Journal
CELL HOST & MICROBE
Volume 18, Issue 2, Pages 133-134Publisher
CELL PRESS
DOI: 10.1016/j.chom.2015.07.009
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Dengue virus RNA is trimmed by the 50/30 exoribonuclease XRN1 to produce an abundant, non-coding sub-genomic flavivirus RNA (sfRNA) in infected cells. In a recent paper in Science, Manokaran et al. (2015) report that sfRNA binds TRIM25 to evade innate immune sensing of viral RNA by RIG-I.
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