☆ 4.7 Review

3D Printing Technologies in Personalized Medicine, Nanomedicines, and Biopharmaceuticals

PHARMACEUTICS (2023)

Related references

Note: Only part of the references are listed.

Review Medicine, Research & Experimental

Bioprinting: From Technique to Application in Tissue Engineering and Regenerative Medicine

Thais Vieira de Souza et al.

Summary: Bioprinting, a promising technique in regenerative medicine and tissue engineering, has gained significant interest for its potential in printing functional biological tissues. Hydrogels, especially those based on natural polymers, are explored due to their biocompatibility and ability to mimic the extracellular matrix. Bioinks, ink formulations that allow the printing of living cells, require specific biochemical and physical stimuli to maintain cell viability and guide cell behavior. This review discusses the theoretical and practical aspects of bioprinting, current methods, and future perspectives.

CURRENT MOLECULAR MEDICINE (2023)

Add to Collection

Article Pharmacology & Pharmacy

Development of 3D printed drug-eluting contact lenses

Youssra Moustafa Gadelkareem Mohamdeen et al.

Summary: This study introduces 3D printing technology for the design and fabrication of drug-eluting contact lenses for the treatment of glaucoma. By using hot melt extrusion and fusion deposition modeling, printable filaments loaded with timolol maleate were successfully produced. The study demonstrates the feasibility of using 3D printing to manufacture contact lenses with controlled drug release.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2022)

Add to Collection

Review Polymer Science

Peptides as 3D printable feedstocks: Design strategies and emerging applications

Robert D. Murphy et al.

Summary: Peptide hydrogels are critical building blocks for various scientific applications due to their high water capacity, tunable mechanical properties, and modular synthetic design. They are particularly interesting in the biomedical field due to their biomimetic structure and biocompatibility, making them suitable for 3D printing matrices. This review discusses two strategies for preparing peptide hydrogels using solid-phase peptide synthesis and N-carboxyanhydride ring opening polymerization, and explores their applicability in 3D printing and potential research directions.

PROGRESS IN POLYMER SCIENCE (2022)

Add to Collection

Review Medical Informatics

Quality of FDM 3D Printed Medicines for Pediatrics: Considerations for Formulation Development, Filament Extrusion, Printing Process and Printer Design

Julian Quodbach et al.

Summary: 3D printing technology enables dose individualization for pediatric medicines and precision medicine approach, but there is a need for improvement in understanding critical quality attributes and process parameters. To ensure patient health and safety, cleaning and process validation should be established, along with adequate analytical methods for in-process control of intermediates.

THERAPEUTIC INNOVATION & REGULATORY SCIENCE (2022)

Add to Collection

Review Biotechnology & Applied Microbiology

Review on Multicomponent Hydrogel Bioinks Based on Natural Biomaterials for Bioprinting 3D Liver Tissues

Daekeun Kim et al.

Summary: Multicomponent bioinks have shown great potential in 3D bioprinting of in vitro liver tissue models. By improving the mechanical properties of the printed tissue constructs and cell functionality, multicomponent bioinks can enhance cellular responses and functions in drug screening, liver disease, and liver regenerative medicine.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

Add to Collection

Article Nanoscience & Nanotechnology

3D-Printed Porous Scaffolds of Hydrogels Modified with TGF-β1 Binding Peptides to Promote In Vivo Cartilage Regeneration and Animal Gait Restoration

Xiaoquan Ding et al.

Summary: In this study, a bilayered porous scaffold with bioactive peptides was constructed for osteochondral repair. The scaffold showed promising therapeutic efficacy in promoting tissue regeneration and restoring animal gait behavior.

ACS APPLIED MATERIALS & INTERFACES (2022)

Add to Collection

Article Cell & Tissue Engineering

Stem Cell-Seeded 3D-Printed Scaffolds Combined with Self-Assembling Peptides for Bone Defect Repair

Haixia Xu et al.

Summary: The study successfully treated calvarial defects by combining BMSC-seeded 3D-printed PCL with SAPs, promoting bone regeneration and neovascularization. Results showed that PCL/BMSC/SAP implants significantly enhanced bone and blood vessel formation, offering an effective approach for treating bone defects.

TISSUE ENGINEERING PART A (2022)

Add to Collection

Review Nanoscience & Nanotechnology

Ultrasmall superparamagnetic iron oxide nanoparticles: A next generation contrast agent for magnetic resonance imaging

Can Chen et al.

Summary: USPIO nanoparticles, with their excellent MRI performance and remarkable biosafety profile, have shown considerable applications in developing T-1 contrast agents and T-2/T-1 switchable contrast agents, and have been widely used in the diagnosis of vascular pathological changes, inflammations, and malignant tumors.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2022)

Add to Collection

Article Pharmacology & Pharmacy

Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines

Ihatanderson A. Silva et al.

Summary: This study proposes a new protocol for preformulation studies of three-dimensional printed medicines, aiming to address the stability issue caused by high temperatures during manufacturing. The results indicate that drug-polymer interactions can preserve the chemical stability of certain drug-polymer combinations, while others show signs of instability and chemical decomposition.

JOURNAL OF PHARMACEUTICAL ANALYSIS (2022)

Add to Collection

Article Pharmacology & Pharmacy

3D Printed Mini-Floating-Polypill for Parkinson's Disease: Combination of Levodopa, Benserazide, and Pramipexole in Various Dosing for Personalized Therapy

Hellen Windolf et al.

Summary: Treating Parkinson's disease is challenging, and personalized therapy is crucial due to specific requirements of drug therapy. This study utilized 3D printing to create personalized medication, including both rapid and prolonged drug release formulations, to meet the varying drug release needs. This provides a more personalized and effective treatment option for patients with Parkinson's disease.

PHARMACEUTICS (2022)

Add to Collection

Article Chemistry, Medicinal

Development of Advanced 3D-Printed Solid Dosage Pediatric Formulations for HIV Treatment

Azizah M. Malebari et al.

Summary: The combination of lopinavir/ritonavir is commonly used for treating pediatric HIV-infected children. However, challenges arise in implementing this therapy due to storage requirements, high alcohol content, and unpalatability of the medication. This study demonstrated the feasibility of using 3D printing to manufacture personalized pediatric HIV dosage forms.

PHARMACEUTICALS (2022)

Add to Collection

Article Pharmacology & Pharmacy

Redispersible 3D printed nanomedicines: An original application of the semisolid extrusion technique

Thayse Viana de Oliveira et al.

