenoviral infection. Viral load in blood and stool is commonly used to guide antiviral therapy. We developed and evaluated a digital polymerase chain reaction assay to quantify human adenovirus in the respiratory tract and showed that higher peak load correlates with disseminated infection, mechanical ventilation, and death.
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