Journal
PHARMACEUTICS
Volume 14, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics14122784
Keywords
microemulsions; finasteride; poloxamer 124; skin penetration pathway; confocal laser scanning microscopy
Categories
Funding
- National Research Council of Thailand
- Faculty of Pharmaceutical Sciences, Burapha University
- Research and Development Fund Burapha University
- [N42A650551]
- [8/2565]
- [11/2565]
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This study aimed to develop microemulsions using poloxamer 124 as a surfactant to improve the skin penetration of finasteride. The microemulsions were found to significantly increase the skin penetration of finasteride, mainly through the hair follicle pathway.
This study aimed to develop microemulsions using poloxamer 124 as a surfactant to improve the skin penetration of finasteride and to investigate the skin penetration pathways of these microemulsions by colocalization techniques using confocal laser scanning microscopy (CLSM). The prepared finasteride-loaded microemulsions had average particle sizes ranging from 80.09 to 136.97 nm with particle size distributions within acceptable ranges and exhibited negative surface charges. The obtained microemulsions could significantly increase the skin penetration of finasteride compared to a finasteride solution. According to the skin penetration pathway evaluation conducted with CLSM, the microemulsions were hair follicle-targeted formulations due to penetration via the transfollicular pathway as a major skin penetration pathway. Additionally, this study found that the microemulsions also penetrated via the intercluster pathway more than via the intercellular pathway and transcellular pathway. The intercluster pathway, intercellular pathway, and transcellular pathway were considered only minor pathways.
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