Summary: Semisolid extrusion is a 3D printing technique that can produce objects from gels or pastes without the need for a light source. In this study, the suitability of semisolid extrusion for producing 3D printed oral solid forms containing drug-loaded polymeric nanocapsules was evaluated. The results showed successful printing of homogeneous solid forms with a specific weight and polyphenol content, and the nanocarriers were recovered.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

Add to Collection

Article Engineering, Biomedical

In vivo study of dual functionalized mussel-derived bioactive peptides promoting 3D-printed porous Ti6Al4V scaffolds for repair of rabbit femoral defects

Run Ze Zhang et al.

Summary: By incorporating designed peptide conjugates onto 3D printed porous titanium alloy scaffolds, the osseointegration and mechanical stability can be significantly enhanced, addressing the weak bond between titanium alloy implants and bone tissue.

JOURNAL OF BIOMATERIALS APPLICATIONS (2022)

Add to Collection

Article Dentistry, Oral Surgery & Medicine

Surgical guides for flapless dental implant placement and immediate definitive prosthesis installation by using selective laser melting and sintering for 3D metal and polymer printing: A clinical report

Giovanni de A.P. Di Giacomo et al.

JOURNAL OF PROSTHETIC DENTISTRY (2022)

Add to Collection

Editorial Material Biochemical Research Methods

Modeling multi-organ systems on a chip

Nina Vogt

Summary: Engineered tissues can be connected by vascular flow in a multi-organ chip, recapitulating the complexities of human physiology.

NATURE METHODS (2022)

Add to Collection

Article Cell Biology

A human kidney and liver organoid-based multi-organ-on-a-chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell-derived extracellular vesicles

Vivian V. T. Nguyen et al.

Summary: This study used an in vitro multi-organ-on-a-chip model to investigate the effects of MSC-derived sEVs on kidney and liver organoids. The results showed that sEVs stimulated recovery of injured renal epithelium and accumulated in both injured kidney cells and intact liver organoids. This research method provides insights into the mechanism of action and potential side effects of sEVs.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

Add to Collection

Article Pharmacology & Pharmacy

Preferences of Healthcare Professionals on 3D-Printed Tablets: A Pilot Study

Odelia Goh et al.

Summary: An inaugural study was conducted to understand the perceptions of healthcare professionals in Singapore on the potential benefits of 3D printing. The majority of respondents viewed 3D printed oral dosage forms favorably, and over 60% were willing to prescribe 3D printed tablets to patients. Concerns were mainly focused on formulation considerations, manufacturing processes, and administrative issues.

PHARMACEUTICS (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Bioinspired Protein/Peptide Loaded 3D Printed PLGA Scaffold Promotes Bone Regeneration

Xiaoliang Song et al.

Summary: This study investigated the effect of 3D-printed PLGA scaffolds combined with GFOGER and BMP-9 on the repair of large bone defects. The results showed that the modified scaffold enhanced new bone mineral deposition and density, promoting uniform trabeculae formation and new bone regeneration. This research provides important guidance for the application of bone tissue engineering.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

A multi-organ-on-chip to recapitulate the infiltration and the cytotoxic activity of circulating NK cells in 3D matrix-based tumor model

Monica Marzagalli et al.

Summary: The success of immunotherapeutic approaches depends on the interaction between immune cells and cancer cells. Conventional cell cultures and animal models cannot fully represent the complexity of the tumor microenvironment and the human immune system. Therefore, it is crucial to develop reliable and predictive preclinical models for screening immunotherapeutic approaches. This study presents an organ-on-chip (OOC)-based approach that can mimic the migration of natural killer (NK) cells, infiltration into a 3D tumor matrix, and activation against neuroblastoma cancer cells in a fluid-dynamic environment. The proposed immune-tumor OOC-based model shows promise in faithfully replicating human pathology and effectively testing immunotherapies, potentially in a personalized perspective.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

Add to Collection

Review Chemistry, Analytical

3D and 4D Printing in the Fight against Breast Cancer

Sofia Moroni et al.

Summary: Breast cancer, the second most common cancer worldwide, requires a patient-centered approach due to its heterogeneity. 3D printing and 4D printing technologies show potential in breast cancer management. This review provides an overview of current approaches, discusses the benefits and limitations of these technologies, and outlines future perspectives and challenges.

BIOSENSORS-BASEL (2022)

Add to Collection

Review Pharmacology & Pharmacy

Continuous Manufacturing and Molecular Modeling of Pharmaceutical Amorphous Solid Dispersions

Amritha G. Nambiar et al.

Summary: Amorphous solid dispersions effectively improve the solubility and oral bioavailability of poorly water-soluble drugs. This review discusses recent advancements in utilizing amorphous solid dispersions to enhance dissolution and bioavailability, as well as the challenges faced in terms of stability and scale-up. The role of process analytical technology (PAT) and computational modeling techniques in supporting continuous manufacturing is highlighted.

AAPS PHARMSCITECH (2022)

Add to Collection

Article Pharmacology & Pharmacy

A microfluidic approach to fabricate sucrose decorated liposomes with increased uptake in breast cancer cells

Shiva Khorshid et al.

Summary: The development of targeted drug delivery systems is urgently needed to reduce side effects and increase drug efficacy. This study presents a new strategy to easily manufacture sucrose decorated liposomes using sucrose stearate and a scalable microfluidic approach. The sucrose decorated liposomes loaded with berberine hydrochloride showed promising results in inhibiting triple-negative breast cancer cells.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2022)

Add to Collection

Article Chemistry, Multidisciplinary

On-demand delivery of protein drug from 3D-printed implants

Dongyoon Kim et al.

Summary: This study constructed 3D-printed multiunit implants for remote light-controlled protein drug delivery. The implants were designed to be 3D printed using a matrix of polycaprolactone, lauric acid, and melanin. Insulin was loaded into each unit of the implant, and near infrared light (NIR) was used to trigger controlled release of insulin. The results suggest that this 3D printing technology can provide convenient treatment for diabetes through external NIR irradiation, avoiding the pain and discomfort of repeated insulin injections.

JOURNAL OF CONTROLLED RELEASE (2022)

Add to Collection

Article Chemistry, Multidisciplinary

3D Printed Composite Scaffolds of GelMA and Hydroxyapatite Nanopowders Doped with Mg/Zn Ions to Evaluate the Expression of Genes and Proteins of Osteogenic Markers

Rebeca Leu Alexa et al.

