4.7 Article

Structure, Properties, and Release Kinetics of the Polymer/Insect Repellent System Poly (l-Lactic Acid)/Ethyl Butylacetylaminopropionate (PLLA/IR3535)

Journal

PHARMACEUTICS
Volume 14, Issue 11, Pages -

Publisher

MDPI
DOI: 10.3390/pharmaceutics14112381

Keywords

poly (l-lactic acid); ethyl butylacetylaminopropionate (IR3535); plasticization; mechanical properties; repellent release

Funding

  1. European Social Funds (ESF)
  2. Federal State SaxonyAnhalt, Germany
  3. International Graduate School AgriPoly at the Martin Luther University Halle-Wittenberg
  4. Deutsche Forschungsgemeinschaft (DFG) [189853844-TRR 102]

Ask authors/readers for more resources

In this study, the insect repellent IR3535 was added to PLLA to improve its mechanical properties and achieve insect repellency. The two components were miscible at certain composition ratios. The addition of IR3535 reduced the glass transition temperature and elastic modulus of PLLA, acting as a plasticizer.
The insect repellent ethyl butylacetylaminopropionate (IR3535) was used as a functional additive for poly (l-lactic acid) (PLLA) to modify its structure and mechanical properties and achieve insect repellency. PLLA/IR3535 mixtures at various compositions were prepared via melt extrusion. In the analyzed composition range of 0 to 23 m% IR3535, PLLA and IR3535 were miscible at the length scale represented by the glass transition temperature. Addition of IR3535 resulted in a significant decrease in the glass transition temperature of PLLA, as well as in the elastic modulus, indicating its efficiency as a plasticizer. All mixtures were amorphous after extrusion, though PLLA/IR3535 extrudates with an IR3535 content between 18 and 23 m% crystallized during long-term storage at ambient temperature, due to their low glass transition temperature. Quantification of the release of IR3535 into the environment by thermogravimetric analysis at different temperatures between 50 and 100 degrees C allowed the estimation of the evaporation rate at lower temperatures, suggesting an extremely low release rate with a time constant of the order of magnitude of 1-2 years at body temperature.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available