4.7 Article

Analgesic and Anti-Inflammatory Properties of Ethanolic Extract of Piper vicosanum Leaves

Journal

PHARMACEUTICS
Volume 14, Issue 11, Pages -

Publisher

MDPI
DOI: 10.3390/pharmaceutics14112455

Keywords

Piper vicosanum; inflammatory response; articular inflammation; nociception

Funding

  1. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-CAPES-Brazil
  2. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq [001]
  3. Fundacao de Apoio ao Desenvolvimento do Ensino, Ciencia e Tecnologia do Estado de Mato Grosso do Sul-FUNDECT
  4. Universidade Federal da Grande Dourados-UFGD
  5. Universidade Federal de Mato Grosso do Sul-UFMS
  6. [15/2022]

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This study demonstrated for the first time the antiarthritic and antinociceptive effects of the ethanolic extract of Piper vicosanum leaves, highlighting its potential clinical applications.
Nonclinical trials are important to validate the efficacy and safety of medicinal plants. Scientific toxicological studies with Piper vicosanum Yuncker have showed its safety; however, no studies have indicated the analgesic or antiarthritic potential of the ethanolic extract of P. vicosanum leaves (EEPV). The objective of the present work was to evaluate the antiarthritic and antinociceptive effects of EEPV in experimental mouse models. The oral administration of EEPV (100, 300, and 700 mg/kg) and dexamethasone (1 mg/kg) were performed in carrageenan-induced pleurisy, in formalin and acetic-acid-induced nociception, and in zymosan-induced articular inflammation models in Swiss mice. The EEPV (300 mg/kg) was tested in zymosan-articular inflammation, the complete Freund's adjuvant (CFA) inflammatory model, and in in situ intravitreal microscopy analysis of rolling and adhesion events of leukocytes in the mesenteric microcirculation in mice. EEPV significantly inhibited: (i) nociceptive response at phase 1 and 2, and also in the cold response in the formalin model; (ii) abdominal contortion induced by acetic acid; (iii) mechanical hyperalgesia after 4 and 6 h, knee edema after 6 h, and leukocyte migration in articular inflammation induced by zymosan. All doses of EEPV reduced the leukocyte migration to the inflamed pleural cavity and knee edema 4 h after the zymosan knee injection. The treatment with the EEPV significantly inhibited the CFA-induced edema, mechanical and cold hyperalgesia, and NAG and MPO. The EEPV also significantly inhibited carrageenan-induced leukocyte rolling and adhesion. The present study revealed, for the first time, the antiarthritic and antinociceptive effects of the EEPV.

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