Summary: This study developed a scaffold material for tissue engineering using nanocomposite materials and 3D bioprinting technology, and evaluated its properties through various experimental methods. The results suggest a positive effect of magnesium and zinc on osteogenic differentiation.

NANOMATERIALS (2022)

Add to Collection

Review Pharmacology & Pharmacy

Microfluidic Manufacture of Lipid-Based Nanomedicines

Karim Osouli-Bostanabad et al.

Summary: Nanoparticulate technologies have revolutionized drug delivery, but their manufacture remains immature. Lipid-based nanomedicines are the most widely approved, but their current manufacturing methods are complex and not easily scalable. The emergence of microfluidic strategies has introduced a paradigm shift in the manufacturing of lipid-based nanomedicines, allowing for tunable and reproducible structure.

PHARMACEUTICS (2022)

Add to Collection

Review Pharmacology & Pharmacy

Drug Stability: ICH versus Accelerated Predictive Stability Studies

Olga Gonzalez-Gonzalez et al.

Summary: The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) and the World Health Organization (WHO) have provided guidelines to unify stability standards for the European Union, Japan, and the United States. These guidelines aim to facilitate mutual acceptance of stability data for regulatory registration. ICH stability studies involve testing drug substances under various storage conditions to assess their thermal stability and sensitivity to moisture. Accelerated Predictive Stability (APS) studies have emerged as a more efficient approach to predict long-term stability by combining extreme conditions over a shorter period of time.

PHARMACEUTICS (2022)

Add to Collection

Article Pharmacology & Pharmacy

Solid Nanomedicines of Nifurtimox and Benznidazole for the Oral Treatment of Chagas Disease

Miriam Rolon et al.

Summary: Chagas disease is a parasitic zoonosis that is endemic in Central and South America, and current treatment options are limited. This study presents a new drug delivery system that allows for scalable combined formulations and can be easily converted to oral solid dosage form. The experimental results demonstrate promising efficacy of this new therapy.

PHARMACEUTICS (2022)

Add to Collection

Review Pharmacology & Pharmacy

3D Bioprinted Chitosan-Based Hydrogel Scaffolds in Tissue Engineering and Localised Drug Delivery

Maria Lazaridou et al.

Summary: Bioprinting is a promising technology for developing functional tissue constructs and controlled drug delivery systems. Chitosan, a natural polysaccharide, is an attractive bioink for tissue regeneration and restoration.

PHARMACEUTICS (2022)

Add to Collection

Article Pharmacology & Pharmacy

Formulation of a 3D Printed Biopharmaceutical: The Development of an Alkaline Phosphatase Containing Tablet with Ileo-Colonic Release Profile to Treat Ulcerative Colitis

Khanh T. T. Nguyen et al.

Summary: This study investigated the use of powder bed printing to produce tablets containing alkaline phosphatase for the treatment of ulcerative colitis. The study also examined the coating of these tablets to achieve ileo-colonic targeting. The results showed that line spacing was a critical factor affecting tablet physical properties, with increasing line spacing resulting in higher porosity. In vitro release experiments demonstrated successful ileo-colonic release. The tablets are the first to incorporate biopharmaceuticals in powder bed printed form and achieve ileo-colonic targeting, making them potentially suitable for personalized treatment of ulcerative colitis.

PHARMACEUTICS (2022)

Add to Collection

Review Engineering, Biomedical

Zinc-Based Biodegradable Materials for Orthopaedic Internal Fixation

Yang Liu et al.

Summary: Traditional inert materials used in internal fixation have caused complications and usually need to be removed with secondary surgeries. Biodegradable materials like magnesium, iron, and zinc alloys offer a new solution. Zinc alloys have comparable mechanical properties to traditional metals and a moderate degradation rate, making them a good candidate for internal fixation materials. Research on zinc-based biodegradable materials, including in vitro and in vivo studies, is progressing towards clinical applications in fracture fixation.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2022)

Add to Collection

Article Pharmacology & Pharmacy

Preformulation Studies to Guide the Production of Medicines by Fused Deposition Modeling 3D Printing

Ludmila A. G. Pinho et al.

Summary: The study assessed the use of a tailored preformulation protocol for the development of medicines by FDM 3D printing, highlighting the potential impact of material incompatibilities on the performance of drug products.

AAPS PHARMSCITECH (2021)

Add to Collection

Review Engineering, Multidisciplinary

3D printing for polymer/particle-based processing: A review

Weiheng Xu et al.

Summary: The 3D printing technology, also known as additive manufacturing, has great potential in manufacturing but requires further research to develop new mechanisms for multi-material manufacturing. Materials with unique properties, such as particles, can find broad applications in various fields. This review provides an overview of different 3D printing mechanisms and summarizes the processing parameters, advantages, disadvantages, and future challenges.

COMPOSITES PART B-ENGINEERING (2021)

Add to Collection

Article Pharmacology & Pharmacy

Pressure-assisted microsyringe 3D printing of oral films based on pullulan and hydroxypropyl methylcellulose

M. Elbadawi et al.

Summary: The study utilized 3D printing to produce hybrid film structures of pullulan and hydroxypropyl methylcellulose loaded with caffeine as a model drug. It was found that the addition of hydroxypropyl methylcellulose increased the mechanical properties of the pullulan films. Additionally, the spatial orientation of the hybrid films was explored to maximize their mechanical properties.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Add to Collection

Article Materials Science, Biomaterials

Stereolithography (SLA) 3D printing of a bladder device for intravesical drug delivery

Xiaoyan Xu et al.

Summary: This study introduces the use of stereolithography (SLA) 3D printing for manufacturing novel indwelling bladder devices that allow extended and localized delivery of lidocaine hydrochloride. The devices showed good blood compatibility, resistance to external forces, and sustained drug release capabilities. This new approach offers potential for personalized and revolutionary intravesical drug delivery for bladder diseases.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Add to Collection

Article Materials Science, Biomaterials

3D Printed Contact Lenses

Fahad Alam et al.

Summary: The study demonstrated the fabrication of personalized smart contact lenses using additive manufacturing, which have built-in sensing capabilities through microchannels and holographic laser ablation. 3D printing allows for customized ophthalmic devices and integration with optical sensors.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

Add to Collection

Review Chemistry, Multidisciplinary

3D Printing and Nanotechnology: A Multiscale Alliance in Personalized Medicine

Juliana dos Santos et al.

