Nanoemulgel: A Novel Nano Carrier as a Tool for Topical Drug Delivery

Nano-emulgel is an emerging drug delivery system intended to enhance the therapeutic profile of lipophilic drugs. Lipophilic formulations have a variety of limitations, which includes poor solubility, unpredictable absorption, and low oral bioavailability. Nano-emulgel, an amalgamated preparation of different systems aims to deal with these limitations. The novel system prepared by the incorporation of nano-emulsion into gel improves stability and enables drug delivery for both immediate and controlled release. The focus on nano-emulgel has also increased due to its ability to achieve targeted delivery, ease of application, absence of gastrointestinal degradation or the first pass metabolism, and safety profile. This review focuses on the formulation components of nano-emulgel for topical drug delivery, pharmacokinetics and safety profiles.

Automated summary

Nano-emulgel is a novel drug delivery system that aims to enhance the therapeutic effectiveness of lipophilic drugs. It addresses the limitations of lipophilic formulations such as poor solubility, unpredictable absorption, and low oral bioavailability. By incorporating nano-emulsion into gel, the stability and drug delivery for immediate and controlled release are improved. The focus on nano-emulgel has increased due to its targeted delivery, ease of application, absence of gastrointestinal degradation or the first pass metabolism, and safety profile. This review discusses the formulation components, pharmacokinetics, and safety profiles of nano-emulgel for topical drug delivery.