Immunoregulatory framework and the role of miRNA in the pathogenesis of NSCLC - A systematic review

With a 5-year survival rate of only 15%, non-small cell lung cancer (NSCLC), the most common kind of lung carcinoma and the cause of millions of deaths annually, has drawn attention. Numerous variables, such as disrupted signaling caused by somatic mutations in the EGFR-mediated RAS/RAF/MAPK, PI3K/AKT, JAK/STAT signaling cascade, supports tumour survival in one way or another. Here, the tumour microenvironment significantly contributes to the development of cancer by thwarting the immune response. MicroRNAs (miRNAs) are critical regulators of gene expression that can function as oncogenes or oncosuppressors. They have a major influence on the occurrence and prognosis of NSCLC. Though, a myriad number of therapies are available and many are being clinically tested, still the drug resistance, its adverse effect and toxicity leading towards fatality cannot be ruled out. In this review, we tried to ascertain the missing links in between perturbed EGFR signaling, miRNAs favouring tumorigenesis and the autophagy mechanism. While connecting all the aforementioned points multiple associations were set, which can be targeted in order to combat NSCLC. Here, we tried illuminating designing synthetically engineered circuits with the toggle switches that might lay a prototype for better therapeutic paradigm.

Automated summary

With a low 5-year survival rate and millions of deaths annually, non-small cell lung cancer (NSCLC) has become a major concern. The disrupted signaling caused by somatic mutations and the tumor microenvironment play significant roles in the development of NSCLC. MicroRNAs (miRNAs) have a major influence on the occurrence and prognosis of NSCLC. Despite the availability of numerous therapies, drug resistance and adverse effects remain challenges. Understanding the connections between perturbed EGFR signaling, miRNAs, and autophagy mechanism may provide new therapeutic approaches for NSCLC.