Summary: The combination of 3D printing and nanotechnology has shown significant progress in the pharmaceutical and medical field, particularly in terms of innovation and multifunctionality of medical products. Various scientific studies have demonstrated the potential of this alliance, with breakthroughs expected in areas such as cell growth, drug delivery, and antimicrobial applications.

ADVANCED FUNCTIONAL MATERIALS (2021)

Add to Collection

Article Materials Science, Biomaterials

Multifunctional 3D printed porous GelMA/xanthan gum based dressing with biofilm control and wound healing activity

Zhenming Yang et al.

Summary: The 3D printed antibacterial wound dressing with N-halamine/TiO2 showed excellent water uptake efficiency and antibacterial activity against Escherichia coli and Staphylococcus aureus, while inhibiting bacterial biofilm formation. In vivo data demonstrated accelerated wound healing in a mouse model, indicating the potential of these dressings for wound treatment.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Add to Collection

Review Pharmacology & Pharmacy

3D printed microneedles for transdermal drug delivery: A brief review of two decades

Nafiseh Elahpour et al.

Summary: Microneedle technology has great potential in controlled drug delivery, with 3D printing providing more flexibility in manufacturing methods. The review focuses on the successes of 3D printed microneedle-based patches and the state of the art in long-acting microneedles.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Add to Collection

Article Pharmacology & Pharmacy

Microfluidics for nanomedicines manufacturing: An affordable and low-cost 3D printing approach

Mattia Tiboni et al.

Summary: Innovative lab-on-a-chip technology microfluidics has become popular in the pharmaceutical field for producing nanomedicines in a scalable way. However, new users face barriers such as access to expensive equipment and fabrication expertise. 3D printing, particularly fused deposition modeling, offers a promising solution to overcoming these barriers and expanding the realm of microfluidics. By developing polypropylene-based microfluidic chips through this technology, affordable and effective production of nanomedicines can be achieved with tunable characteristics and efficient drug loading.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Add to Collection

Article Pharmacology & Pharmacy

3D printed spherical mini-tablets: Geometry versus composition effects in controlling dissolution from personalised solid dosage forms

Sejad Ayyoubi et al.

Summary: Oral dosage forms are widely used but can cause adverse effects due to standardized mass produced solid dosage forms. 3D printing allows for personalized medicine, as shown in the study focusing on hypertensive patients using nifedipine. The drug dissolution is more impacted by composition rather than geometry and surface area.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Add to Collection

Article Pharmacology & Pharmacy

3D printing of patient-tailored SNEDDS-based suppositories of lidocaine

Aikaterini-Theodora Chatzitaki et al.

Summary: Personalized drug delivery systems using 3D printing technology have the potential to counterbalance pharmacological effects. In this study, pressure-assisted microsyringes were utilized to fabricate lidocaine-loaded suppositories, with in vitro dissolution profiles showing delayed lidocaine release.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

Add to Collection

Review Chemistry, Multidisciplinary

3D Printing in Development of Nanomedicines

Keerti Jain et al.

Summary: Three-dimensional (3D) printing is advancing in the manufacturing of nanomedicines for personalized treatment, using a variety of natural biomaterials and engineered polymers. This technology has the potential to revolutionize biomedical applications and contribute to precision medicine.

NANOMATERIALS (2021)

Add to Collection

Article Pharmacology & Pharmacy

Preparation of High-Drug-Loaded Clarithromycin Gastric-Floating Sustained-Release Tablets Using 3D Printing

Peihong Chen et al.

Summary: The high-drug-loaded sustained-release gastric-floating clarithromycin tablets were successfully manufactured using SSE-based 3D printing, achieving sustained release times of 8 hours and 12 hours.

AAPS PHARMSCITECH (2021)

Add to Collection

Article Pharmacology & Pharmacy

A 3D-Printed Polymer-Lipid-Hybrid Tablet towards the Development of Bespoke SMEDDS Formulations

Bryce W. Barber et al.

Summary: This study advances the field of 3D-printed solid lipid formulations by introducing a 3D-printed dissolvable polymer scaffold to compartmentalize different drugs in different lipid formulations within a single dosage form. The dispersion and drug release are predictably dependent on the exposed surface area-to-volume ratio (SA:V) and independent of the drug, offering opportunities for developing new dose forms with advantages in a polypharmacy context.

PHARMACEUTICS (2021)

Add to Collection

Article Pharmacology & Pharmacy

Engineering 3D Printed Microfluidic Chips for the Fabrication of Nanomedicines

Aytug Kara et al.

Summary: The article introduces the method and advantages of manufacturing nanomedicines using 3D printed microfluidic chips, and demonstrates the experimental results of fabricating polymeric nanoparticles. The research shows that nanoparticles manufactured using SLA technology have smaller particle sizes and smoother channel surfaces.

PHARMACEUTICS (2021)

Add to Collection

Article Pharmacology & Pharmacy

Understanding Direct Powder Extrusion for Fabrication of 3D Printed Personalised Medicines: A Case Study for Nifedipine Minitablets

Sergio A. Sanchez-Guirales et al.

Summary: Fuse deposition modelling (FDM) is a novel technology for manufacturing 3D printed medicines, but the fabrication of filaments can be a rate-limiting step. Direct powder extrusion overcomes this difficulty, allowing the manufacturing of solid dosage forms in a single step for the treatment of hypertension and other diseases requiring polypharmacy.

PHARMACEUTICS (2021)

Add to Collection

Article Pharmacology & Pharmacy

Influence of Print Settings on the Critical Quality Attributes of Extrusion-Based 3D-Printed Caplets: A Quality-by-Design Approach

Silke Henry et al.

Summary: Extrusion-based 3D-printing is a cost-effective method for producing tailored precision medicines, but the impact of print parameters on critical quality attributes is not well understood. This study provides practical guidelines for medical 3D-printing using a design-of-experiments approach. By investigating five print parameters, the study revealed their effects on the mechanical properties of printed items.

PHARMACEUTICS (2021)

Add to Collection

Review Chemistry, Multidisciplinary

Semi-solid extrusion 3D printing in drug delivery and biomedicine: Personalised solutions for healthcare challenges

Iria Seoane-Viano et al.

Summary: SSE 3D printing is a low-temperature printing technology suitable for drug delivery and biomedical applications, creating objects of any size and shape by sequentially depositing layers of gel or paste.

