Journal
PHARMACEUTICS
Volume 15, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics15020418
Keywords
polymeric film; diabetes mellitus; skin regeneration; wound healing; sodium alginate; sodium carboxy methyl cellulose; microwave; cross-linking
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This study aimed to develop and optimize a microwave-treated, physically cross-linked polymer blend film for wound healing in diabetic animals. The optimized film formulation showed enhanced physicochemical properties and improved the wound healing process in a diabetic animal model. The results suggest that microwave-treated polymer blend films have the potential to enhance wound healing and promote skin tissue regeneration in diabetic individuals.
This study aimed at developing the microwave-treated, physically cross-linked polymer blend film, optimizing the microwave treatment time, and testing for physicochemical attributes and wound healing potential in diabetic animals. Microwave-treated and untreated films were prepared by the solution casting method and characterized for various attributes required by a wound healing platform. The optimized formulation was tested for skin regeneration potential in the diabetes-induced open-incision animal model. The results indicated that the optimized polymer film formulation (MB-3) has significantly enhanced physicochemical properties such as high moisture adsorption (154.6 +/- 4.23%), decreased the water vapor transmission rate (WVTR) value of (53.0 +/- 2.8 g/m(2)/h) and water vapor permeability (WVP) value (1.74 +/- 0.08 g mm/h/m(2)), delayed erosion (18.69 +/- 4.74%), high water uptake, smooth and homogenous surface morphology, higher tensile strength (56.84 +/- 1.19 MPa), and increased glass transition temperature and enthalpy (through polymer hydrophilic functional groups depicting efficient cross-linking). The in vivo data on day 16 of post-wounding indicated that the wound healing occurred faster with significantly increased percent re-epithelialization and enhanced collagen deposition with optimized MB-3 film application compared with the untreated group. The study concluded that the microwave-treated polymer blend films have sufficiently enhanced physical properties, making them an effective candidate for ameliorating the diabetic wound healing process and hastening skin tissue regeneration.
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