JOURNAL OF CONTROLLED RELEASE (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

3D Printed Integrated Multi-Layer Microfluidic Chips for Ultra-High Volumetric Throughput Nanoliposome Preparation

Han Shan et al.

Summary: This study presents a method for ultra-high volumetric throughput nanoliposome preparation using 3D printed microfluidic chips. By adopting a three-layer layout for microchannels, the microfluidic chip achieved a total flow rate up to 474 ml min(-1) and controlled the liposome size to be as small as 80 nm. The experimental results demonstrate the great potential of the 3D printed integrated microfluidic chip in targeting drug delivery systems.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Manufacturing of 3D-Printed Microfluidic Devices for the Synthesis of Drug-Loaded Liposomal Formulations

Giulia Ballacchino et al.

Summary: Microfluidic technique is a promising tool for producing stable and monodispersed nanoparticles, with a focus on liposome production in this study. The use of 3D printing for microfluidic device production has provided a revolutionary, low-cost option. The study evaluated the impact of microfluidic parameters, chip manufacturing, material, and channel design on liposomal characteristics, and demonstrated enhanced encapsulation efficiency of curcumin-loaded liposomes produced by microfluidics.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Pharmacology & Pharmacy

3D printed hollow microneedles array using stereolithography for efficient transdermal delivery of rifampicin

Vivek Yadav et al.

Summary: A 3D printed assembly of hollow microneedles, designed and manufactured using stereolithography technology, was used for transdermal delivery of high molecular weight antibiotics. The microneedles were designed with sub-apical holes for improved mechanical strength, and were characterized for quality and uniformity. Ex vivo and in vivo experiments confirmed the efficient penetration and desired bioavailability of the antibiotic.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Add to Collection

Article Chemistry, Medicinal

3D Printing and Dissolution Testing of Novel Capsule Shells for Use in Delivering Acetaminophen

Shantanu G. Gaurkhede et al.

Summary: Individualized drug delivery is crucial for enhancing drug efficacy and safety. 3D printed capsules offer great potential for personalized treatments, with the ability to slow down drug release and reduce side effects. Non-animal-based materials, such as PVA and HPMC blends, show promise as alternatives to traditional gelatin capsules.

JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

Add to Collection

Review Pharmacology & Pharmacy

Mimicking bone microenvironment: 2D and 3D in vitro models of human osteoblasts

I Yuste et al.

Summary: Understanding the biology and behavior of human osteoblasts in vitro is crucial for developing research models that replicate bone structure and interactions accurately. Mimicking the bone microenvironment is challenging yet essential for clinical translation of novel medicines. Advanced technologies like 3D bioprinting and microfluidics bridge the gap between in vitro and in vivo models.

PHARMACOLOGICAL RESEARCH (2021)

Add to Collection

Article Pharmacology & Pharmacy

3D Printing of Dapagliflozin Containing Self-Nanoemulsifying Tablets: Formulation Design and In Vitro Characterization

Mohammed S. Algahtani et al.

Summary: This study explores 3D printing for designing an immediate-release oral solid dosage form of a poorly water-soluble drug using a self-nanoemulsifying tablet formulation. The PAM-based 3D printing technique successfully produced a drug-loaded self-nanoemulsifying tablet with rapid drug release characteristics.

PHARMACEUTICS (2021)

Add to Collection

Review Pharmacology & Pharmacy

Selective Laser Sintering (SLS), a New Chapter in the Production of Solid Oral Forms (SOFs) by 3D Printing

Yanis A. Gueche et al.

Summary: 3D printing technology, particularly selective laser sintering (SLS), offers great potential in pharmaceutical manufacturing for personalized medicine. The modulation of printed material porosity is a key feature of SLS for pharmaceutical applications. Despite challenges in drug stability and powder recycling, collaboration between pharmaceutical industries and compounding pharmacies could help overcome these hurdles and further the deployment of SLS in clinical practice.

PHARMACEUTICS (2021)

Add to Collection

Article Pharmacology & Pharmacy

Direct Powder Extrusion 3D Printing of Praziquantel to Overcome Neglected Disease Formulation Challenges in Paediatric Populations

Janine Boniatti et al.

Summary: This study demonstrates the successful preparation of pediatric Printlets(TM) of praziquantel using DPE 3DP technology, addressing the lack of suitable pediatric formulations for schistosomiasis treatment. The technology showed excellent taste masking capabilities and significantly increased praziquantel release, potentially overcoming the main formulation hurdles of the drug.

PHARMACEUTICS (2021)

Add to Collection

Article Pharmacology & Pharmacy

Direct Powder Extrusion of Paracetamol Loaded Mixtures for 3D Printed Pharmaceutics for Personalized Medicine via Low Temperature Thermal Processing

Xabier Mendibil et al.

Summary: Three-dimensional printed drug development using potato starch and hydroxypropyl cellulose mixtures loaded with paracetamol has shown potential for personalized medicine, with drug recovery highly dependent on initial moisture levels and slower drug release observed in aged samples.

PHARMACEUTICS (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Galenic Lab-on-a-Chip concept for lipid nanocapsules production

Nicolas Rolley et al.

Summary: This study focuses on continuous production of drug delivery systems using microfluidics for high reproducibility and controlled particle size distributions. GALECHIP concept is proposed for formulating nanomedicines like LNCs, with chips manufactured using 3D printing and DRIE technologies. The transparent Si/Glass chip is used for small angle X-ray scattering analysis of LNC formulation. Discussions revolve around costs and advantages of the technologies in a GALECHIP point of view.

NANOSCALE (2021)

Add to Collection

Review Engineering, Biomedical

3D Bioprinting at the Frontier of Regenerative Medicine, Pharmaceutical, and Food Industries

Qasem Ramadan et al.

Summary: 3D printing technology has driven a significant paradigm shift in various industrial domains, with particular success in biomedical and healthcare applications. The integration of 3D printing into tissue engineering has led to innovative solutions, although there are still capabilities and limitations that need to be addressed.

FRONTIERS IN MEDICAL TECHNOLOGY (2021)

Add to Collection

Review Pharmacology & Pharmacy

Transferosomes as nanocarriers for drugs across the skin: Quality by design from lab to industrial scale

Raquel Fernandez-Garcia et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Add to Collection

Article Pharmacology & Pharmacy

3D printing of multilayered orodispersible films with in-process drying

Jan Elbl et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Add to Collection

Article Engineering, Biomedical

Design of a patient-specific mandible reconstruction implant with dental prosthesis for metal 3D printing using integrated weighted topology optimization and finite element analysis

Chia-Hsuan Li et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2020)

Add to Collection

Article Materials Science, Biomaterials

3D printed microneedles for anticancer therapy of skin tumours

Md Jasim Uddin et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

Add to Collection

Article Chemistry, Physical

Optimization of the 3D Printing Parameters for Tensile Properties of Specimens Produced by Fused Filament Fabrication of 17-4PH Stainless Steel

Damir Godec et al.

MATERIALS (2020)

Add to Collection

Article Pharmacology & Pharmacy

3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients

Atheer Awad et al.

PHARMACEUTICS (2020)

Add to Collection

Article Pharmacology & Pharmacy

Printability of External and Internal Structures Based on Digital Light Processing 3D Printing Technique

Yan Yang et al.

PHARMACEUTICS (2020)

Add to Collection

Review Pharmacology & Pharmacy

Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials-Process Perspective

Mohammad A. Azad et al.

PHARMACEUTICS (2020)

Add to Collection

Article Obstetrics & Gynecology

A multi-organ-chip co-culture of liver and testis equivalents: a first step toward a systemic male reprotoxicity model

Y. Baert et al.

HUMAN REPRODUCTION (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Effects of Filament Extrusion, 3D Printing and Hot-Pressing on Electrical and Tensile Properties of Poly(Lactic) Acid Composites Filled with Carbon Nanotubes and Graphene

Giovanni Spinelli et al.

NANOMATERIALS (2020)

Add to Collection

Editorial Material Chemistry, Physical

Special Issue: Ti-Based Biomaterials: Synthesis, Properties and Applications

Jaroslaw Jakubowicz

MATERIALS (2020)

Add to Collection

Article Pharmacology & Pharmacy

Personalised 3D Printed Medicines: Optimising Material Properties for Successful Passive Diffusion Loading of Filaments for Fused Deposition Modelling of Solid Dosage Forms

Jose R. Cerda et al.

PHARMACEUTICS (2020)

Add to Collection

Article Pharmacology & Pharmacy

3D-printed microfluidic chip for the preparation of glycyrrhetinic acid-loaded ethanolic liposomes

Mattia Tiboni et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Add to Collection

Article Pharmacology & Pharmacy

Stereolithography (SLA) 3D printing of ascorbic acid loaded hydrogels: A controlled release study

Ilbey Karakurt et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Add to Collection

Review Chemistry, Multidisciplinary

Oral Fixed-Dose Combination Pharmaceutical Products: Industrial Manufacturing Versus Personalized 3D Printing

Raquel Fernandez-Garcia et al.

PHARMACEUTICAL RESEARCH (2020)

Add to Collection

Article Pharmacology & Pharmacy

Topical buparvaquone nano-enabled hydrogels for cutaneous leishmaniasis

Aikaterini Lalatsa et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Add to Collection

Article Chemistry, Medicinal

Ultradeformable Lipid Vesicles Localize Amphotericin B in the Dermis for the Treatment of Infectious Skin Diseases

Raquel Fernandez-Garcia et al.

ACS INFECTIOUS DISEASES (2020)

Add to Collection

Article Multidisciplinary Sciences

3D bioprinting dual-factor releasing and gradient-structured constructs ready to implant for anisotropic cartilage regeneration

Ye Sun et al.

SCIENCE ADVANCES (2020)

Add to Collection

Article Engineering, Biomedical

Immobilization of BMP-2-derived peptides on 3D-printed porous scaffolds for enhanced osteogenesis

Xiashiyao Zhang et al.

BIOMEDICAL MATERIALS (2020)

Add to Collection

Article Biochemical Research Methods

A modular 3D printed lab-on-a-chip for early cancer detection

Alessandro Chiado et al.

LAB ON A CHIP (2020)

Add to Collection

Article Pharmacology & Pharmacy

'Temporary Plasticiser': A novel solution to fabricate 3D printed patient-centred cardiovascular 'Polypill' architectures

Beatriz C. Pereira et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2019)

Add to Collection

Article Nanoscience & Nanotechnology

Liposomes produced by microfluidics and extrusion: A comparison for scale-up purposes

Vidhi M. Shah et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2019)

Add to Collection

Article Materials Science, Multidisciplinary

High Throughput Nanoliposome Formation Using 3D Printed Microfluidic Flow Focusing Chips

Zhu Chen et al.

ADVANCED MATERIALS TECHNOLOGIES (2019)

Add to Collection

Article Pharmacology & Pharmacy

3D Printed Pellets (Miniprintlets): A Novel, Multi-Drug, Controlled Release Platform Technology

Atheer Awad et al.

PHARMACEUTICS (2019)

Add to Collection

Article Nanoscience & Nanotechnology

Liposome-Encapsulated Curcumin-Loaded 3D Printed Scaffold for Bone Tissue Engineering

Naboneeta Sarkar et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Add to Collection

Article Materials Science, Biomaterials

Development of a 3D-Printed Drug-Eluting Stent for Treating Obstructive Salivary Gland Disease

Tae Ho Kim et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2019)

Add to Collection

Article Pharmacology & Pharmacy

Predicting the critical quality attributes of ibuprofen tablets via modelling of process parameters for roller compaction and tabletting

Antonio Matji et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

Add to Collection

Article Pharmacology & Pharmacy

3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method

Pamela Robles-Martinez et al.

PHARMACEUTICS (2019)

Add to Collection

Article Pharmacology & Pharmacy

Designing Fast-Dissolving Orodispersible Films of Amphotericin B for Oropharyngeal Candidiasis

Dolores R. Serrano et al.

PHARMACEUTICS (2019)

Add to Collection

Article Pharmacology & Pharmacy

Repurposing Butenafine as An Oral Nanomedicine for Visceral Leishmaniasis

Adriana Bezerra-Souza et al.

PHARMACEUTICS (2019)

Add to Collection

Article Pharmacology & Pharmacy

Direct powder extrusion 3D printing: Fabrication of drug products using a novel single-step process

Alvaro Goyanes et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

Add to Collection

Article Pharmacology & Pharmacy

Track-and-trace: Novel anti-counterfeit measures for 3D printed personalized drug products using smart material inks

Sarah J. Trenfield et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

Add to Collection

Article Pharmacology & Pharmacy

Automated therapy preparation of isoleucine formulations using 3D printing for the treatment of MSUD: First single-centre, prospective, crossover study in patients

Alvaro Goyanes et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Formulation and manufacturing of lymphatic targeting liposomes using microfluidics

Swapnil Khadke et al.

JOURNAL OF CONTROLLED RELEASE (2019)

Add to Collection

Article Pharmacology & Pharmacy

Fabrication of Muco-Adhesive Oral Films by the 3D Printing of Hydroxypropyl Methylcellulose-Based Catechin-Loaded Formulations

Tatsuaki Tagami et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2019)

Add to Collection

Article Materials Science, Biomaterials

A 3D printed chitosan-pectin hydrogel wound dressing for lidocaine hydrochloride delivery

Jingjunjiao Long et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

Add to Collection

Article Chemistry, Multidisciplinary

E-Jet 3D-Printed Scaffolds as Sustained Multi-Drug Delivery Vehicles in Breast Cancer Therapy

Xiaoyin Qiao et al.

PHARMACEUTICAL RESEARCH (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Biodegradable magnesium alloys as temporary orthopaedic implants: a review

Sepideh Kamrani et al.

BIOMETALS (2019)

Add to Collection

Article Chemistry, Analytical

A simple procedure to produce FDM-based 3D-printed microfluidic devices with an integrated PMMA optical window

Lucas P. Bressan et al.

ANALYTICAL METHODS (2019)

Add to Collection

Article Engineering, Biomedical

A definition of bioinks and their distinction from biomaterial inks

J. Groll et al.

BIOFABRICATION (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Herringbone-Patterned 3D-Printed Devices as Alternatives to Microfluidics for Reproducible Production of Lipid Polymer Hybrid Nanoparticles

Anuja Bokare et al.

ACS OMEGA (2019)

Add to Collection

Review Pharmacology & Pharmacy

Transforming nanomedicine manufacturing toward Quality by Design and microfluidics

Stefano Colombo et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

Add to Collection

Article Pharmacology & Pharmacy

Optimising the in vitro and in vivo performance of oral cocrystal formulations via spray coating

Dolores R. Serrano et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2018)

Add to Collection

Review Pharmacology & Pharmacy

The importance of microfluidics for the preparation of nanoparticles as advanced drug delivery systems

Joao Pedro Martins et al.

EXPERT OPINION ON DRUG DELIVERY (2018)

Add to Collection

Article Pharmacology & Pharmacy

3D printed microneedles for insulin skin delivery

Cristiane Patricia Pissinato Pere et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

Add to Collection

Article Pharmacology & Pharmacy

3D printing of vaginal rings with personalized shapes for controlled release of progesterone

Junhui Fu et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

Add to Collection

Article Pharmacology & Pharmacy

Production of cocrystals in an excipient matrix by spray drying

David Walsh et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

Add to Collection

Article Medicine, Research & Experimental

Orally Bioavailable and Effective Buparvaquone Lipid-Based Nanomedicines for Visceral Leishmaniasis

Lindsay Smith et al.

MOLECULAR PHARMACEUTICS (2018)

Add to Collection

Article Pharmacology & Pharmacy

Formulation development and process analysis of drug-loaded filaments manufactured via hot-melt extrusion for 3D-printing of medicines

Carolin Korte et al.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2018)

Add to Collection

Review Chemistry, Physical

Drug Delivery Nanosystems for the Localized Treatment of Glioblastoma Multiforme

L. Nam et al.

MATERIALS (2018)

Add to Collection

Review Pharmacology & Pharmacy

Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization

Susan Hua et al.

FRONTIERS IN PHARMACOLOGY (2018)

Add to Collection

Article Materials Science, Multidisciplinary

3D-printed bioabsordable polycaprolactone stent: The effect of process parameters on its physical features

Antonio J. Guerra et al.

MATERIALS & DESIGN (2018)

Add to Collection

Review Dermatology

Three-Dimensional Printing and Cell Therapy for Wound Repair

Sylvia van Kogelenberg et al.

ADVANCES IN WOUND CARE (2018)

Add to Collection

Article Pharmacology & Pharmacy

Engineering of pharmaceutical cocrystals in an excipient matrix: Spray drying versus hot melt extrusion

David Walsh et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

Add to Collection

Review Chemistry, Multidisciplinary

Nanomedicine: Principles, Properties, and Regulatory Issues

Sara Soares et al.

FRONTIERS IN CHEMISTRY (2018)

Add to Collection

Review Polymer Science

Implantable Polymeric Drug Delivery Devices: Classification, Manufacture, Materials, and Clinical Applications

Sarah A. Stewart et al.

POLYMERS (2018)

Add to Collection

Article Chemistry, Analytical

Assessing the Reusability of 3D-Printed Photopolymer Microfluidic Chips for Urine Processing

Eric Lepowsky et al.

MICROMACHINES (2018)

Add to Collection

Review Engineering, Multidisciplinary

A Review of Current Methods in Microfluidic Device Fabrication and Future Commercialization Prospects

Bruce K. Gale et al.

INVENTIONS (2018)

Add to Collection

Article Pharmacology & Pharmacy

Analgesic and anti-inflammatory controlled-released injectable microemulsion: Pseudo-ternary phase diagrams, in vitro, ex vivo and in vivo evaluation

Isabel Pineros et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

Add to Collection

Article Dentistry, Oral Surgery & Medicine

Clinical and Histologic Evaluations of SLA Dental Implants

Myron Nevins et al.

INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY (2017)

Add to Collection

Article Pharmacology & Pharmacy

Patient-specific 3D scanned and 3D printed antimicrobial polycaprolactone wound dressings

Zaid Muwaffak et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

Add to Collection

Article Pharmacology & Pharmacy

Patient acceptability of 3D printed medicines

Alvaro Goyanes et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

Add to Collection

Article Pharmacology & Pharmacy

Unmet clinical needs in the treatment of systemic fungal infections: The role of amphotericin B and drug targeting

Raquel Fernandez-Garcia et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

Add to Collection

Article Pharmacology & Pharmacy

Selective laser sintering (SLS) 3D printing of medicines

Fabrizio Fina et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

Add to Collection

Article Pharmacology & Pharmacy

Oral amphotericin B: The journey from bench to market

Dolores R. Serrano et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2017)

Add to Collection

Article Medicine, Research & Experimental

Engineering Oral and Parenteral Amorphous Amphotericin B Formulations against Experimental Trypanosoma cruzi Infections

Miriam Rolon et al.

MOLECULAR PHARMACEUTICS (2017)

Add to Collection

Article Pharmacology & Pharmacy

Enabling personalized medicine in Europe by the European Commission's funding activities

Elmar Nimmesgern et al.

PERSONALIZED MEDICINE (2017)

Add to Collection

Article Cell & Tissue Engineering

Bioprinting and Organ-on-Chip Applications Towards Personalized Medicine for Bone Diseases

Chiara Arrigoni et al.

STEM CELL REVIEWS AND REPORTS (2017)

Add to Collection

Article Cell & Tissue Engineering

Bioprinting and Organ-on-Chip Applications Towards Personalized Medicine for Bone Diseases

Chiara Arrigoni et al.

STEM CELL REVIEWS AND REPORTS (2017)

Add to Collection

Article Pharmacology & Pharmacy

Cocrystal habit engineering to improve drug dissolution and alter derived powder properties

Dolores R. Serrano et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2016)

Add to Collection

Article Ophthalmology

Developing transcutaneous nanoenabled anaesthetics for eyelid surgery

Aikaterini Lalatsa et al.

BRITISH JOURNAL OF OPHTHALMOLOGY (2016)

Add to Collection

Article Pharmacology & Pharmacy

Modelling and shadowgraph imaging of cocrystal dissolution and assessment of in vitro antimicrobial activity for sulfadimidine/4-aminosalicylic acid cocrystals

Dolores. R. Serrano et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2016)

Add to Collection

Article Pharmacology & Pharmacy

Stereolithographic (SLA) 3D printing of oral modified-release dosage forms

Jie Wang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)

Add to Collection

Review Pharmacology & Pharmacy

Microfluidics: a transformational tool for nanomedicine development and production

Shyam Garg et al.

JOURNAL OF DRUG TARGETING (2016)

Add to Collection

Article Chemistry, Multidisciplinary

Lomustine Nanoparticles Enable Both Bone Marrow Sparing and High Brain Drug Levels - A Strategy for Brain Cancer Treatments

Funmilola A. Fisusi et al.

PHARMACEUTICAL RESEARCH (2016)

Add to Collection

Article Engineering, Biomedical

3D-printed microfluidic chips with patterned, cell-laden hydrogel constructs

Stephanie Knowlton et al.

BIOFABRICATION (2016)

Add to Collection

Review Chemistry, Medicinal

Emerging Nanonisation Technologies: Tailoring Crystalline Versus Amorphous Nanomaterials

Dolores R. Serrano et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2015)

Add to Collection

Article Pharmacology & Pharmacy

A controlled antibiotic release system to prevent orthopedic-implant associated infections: An in vitro study

Marina Gimeno et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2015)

Add to Collection

Article Pharmacology & Pharmacy

3D printing of tablets containing multiple drugs with defined release profiles

Shaban A. Khaled et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)

Add to Collection

Article Chemistry, Multidisciplinary

Chitosan amphiphile coating of peptide nanofibres reduces liver uptake and delivers the peptide to the brain on intravenous administration

A. Lalatsa et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Add to Collection

Article Chemistry, Multidisciplinary

3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles

Shaban A. Khaled et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Add to Collection

Article Engineering, Biomedical

Iron and iron-based alloys for temporary cardiovascular applications

A. Francis et al.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2015)

Add to Collection

Article Chemistry, Medicinal

Polymorphism in Sulfadimidine/4-Aminosalicylic Acid Cocrystals: Solid-State Characterization and Physicochemical Properties

Christine Grossjohann et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2015)

Add to Collection

Article Medicine, Research & Experimental

3D Printing of Medicines: Engineering Novel Oral Devices with Unique Design and Drug Release Characteristics

Alvaro Goyanes et al.

MOLECULAR PHARMACEUTICS (2015)

Add to Collection

Article Medicine, Research & Experimental

Oral Particle Uptake and Organ Targeting Drives the Activity of Amphotericin B Nanoparticles

Dolores R. Serrano et al.

MOLECULAR PHARMACEUTICS (2015)

Add to Collection

Editorial Material Biotechnology & Applied Microbiology

Cost-effectiveness of nanomedicine: the path to a future successful and dominant market?

Rita Bosetti

NANOMEDICINE (2015)

Add to Collection

Review Pharmacology & Pharmacy

Nanomedicine Scale-up Technologies: Feasibilities and Challenges

Rishi Paliwal et al.

AAPS PHARMSCITECH (2014)

Add to Collection

Article Pharmacology & Pharmacy

New amphotericin B-gamma cyclodextrin formulation for topical use with synergistic activity against diverse fungal species and Leishmania spp.

Helga K. Ruiz et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2014)

Add to Collection

Review Chemistry, Multidisciplinary

25th Anniversary Article: Engineering Hydrogels for Biofabrication

Jos Malda et al.

ADVANCED MATERIALS (2013)

Add to Collection

Article Pharmacology & Pharmacy

Hemolytic and pharmacokinetic studies of liposomal and particulate amphotericin B formulations

Dolores R. Serrano et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

Add to Collection

Review Pharmacology & Pharmacy

Peptide pills for brain diseases? Reality and future perspectives

Dolores Remedios Serrano Lopez et al.

THERAPEUTIC DELIVERY (2013)

Add to Collection

Article Pharmacology & Pharmacy

Novel Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) for Oral Delivery of Cinnarizine: Design, Optimization, and In-Vitro Assessment

Ahmad Abdul-Wahhab Shahba et al.

AAPS PHARMSCITECH (2012)

Add to Collection

Article Pharmacology & Pharmacy

A novel formulation of solubilised amphotericin B designed for ophthalmic use

D. R. Serrano et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2012)

Add to Collection

Review Materials Science, Multidisciplinary

Nickel-free austenitic stainless steels for medical applications

Ke Yang et al.

SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS (2010)

Add to Collection

Review Dentistry, Oral Surgery & Medicine

In vitro and in vivo studies on the toxicity of dental resin components: a review

Michel Goldberg

CLINICAL ORAL INVESTIGATIONS (2008)

Add to Collection

Article Developmental Biology

The resin monomer triethylene glycol dimethacrylate exhibits reproductive toxicity in male mice

H Darmani et al.

REPRODUCTION FERTILITY AND DEVELOPMENT (2005)

Add to Collection

Article Chemistry, Medicinal

Project, design, and use of a pilot plant for nanocapsule production

AP Colombo et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2001)

Add to Collection

© Peeref 2019-2024. All rights reserved.